21 hasil untuk "Andreas Humpe"
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Artikel Jurnal Teks lengkap
Bridge Inspection with an Off-the-Shelf 360° Camera Drone
The author proposes a new approach for bridge crack detection by a 360° camera on top of a drone. Traditionally, bridge inspection is performed manually and although the use of drones has been implemented before, researchers used standard high definition cameras underneath the drone. To make the…
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Millionaire spending incompatible with 1.5 °C ambitions
Much evidence suggests that the wealthiest individuals contribute disproportionally to climate change. Here we study the implications of a continued growth in the number of millionaires for emissions, and its impact on the depletion of the remaining carbon budget to limit global warming to 1.5 °C…
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The social cost of carbon falling on the wealthy
Under the Paris Agreement, the responsibility for reducing greenhouse gas emissions lies with individual countries, which submit pledges to the United Nations Framework Convention on Climate Change (UNFCCC) outlining their ambitions and timelines for emission reductions. Within countries, emissions…
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Macroeconomic variables and long-term stock market performance. A panel ARDL cointegration approach for G7 countries
Based on the present value model for stock prices, we utilise a pooled mean group estimator for panel ARDL cointegration to estimate the long-run relationship between G7 stock prices and macroeconomic variables over the last 40 years. We find a positive long-run relation between stock prices…
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Balancing Predictive Performance and Interpretability in Machine Learning: A Scoring System and an Empirical Study in Traffic Prediction
This paper investigates the empirical relationship between predictive performance, often called predictive power, and interpretability of various Machine Learning algorithms, focusing on bicycle traffic data from four cities. As Machine Learning algorithms become increasingly embedded in…
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Private aviation is making a growing contribution to climate change
Abstract Commercial aviation’s contribution to climate change is growing, but the global role of private aviation is not well quantified. Here we calculate the sector’s CO2 emissions, using flight tracker data from the ADS-B Exchange platform for the period 2019 to 2023. Flight times for 25,993…
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The global scale, distribution and growth of aviation: Implications for climate change
Prior to the COVID-19 crisis, global air transport demand was expected to triple between 2020 and 2050. The pandemic, which reduced global air travel significantly, provides an opportunity to discuss the scale, distribution and growth of aviation until 2018, also with a view to consider the climate…
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COVID-19 and pathways to low-carbon air transport until 2050
The COVID-19 pandemic has led to an unprecedented decline in global air transport and associated reduction in CO _2 emissions. The International Civil Aviation Organization (ICAO) reacted by weakening its own CO _2 -offsetting rules. Here we investigate whether the pandemic can be an opportunity to…
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Keeping older people mobile: Autonomous transport services in rural areas
Rural areas are characterized by limited access to public transportation. In the absence of alternatives, many older people continue to drive private cars. This imposes risks on society and older people, as traffic risks increase with declining mental and physical health. As opportunities to remain…
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Leveraging Conversational Context for German Hate Speech Detection With Large Language Models
Hate speech and its increasing prevalence online pose a threat to individuals’ mental health and social cohesion and, together with regulatory pressure on platforms, are leading to a need for moderation. Current large language models (LLMs) show promising potential for hate speech detection due to…
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Large carbon dioxide emissions avoidance potential in improved commercial air transport efficiency
Abstract Aviation’s climate impact continues to grow, with little progress toward emission reductions aligned with global targets. While technological advances attract attention, operational efficiency across aircraft, airlines, airports, city pairs, and regions remains underexplored. Here we…
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Perspectives of targeting LILRB1 in innate and adaptive immune checkpoint therapy of cancer
Immune checkpoint blockade is a compelling approach in tumor immunotherapy. Blocking inhibitory pathways in T cells has demonstrated clinical efficacy in different types of cancer and may hold potential to also stimulate innate immune responses. A novel emerging potential target for immune…
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Adaptation and validation of the neighbourhood environment walkability scale for German-speaking youth (NEWS-Y-G)
Abstract Background Adolescents’ physical activity is related to characteristics of their neighbourhood environment. Understanding this relationship can help identify ways to promote this important health-related behaviour. The Neighbourhood Environment Walkability Scale for Youth (NEWS-Y) is the…
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Artikel Jurnal Teks lengkap
Enhanced ADCC Activity of Affinity Maturated and Fc-Engineered Mini-Antibodies Directed against the AML Stem Cell Antigen CD96
CD96, a cell surface antigen recently described to be preferentially expressed on acute myeloid leukemia (AML) leukemic stem cells (LSC) may represent an interesting target structure for the development of antibody-based therapeutic approaches. The v-regions from the CD96-specific hybridoma TH-111…
Juga tersedia di: DOAJ
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Artikel Jurnal Teks lengkap
Enhancing CDC and ADCC of CD19 Antibodies by Combining Fc Protein-Engineering with Fc Glyco-Engineering
Background: Native cluster of differentiation (CD) 19 targeting antibodies are poorly effective in triggering antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which are crucial effector functions of therapeutic antibodies in cancer immunotherapy…
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SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells
Abstract Background Acute myeloid leukaemia (AML) stem cells (LSCs) cause disease relapse. The CD47 “don’t eat me signal” is upregulated on LSCs and contributes to immune evasion by inhibiting phagocytosis through interacting with myeloid-specific signal regulatory protein alpha (SIRPα). Activation…
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Enhanced potency of immunotherapy against B‐cell precursor acute lymphoblastic leukemia by combination of an Fc‐engineered CD19 antibody and CD47 blockade
Abstract CD19‐directed immunotherapy has become a cornerstone in the therapy of B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). CD19‐directed cellular and antibody‐based therapeutics have entered therapy of primary and relapsed disease and contributed to improved outcomes in relapsed…
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Novel NKG2D-directed bispecific antibodies enhance antibody-mediated killing of malignant B cells by NK cells and T cells
The activating receptor natural killer group 2, member D (NKG2D) represents an attractive target for immunotherapy as it exerts a crucial role in cancer immunosurveillance by regulating the activity of cytotoxic lymphocytes. In this study, a panel of novel NKG2D-specific single-chain fragments…
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High-Risk HLA-DQ Mismatches Are Associated With Adverse Outcomes After Lung Transplantation
Human leukocyte antigen (HLA) mismatches (MM) between donor and recipient lead to eplet MM (epMM) in lung transplantation (LTX), which can induce the development of de-novo donor-specific HLA-antibodies (dnDSA), particularly HLA-DQ-dnDSA. Aim of our study was to identify risk factors for…