417,678 results
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Characterization of monotone Boolean models supporting fixed points and multistability in balanced networks
Gene regulatory networks (GRN) control the expression levels of proteins in cells, and understanding their dynamics is key to potentially controlling disease processes. Steady states of GRNs are interpreted as cellular phenotypes, and the first step in understanding GRN dynamics is describing the…
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Targeted sequencing enhances detection of pangolin trafficking hotspots and dynamics of both domestic and global trade markets
Pangolins have become emblematic of the global wildlife trade crisis due to intense trafficking for consumption and traditional medicine. Coupled with habitat loss, the illicit trade in pangolins has severely threatened wild populations. Genetic identification of distinct pangolin populations is an…
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Tracing the pathways to Yathrib (Al-Madinah): A GIS-based analysis of settlement patterns and ancient trade networks
Ancient human activities in the arid Arabia peninsula are considered one of interesting research subjects in the landscape archaeological field to understand the relationships between human occupation strategies, material culture, and the natural environment in the past. Focusing on Al-Madinah…
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Identification and functional analysis of key miRNAs and target genes associated with failure of HBV mother-to-child transmission prevention
Background: Residual mother-to-child transmission (MTCT) of hepatitis B virus (HBV) remains a significant clinical challenge despite standard immunoprophylaxis. Identifying molecular markers is crucial for improved prevention and diagnosis. Methods: We conducted a case-control study using the…
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Serum cholinesterase as a biomarker for sepsis-associated immunosuppression via Hub gene RORA
Background: Sepsis-induced immunosuppression is a key factor contributing to high mortality rates. However, suitable biomarkers for routine clinical monitoring of immune function are currently lacking. Serum cholinesterase levels are markedly diminished in sepsis and are associated with unfavorable…
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Structured water molecules drive activation and G protein selectivity in the GPR174 receptor
G protein-coupled receptor 174 (GPR174), a key modulator of autoimmune responses, maintains immune homeostasis through distinct G protein signaling pathways, particularly Gs and Gi. Although the structural mechanism of lysophosphatidylserine (LysoPS)-activated GPR174 in the Gs pathway has been…
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Ten simple rules for establishing a drug discovery lab in resource-limited settings
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Methicillin-resistant Staphylococcus aureus along the beef production line: Phenotypic resistance and mecA phylogeny in two ethiopian municipal abattoirs
Staphylococcus aureus (S. aureus) is a common zoonotic bacteria, responsible for a wide range of infections and is well known for developing resistance to multiple antibiotics. In Ethiopia, information on methicillin-resistant S. aureus (MRSA), particularly from a One-Health perspective, is…
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Research on multi-sensor fusion architecture for highway area hazard monitoring based on UAVs
Highway area geohazards pose a serious threat to traffic safety, and traditional monitoring echniques struggle to meet the requirements for high precision and real-time capability, while existing unmanned aerial vehicles (UAVs) multi-sensor fusion schemes lack adaptability across diverse areas…
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Injury incidence, patterns, and severity in cameroon professional Men’s Football: A prospective injury surveillance study
Background: Football injuries are a major source of morbidity among athletes, imposing health and economic burdens on teams and systems. While extensive surveillance exists in Europe, data from sub-Saharan Africa remain scarce. This study described the incidence, patterns, severity, and contextual…
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Evaluation of non-invasive hemoglobin measurement in blood donors at a tertiary care hospital, Bangkok, Thailand
Background: Hemoglobin (Hb) assessment is crucial to prevent blood donation from anemic donors. Most measurements are invasive and painful; however, an alternative, non-invasive hemoglobin measurement is available. This study aimed to compare non-invasive and point-of-care invasive hemoglobin test…
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The mediating role of insomnia symptoms in the association between perceived neighborhood danger and depressive symptoms in later life
Perceived neighborhood danger poses significant risks to mental health in later life, yet the underlying psychological mechanisms remain unclear. Given that environmental stressors can compromise sleep health, we conceptualize insomnia symptoms as a potential mediator in the association between…
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Factors associated with high viral load among HIV clients aged 15 years and older receiving treatment in Tanga city council, Tanzania: A facility-based cross-sectional study
Background: High viral load indicates poor treatment outcomes among people living with HIV (PLHIV) on antiretroviral therapy (ART). However, there is a dearth of evidence on specific factors associated with high viral load in resource-limited settings, including Tanzania. Aim: The aim of this study…
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Large language models are poor clinical administrators: An evaluation of structured queries in real-world electronic health records
Large language models (LLMs) have shown promise in interpreting clinical free-text like provider notes. There is limited evidence on tabular electronic health record (EHR) tasks. Our objective was to evaluate the accuracy of LLMs on structured EHR administrative tasks using direct prompting…
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Environmental uncertainty shapes human effort learning
Humans show remarkable flexibility in adapting their behaviour to constantly changing environments. This flexibility relies on the ability to regulate motivation in response to changing motivational demands. Typically, the amount of effort required to achieve a certain goal is not precisely…
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Artificial intelligence algorithm for real-time detection and counting of Trypanosoma cruzi parasites using smartphone microscopy
Chagas disease affects 6–7 million people worldwide and causes approximately 12,000 deaths annually. Diagnostic methods vary by disease stage, with serological tests commonly used in the chronic phase, while microscopy and molecular techniques like PCR and LAMP are employed in the acute phase…
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Weak selection and stochastic processes limit the emergence of antigenic variants during household transmission of influenza A viruses
Influenza viruses undergo antigenic drift, the gradual accumulation of mutations that cause antigenic changes in the viral surface proteins hemagglutinin (HA) and neuraminidase (NA). Although selection for antigenic variants is detectable on the global scale, the processes by which antigenic…
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An IL-1, IL-17, and IL-22 cytokine circuit controls vulvovaginal candidiasis independently of estrogen
Vulvovaginal candidiasis (VVC) affects >75% of women, with considerable morbidity and high medical cost burden. While Type 17 cytokines (IL-17, IL-22) are critical for oral and dermal immunity to C. albicans, their role in VVC has been less clear. Th17 gene signatures are potently upregulated in…
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