4 hasil untuk "Aaron Simoni"
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Artikel Jurnal
PTEN modulates urinary tract infection susceptibility and shapes urothelial antibacterial defenses
This study reveals that PTEN modulates bladder urothelial immunity by regulating Akt, NFκB, and FAK signaling, shaping susceptibility to urinary tract infection. Despite advancements in our understanding of urinary tract infection (UTI) pathogenesis, UTIs remain a leading cause of morbidity, partly…
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Artikel Jurnal
Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling
Summary: Obesity is a significant public health concern associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms driving increased infection risk remain unclear. Using a diet-induced obesity mouse model in male and female C57BL/6 mice, we show that…
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Artikel Jurnal
Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection
Summary: Urinary tract infections (UTIs) commonly afflict people with diabetes. To better understand the mechanisms that predispose diabetics to UTIs, we employ diabetic mouse models and altered insulin signaling to show that insulin receptor (IR) shapes UTI defenses. Our findings are validated in…
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Artikel Jurnal
Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury
Objective: Energy-intensive kidney reabsorption processes essential for normal whole-body function are maintained by tubular epithelial cell metabolism. Although tubular metabolism changes markedly following acute kidney injury (AKI), it remains unclear which metabolic alterations are beneficial or…