9 results for "Boxuan Han"
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Journal Article
Gut microbiome’s causal role in head and neck cancer: findings from mendelian randomization
IntroductionThe gut microbiome (GM) has been implicated in cancer pathogenesis and treatment, including head and neck cancers (HNC). However, the specific microbial compositions influencing HNC and the underlying mechanisms remain largely unknown.MethodsThis study utilized published genome-wide…
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Journal Article
The association between diabetes and head and neck squamous cell carcinoma: evidence from clinical cohort and bioinformatics analyses
IntroductionDiabetes mellitus (DM) is a known risk factor for various cancers, but its relationship with head and neck squamous cell carcinoma (HNSCC) remains unclear. This study explores clinical and molecular links between DM and HNSCC through integrative analyses of patient data and…
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Journal Article Full text
Humor Production Promotes Creativity: The Mediating Role of Self-Efficacy and the Moderating Role of Fear of Authority
We conducted four empirical studies to investigate how, why, and when humor production impacts people’s creativity. Study 1 (N = 175), using the cartoon humor production paradigm, found that humor production was positively associated with creativity. Study 2 (N = 243), using a new sample, found…
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Journal Article Full text
Antiaging Effect of 2-O-β-D-Glucopyranosyl Ascorbic Acid Derived from Lycium barbarum L. Through Modulating the IIS Pathway and Gut Microbiota in Caenorhabditis elegans
2-O-β-D-Glucopyranosyl ascorbic acid (AA-2βG), a bioactive ascorbic acid derivative isolated from the fruits of Lycium barbarum L., exhibited significant antiaging effects in Caenorhabditis elegans. It significantly extended their lifespan, enhanced stress resistance, reduced lipofuscin…
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Journal Article
PPARG and the PTEN-PI3K/AKT Signaling Axis May Cofunction in Promoting Chemosensitivity in Hypopharyngeal Squamous Cell Carcinoma
It has been demonstrated that PPARG may interact with the PTEN-PI3K/AKT pathway, contributing to its involvement in the chemotherapy treatment of hypopharyngeal squamous cell carcinoma (HSCC). However, the underlying mechanism remains largely unknown. In this study, gene expression profiles of 17…
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Journal Article
Role of PPARG in Chemosensitivity-Regulating Network for Hypopharyngeal Squamous Cell Carcinoma
PPARG has been reported to promote chemosensitivity in hypopharyngeal squamous cell carcinoma (HSCC). However, few studies tested its significance in the texture of a complex molecular network regulating chemosensitivity in HSCC. Here, we first employed RNA expression data analysis and literature…
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Journal Article
Explore the possible influence of Sjogren's syndrome on thyroid cancer: A literature data mining and meta-analysis.
ObjectivesTo explore the potential influence of Sjogren's syndrome (SS) on thyroid cancer (TC).MethodsFirst, a literature data mining (LDM) approach was used to reconstruct functional pathways connecting SS and TC. A meta-analysis was then performed to examine the expression changes of genes…
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Journal Article
Genetic predisposition to milder forms of COVID-19 may provide some resilience to head and neck cancers
IntroductionThe impact of the COVID-19 pandemic on head and neck cancer (HNC) has been suggested, but the causal relationship remains unclear.MethodsWe explore this connection by utilizing the Mendelian randomization (MR) approach applied to publicly available genome-wide association study (GWAS)…
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Journal Article
Investigating the impact of clinical and genetic factors on the post-surgery prognosis of sinonasal squamous cell carcinoma
Abstract Sinonasal squamous cell carcinoma (SNSCC) is an aggressive cancer affecting the nasal and sinus regions, with its progression factors, particularly genetic ones, not yet fully understood. Here, we first conducted a retrospective study with 219 SNSCC patients to identify clinical factors…