8 results for "Mahboubeh Irani"
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Journal Article
Inhibition of Heme Polymerization, the Mechanism of Antimalarial Activity in Phlomis caucasica Rech.f. (Lamiaceae)
Background: Malaria is one of the most important parasitic diseases in the world caused by Plasmodium species. The malaria parasite digests hemoglobin in vacuole to amino acids and heme. Plasmodium has got several detoxification mechanisms to protect itself from toxic heme. The most important…
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Journal Article
Synthesis of novel amodiaquine analogs and evaluation of their in vitro and in vivo antimalarial activities
Background & objectives: Due to the rapid increase of drug resistance in Plasmodium parasites, there is a pressing need of developing new antiplasmodial drugs. In this study, new amodiaquine (AQ) analogs were synthesized, followed by an evaluation of their antiplasmodial activity. Methods: A new…
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Journal Article Full text
Gaillardin Induces Apoptosis in HepG2 Hepatocellular Carcinoma Cells via Caspase Activation
Background and objectives: Hepatocellular carcinoma is the most common liver cancer in the world. Lifestyle, hepatitis viruses and liver diseases are among the most probable risk factors for hepatocellular carcinoma. Natural products have recently been the focus of liver cancer investigations…
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Gaillardin Impedes Human Ovarian Cancer Metastasis by Acting on Epithelial-Mesenchymal Transition and Angiogenic Factors
Background and objectives: Ovarian cancer is the seventh most frequent cancer and the fifth most common cause of death in women in the world. Gaillardin is a sesquiterpene lactone with anti-cancer effects on different cancer cell lines. This study was conducted to explore the cytotoxic effect of…
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Journal Article Full text
Britannin suppresses MCF-7 breast cancer cell growth by inducing apoptosis and inhibiting autophagy
Objective: Breast cancer is the main reason for cancer-related death in women. Britannin is a sesquiterpene lactone compound derived from Inula aucheriana with anti-tumor properties. We aimed to explore the impacts of britannin on apoptosis and autophagy in MCF-7 breast cancer cell line.Materials…
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Identification of Potent Cytotoxic Plants from Ilam: An In Vitro Approach
Background and objectives: Despite the innovative technologies and the common treatments, cancer remains a significant problem. Since medicinal plants play a crucial role in guiding the development of new pharmaceuticals, this study aimed to assess the cytotoxic effects of selected plants from Ilam…
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Journal Article
Effect of gaillardin on the metastatic capacity of breast cancer cells and its underlying mechanism
The metastasis process plays an important role in the outcome of all cancers, including breast cancer, a leading cause of cancer mortality in women. This study assessed the effects of gaillardin on the metastatic activity of two different breast cancer cell lines. The MTT assay was used to obtain…
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Journal Article
Harnessing the power of gaillardin: A natural sesquiterpene with anti-ovarian Cancer potential
Ovarian cancer is the eighth most frequent cancer and fifth most common cause of death in women in the world. Gaillardin is a sesquiterpene lactone with an anti-tumor effect on different cancers. This study explored the anti-proliferative and pro-apoptotic effect of gaillardin on the ovarian cancer…