131 hasil untuk "Daniel Simancas-Racines"
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Artikel Jurnal
Metodología en la optimización de bases de datos de los sistemas de información en salud de Ecuador para el monitoreo en tiempo real de eventos críticos para la vigilancia epidemiológica. Reporte de implementación
Contar con datos oportunos, eficientes, y sistemas de información resilientes en el ámbito de la salud es fundamental para el monitoreo en tiempo real de eventos críticos que impactan la vigilancia epidemiológica y la salud pública. Este artículo se enfoca en mostrar una metodología para la…
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Regional, altitudinal, and age-specific heterogeneity of bronchiolitis hospitalization seasonality in Ecuador, 2007–2024, and implications for RSV immunoprophylaxis timing
BackgroundAcute bronchiolitis, mainly attributed to respiratory syncytial virus (RSV), is the leading cause of infant hospitalization for lower respiratory tract disease worldwide. Nirsevimab and maternal RSVpreF (Abrysvo) confer about 6 months of protection, so timing relative to the season…
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Nutrition and longevity – diet in centenarians
Abstract Background Nutrition plays a central role in the biological mechanisms that shape aging, health span, and longevity. Micronutrients—including vitamins, trace elements, and polyphenols—support genomic stability, mitochondrial integrity, and antioxidant defense, while dietary patterns rich…
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Association between type of health insurance and dental visits among Ecuadorian older population: evidence from a cross-sectional study
Abstract Background Dental services are often overlooked within healthcare systems, despite their critical role in overall health. Socioeconomic barriers and disparities in insurance coverage frequently limit access to oral care, particularly among vulnerable populations like older adults…
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Actual macronutrient composition of the Mediterranean diet and its association with adiposity and inflammation: a cross-sectional real-life study
Abstract Background and objectives The Mediterranean diet (MD) relies on a specific food consumption pattern that has been given pleiotropic effects on human health. However, even foods typically considered beneficial within the MD framework may vary in macronutrient composition, potentially…
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Melanoma maligno: frecuencia y distribución en un hospital de referencia de la seguridad social
Objetivo: Describir la frecuencia, magnitud y tratamiento de los diversos tipos de melanoma diagnosticados en el Hospital de Especialidades Carlos Andrade Marín (HECAM) de la ciudad de Quito. Métodos: Se realizó un estudio transversal de los pacientes que acudieron a la clínica de Melanoma del…
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Artikel Jurnal
Apoyo político y microplanificación como factores de éxito para una campaña de vacunación de seguimiento de alta calidad, Ecuador, 2023
Objetivo. Describir los resultados y logros en la cobertura administrativa y monitoreo rápido de vacunación (MRV) de la campaña de vacunación de seguimiento (CVS) y las lecciones aprendidas, en el contexto de la prioridad política y la microplanificación como factores determinantes en las…
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Heavy metals in the diet: unraveling the molecular pathways linked to neurodegenerative disease risk
Neurodegenerative diseases (NDDs) affect millions of lives worldwide. They constitute a group of neurological disorders with shared common features, including impaired cognition, behavior, memory, and motor functions. These conditions arise due to the gradual degeneration of neurons within the…
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Next-Generation sequencing in a Native American patient with sea-blue histiocytosis: A case report and genomic analysis
This study presents a case of a 25-year-old Native American woman from Otavalo, Ecuador, diagnosed with sea-blue histiocytosis and myelodysplastic syndrome. Bone marrow aspiration revealed sea-blue histiocytes, and next-generation sequencing identified a likely pathogenic stop-gain mutation in the…
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Artikel Jurnal
Characterization of a variant in the KCNH2 gene in an Ecuadorian patient with long QT syndrome: A case report
Long QT syndrome is a rare cardiac channelopathy characterized by prolonged QT intervals and altered T wave morphology. The etiology of long QT syndrome is multifactorial, including environmental and genetic factors. In addition, several heart diseases have been associated with the individual's…
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Very low-calorie ketogenic diet (VLCKD): a therapeutic nutritional tool for acne?
Abstract Background Acne, a chronic inflammatory disease impacting the pilosebaceous unit, is influenced significantly by inflammation and oxidative stress, and is commonly associated with obesity. Similarly, obesity is also associated with increased inflammation and oxidation. The role of diet in…
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Genomic analysis of an Ecuadorian individual carrying an SCN5A rare variant
Abstract Background Ion channels, vital transmembrane protein complexes, regulate ion movement within cells. Germline variants in channel-encoding genes lead to channelopathies. The sodium channels in cardiac cells exhibit a structure of an alpha subunit and one to two beta subunits. The alpha…
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Neurofibromatosis Type 1 in Ecuador: genotype-phenotype correlations from a case series
Introduction Neurofibromatosis type 1 (NF1) is a multisystemic genetic disorder caused by pathogenic variants in the gene, characterized by variable clinical manifestations such as pigmentary abnormalities, neurofibromas, skeletal dysplasia, and tumor predisposition. However, genotype–phenotype…
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Information and communication technology use in asthmatic patients: a cross-sectional study in Latin America
Rapid diffusion, low cost and broad availability of information and communication technologies (ICTs) make them an attractive platform for managing care, communication and interventions in asthma. There is little information in Latin America about usage frequency of ICTs in asthmatic patients. The…
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Self-Reported Prevalence of Chronic Non-Communicable Diseases Concerning Socioeconomic and Educational Factors: Analysis of the PURE-Ecuador Cohort
Background: The changing epidemiological landscape, marked by the increasing prominence of Non-Communicable Chronic Diseases (NCDs), underscores the need for studies that identify and analyze these conditions and their associated risk factors. This secondary analysis aims to describe the…
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Perception, knowledge and attitudes of Ecuadorian dentists towards patients with molar incisor hypomineralization
BackgroundMolar Incisor Hypomineralization (MIH) is one of the most prevalent enamel development defects in contemporary dental practice. Understanding perceptions, knowledge, and attitudes of professionals towards this condition is key to optimizing clinical protocols and improving therapeutic…
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Beyond dietary therapy: addressing weight stigma awareness in medical students
Abstract Background The growing prevalence of obesity worldwide has drawn increased attention to the issue of weight stigma. Discriminatory attitudes related to body weight are evident across various settings, including those that should ideally offer support to individuals with obesity, such as…
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The role of the Mediterranean diet in prediabetes management and prevention: a review of molecular mechanisms and clinical outcomes
The Mediterranean diet (MedDiet), originating from areas around the Mediterranean Sea, emphasises olive oil, fruits, vegetables, legumes, whole grains, and nuts while limiting red and processed meats. Studies show that higher adherence to the MedDiet reduces mortality risk by 23%. This diet…
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A potentially fruitful path toward a cleaner and safer environment: MXenes uses in environmental remediation
The rapid industrialization of the world has resulted in severe environmental pollution, necessitating the development of new materials such as pollution remediation. Two-dimensional (2D) MXenes have emerged as a promising family of materials due to their unique physicochemical properties, making…
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Obesity and breast cancer: exploring the nexus of chronic inflammation, metabolic dysregulation, and nutritional strategies
The global prevalence of obesity has risen to epidemic proportions, posing significant health challenges across populations and contributing to increased morbidity and mortality from non-communicable diseases. Among its many consequences, obesity is now firmly established as a modifiable risk…