6 hasil untuk "Chenchen Pi"

Sirt3 Attenuates Oxidative Stress Damage and Rescues Cellular Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Superoxide Dismutase 2

Cao Ma; Yanan Sun; Chenchen Pi dkk.

Frontiers in Cell and Developmental Biology, Vol. 8 · 2020 · Inggris · DOAJ Scopus

Oxidative stress is one of the main causes of aging. The process of physiological aging is always accompanied by increased levels of endogenous oxidative stress. Exogenous oxidants have contributed to premature cellular senescence. As a deacetylase located in mitochondrial matrix, Sirt3 plays…

Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1

Cao Ma; Chenchen Pi; Yue Yang dkk.

PLOS ONE, Vol. 12 No. 1 · 2017 · Inggris · PLOS Scopus

Senescence restricts the development of applications involving mesenchymal stem cells (MSCs) in research fields, such as tissue engineering, and stem cell therapeutic strategies. Understanding the mechanisms underlying natural aging processes may contribute to the development of novel approaches to…

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PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy

Chen Chen; Jianan Ma; Chenchen Pi dkk.

Cell Discovery, Vol. 9 No. 1 · 2023 · Inggris · DOAJ Scopus

Abstract IL-10+ regulatory B cells (Bregs) play a significant role in cancer immunotherapy and their presence is an indicator of negative outcome. We found that PPARδ is significantly upregulated in tumor-induced IL-10+ Bregs with a phenotype of CD19+CD24hiIgDlo/−CD38lo or CD19+CD24hiIgDlo/−CD38hi…

Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease

Yanan Sun; Cao Ma; Hui Sun dkk.

Journal of Diabetes Research, Vol. 2020 · 2020 · Inggris · DOAJ Scopus

As a chronic metabolic disease, diabetes mellitus (DM) is broadly characterized by elevated levels of blood glucose. Novel epidemiological studies demonstrate that some diabetic patients have an increased risk of developing dementia compared with healthy individuals. Alzheimer’s disease (AD) is the…

MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD+-Sirt1 pathway

Chenchen Pi; Cao Ma; Huan Wang dkk.

Stem Cell Research & Therapy, Vol. 12 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract Background Expansion-mediated replicative senescence and age-related natural senescence have adverse effects on mesenchymal stem cell (MSC) regenerative capability and functionality, thus severely impairing the extensive applications of MSC-based therapies. Emerging evidences suggest that…