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Journal Article
Regulatory pathways and guidelines for nanotechnology-enabled health products: a comparative review of EU and US frameworks
The integration of nanotechnology into healthcare has introduced Nanotechnology-Enabled Health Products (NHPs), promising revolutionary advancements in medical treatments and diagnostics. Despite their potential, the regulatory navigation for these products remains complex and often lagging…
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Journal Article
Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer
BACKGROUND: The best multimodal approach for resectable locally advanced esophageal adenocarcinoma is unclear. An important question is whether perioperative chemotherapy is preferable to preoperative chemoradiotherapy. METHODS: In this phase 3, multicenter, randomized trial, we assigned in a 1:1…
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Journal Article Full text
Antibody–Drug Conjugates (ADCs): current and future biopharmaceuticals
Antibody-drug conjugates (ADCs) represent a novel class of biopharmaceuticals comprising monoclonal antibodies covalently conjugated to cytotoxic agents via engineered chemical linkers. This combination enables targeted delivery of cytotoxic agents to tumor site through recognizing target antigens…
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Journal Article
High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancer
A comprehensive understanding of cellular behavior and response to the tumor microenvironment (TME) in colorectal cancer (CRC) remains elusive. Here, we introduce the high-definition Visium spatial transcriptomic technology (Visium HD) and investigate formalin-fixed paraffin-embedded human CRC…
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The global human impact on biodiversity
Abstract Human activities drive a wide range of environmental pressures, including habitat change, pollution and climate change, resulting in unprecedented effects on biodiversity 1,2 . However, despite decades of research, generalizations on the dimensions and extent of human impacts on…
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Journal Article
Global, regional, and national burden of epilepsy, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
BACKGROUND: Epilepsy is one of the most common serious neurological disorders and affects individuals of all ages across the globe. The aim of this study is to provide estimates of the epilepsy burden on the global, regional, and national levels for 1990-2021. METHODS: Using well established Global…
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Journal Article Full text
Artificial intelligence in healthcare and medicine: clinical applications, therapeutic advances, and future perspectives
Healthcare systems worldwide face growing challenges, including rising costs, workforce shortages, and disparities in access and quality, particularly in low- and middle-income countries. Artificial intelligence (AI) has emerged as a transformative tool capable of addressing these issues by…
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Book
De jure belli ac pacis libri tres
ist Professor für Deutsche Rechtsgeschichte, Neuere Privatrechtsgeschichte und Bürgerliches Recht an der Universität Hamburg.
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Journal Article Full text
Critically assessing sodium-ion technology roadmaps and scenarios for techno-economic competitiveness against lithium-ion batteries
Sodium-ion batteries are considered a promising substitute for Li-ion, but the timeline and conditions for achieving cost-competitiveness remain uncertain. This study evaluates their techno-economic potential, showing that while challenging, they could compete with low-cost Li-ion batteries by the…
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Journal Article
Advancing energy storage: The future trajectory of lithium-ion battery technologies
Lithium-ion batteries are pivotal in modern energy storage, driving advancements in consumer electronics, electric vehicles (EVs), and grid energy storage. This review explores the current state, challenges, and future trajectory of lithium-ion battery technology, emphasizing its role in addressing…
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Journal Article
The Faiss Library
Vector databases typically manage large collections of embedding vectors. As AI applications are growing rapidly, the number of embeddings that need to be stored and indexed is increasing. The Faiss library is dedicated to vector similarity search, a core functionality of vector databases. Faiss is…
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Journal Article Full text
Pesticides have negative effects on non-target organisms
Pesticides affect a diverse range of non-target species and may be linked to global biodiversity loss. The magnitude of this hazard remains only partially understood. We present a synthesis of pesticide (insecticide, herbicide and fungicide) impacts on multiple non-target organisms across trophic…
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Journal Article Full text
SPIRIT 2025 statement: updated guideline for protocols of randomised trials
IMPORTANCE: The protocol of a randomised trial is the foundation for study planning, conduct, reporting, and external review. However, trial protocols vary in their completeness and often do not address key elements of design and conduct. The SPIRIT (Standard Protocol Items: Recommendations for…
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Journal Article Full text
CONSORT 2025 statement: updated guideline for reporting randomised trials
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Silver Nanoparticles (AgNPs): Comprehensive Insights into Bio/Synthesis, Key Influencing Factors, Multifaceted Applications, and Toxicity─A 2024 Update
Silver nanoparticles (AgNPs) are widely recognized for their unique optical, electronic, and antibacterial properties, enabling their use in biosensing, photonics, electronics, drug delivery, and antimicrobial treatments. Green chemistry-based biological synthesis methods offer an eco-friendly…
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Journal Article
Medical SAM adapter: Adapting segment anything model for medical image segmentation
The Segment Anything Model (SAM) has recently gained popularity in the field of image segmentation due to its impressive capabilities in various segmentation tasks and its prompt-based interface. However, recent studies and individual experiments have shown that SAM underperforms in medical image…
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