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Integrating Artificial Intelligence for Drug Discovery in the Context of Revolutionizing Drug Delivery
Drug development is expensive, time-consuming, and has a high failure rate. In recent years, artificial intelligence (AI) has emerged as a transformative tool in drug discovery, offering innovative solutions to complex challenges in the pharmaceutical industry. This manuscript covers the…
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An Overview of Corporate Sustainability Reporting Legislation in the European Union
In recent years, sustainability disclosure has increasingly become mandatory in many countries. The European Union (EU) is at the forefront of this change by adopting legislation that governs disclosure of (i) companies’ sustainability aspects (Corporate Sustainability Reporting Directive), (ii)…
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Benign separation, adsorption, and recovery of rare-earth Yb(III) ions with specific ligand-based composite adsorbent
This study developed a ligand-based composite adsorbent (ComA) for efficient Ytterbium (Yb(III)) adsorption and recovery from waste samples. The organic ligand of 1E,1`E,1``E,1```E (tetrakis(3-carboxysalicylidene)) naphthalene-1,2,5,5-tetramine (TSNT) was synthesized and TSTN was successfully…
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Predicting the Performance and Adaptation of Artificial Elbow Due to Effective Forces using Deep Learning
Measuring power transmission in organs poses a significant challenge for researchers in the field, with various methods being explored, including the use of artificial intelligence algorithms. This study focused on developing a new neural network model to predict force transmission and performance…
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Differences across the lifespan between females and males in the top 20 causes of disease burden globally: a systematic analysis of the Global Burden of Disease Study 2021
BACKGROUND: Sex and gender shape health. There is a growing body of evidence focused on comprehensively and systematically examining the magnitude, persistence, and nature of differences in health between females and males. Here, we aimed to quantify differences in the leading causes of disease…
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Microplastics in human blood: Polymer types, concentrations and characterisation using μFTIR
Microplastics (MPs) are an everyday part of life, and are now ubiquitous in the environment. Crucially, MPs have not just been found within the environment, but also within human bodies, including the blood. We aimed to provide novel information on the range of MP polymer types present, as well as…
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The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer
Aberrant activation of the PI3K/Akt pathway commonly occurs in cancers and correlates with multiple aspects of malignant progression. In particular, recent evidence suggests that the PI3K/Akt signaling plays a fundamental role in promoting the so-called aerobic glycolysis or Warburg effect, by…
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Determinación De Erodabilidad En Áreas De Influencia Cuenca Poopo Región Andina De Bolivia
El presente trabajo de investigación nace como un objetivo desarrollar a partir de los principios metodológicos para la recuperación de suelos con problemas de erosión hídrica y eólica a partir de la aplicación de las condiciones climáticas adversas para determinar el comportamiento de las…
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Prospective study design and data analysis in UK Biobank
Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improve…
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Tissue accumulation of microplastics and potential health risks in human
Microplastics have become ubiquitous throughout the environment. Humans constantly ingest and inhale microplastics, increasing concerns about the health risks of microplastic exposure. However, limited data impedes a full understanding of the internal exposure to microplastics. Herein, to evaluate…
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Nanomedicine Tumor Targeting
Nanomedicines are extensively explored for cancer therapy. By delivering drug molecules more efficiently to pathological sites and by attenuating their accumulation in healthy organs and tissues, nanomedicine formulations aim to improve the balance between drug efficacy and toxicity. More than 20…
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Challenges and barriers of using large language models (LLM) such as ChatGPT for diagnostic medicine with a focus on digital pathology – a recent scoping review
BACKGROUND: The integration of large language models (LLMs) like ChatGPT in diagnostic medicine, with a focus on digital pathology, has garnered significant attention. However, understanding the challenges and barriers associated with the use of LLMs in this context is crucial for their successful…
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Clinical applications of artificial intelligence in robotic surgery
Artificial intelligence (AI) is revolutionizing nearly every aspect of modern life. In the medical field, robotic surgery is the sector with some of the most innovative and impactful advancements. In this narrative review, we outline recent contributions of AI to the field of robotic surgery with a…
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Artificial Intelligence and Machine Learning Techniques for Anomaly Detection and Threat Mitigation in Cloud-Connected Medical Devices
The Internet of Medical Things (IoMT) has begun functioning like this: improved patient monitoring and an easily accessible digital data warehouse. Despite that, this methodology of the internet will potentially have a counter balance which risks for patient data might involve hacking, data theft…
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REVOLUTIONIZING EDUCATION THROUGH AI: A COMPREHENSIVE REVIEW OF ENHANCING LEARNING EXPERIENCES
Artificial Intelligence (AI) is transforming the landscape of education, offering innovative solutions to enhance learning experiences. This review provides a comprehensive overview of how AI is revolutionizing education, focusing on its impact on learning outcomes, teaching methodologies, and the…
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Blockchain-Enabled Security Solutions for Medical Device Integrity and Provenance in Cloud Environments
The current period of medicine using digital technology for patient care presents a new level of integration of monitoring devices with the cloud computing environment that enables the collection, storage and access to data in ways that were never possible earlier. As the obvious part of this…
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Prevalence of cancer survivors in the United States
BACKGROUND: With aging of the population and improvements in diagnosis, treatment, and supportive care, the number of cancer survivors in the United States has increased; updated prevalence estimates are needed. METHODS: Cancer prevalence on January 1, 2022, was estimated using the Prevalence…
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Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study
BACKGROUND: Coronary computed tomography angiography (CCTA) is the first line investigation for chest pain, and it is used to guide revascularisation. However, the widespread adoption of CCTA has revealed a large group of individuals without obstructive coronary artery disease (CAD), with unclear…
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