19 hasil untuk "David Fitzpatrick"
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Artikel Jurnal
Development of visual response selectivity in cortical GABAergic interneurons
Excitatory neurons in the carnivore and primate visual cortex display orientation selectivity arranged in a modular fashion before the onset of visual experience, but the developmental timeline for visual response selectivity of inhibitory neurons is unknown. Using in vivo calcium imaging in ferret…
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Artikel Jurnal
What and Where: Location-Dependent Feature Sensitivity as a Canonical Organizing Principle of the Visual System
Traditionally, functional representations in early visual areas are conceived as retinotopic maps preserving ego-centric spatial location information while ensuring that other stimulus features are uniformly represented for all locations in space. Recent results challenge this framework of…
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Artikel Jurnal
The feasibility, acceptability and preliminary testing of a novel, low-tech intervention to improve pre-hospital data recording for pre-alert and handover to the Emergency Department
Abstract Background Poor communication during patient handover is recognised internationally as a root cause of a significant proportion of preventable deaths. Data used in handover is not always easily recorded using ambulance based tablets, particularly in time-critical cases. Paramedics have…
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Artikel Jurnal
Effect of Calcium Triphosphate Cement on Proximal Humeral Fracture Osteosynthesis: A Finite Element Analysis
Purpose. To measure the effect of void-filling calcium triphosphate cement on the loads at the implant-bone interface of a proximal humeral fracture osteosynthesis using a finite element analysis. Methods. Finite element models of a 3-part proximal humeral fracture fixed with a plate with and…
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Artikel Jurnal
Effect of Calcium Triphosphate Cement on Proximal Humeral Fracture Osteosynthesis: A Cadaveric Biomechanical Study
Purpose. To evaluate the effect of filling a central humeral bone void with calcium triphosphate cement on the strength and stability of an osteosynthesis in elderly cadavers. Methods. 14 fresh cadaveric shoulder specimens obtained from 11 donors (mean age, 91.5 years; mean body weight, 61 kg) were…
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Artikel Jurnal
Locking Plate Fixation with and without Inferomedial Screws for Proximal Humeral Fractures: A Biomechanical Study
Purpose. To compare the efficacy of locking plate fixation with and without inferomedial screws in maintaining the reduction of a proximal humeral fracture. Methods. 22 synthetic humerus models were used. A standardised 3-part proximal humeral fracture with a 4-mm wedge segment was created and…
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Artikel Jurnal
Challenges and lessons learned in conducting international paramedic research: A scholarly perspective
Over the past two decades, paramedicine research has expanded significantly. While much of this work has been conducted within individual countries, there is now a critical need to foster international collaboration to improve knowledge synthesis and dissemination. This perspective paper draws on…
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Artikel Jurnal
Critcomms: a national cross-sectional questionnaire based study to investigate prehospital handover practices between ambulance clinicians and specialist prehospital teams in Scotland
Abstract Background Poor communication during patient handover is recognised internationally as a root cause of a significant proportion of preventable deaths. Improving the accuracy and quality of handover may reduce associated mortality and morbidity. Although the practice of handover between…
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Artikel Jurnal
An unsupervised learning approach to optimising tumour therapy through clinical data mining
Clinical data mining and healthcare analytics enable systematic evaluation of treatment strategies in precision oncology. This study analysed a harmonised multi-centre dataset of 150 patients treated with linac-based stereotactic radiosurgery for vestibular schwannoma across three institutions in…
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Artikel Jurnal
Glioblastoma Multiforme in the over 70's: “To treat or not to treat with radiotherapy?”
Abstract Background The incidence of Glioblastoma Multiforme (GBM) is increasing among the older population and is associated with poor prognosis. Management guidelines are lacking in this group. The purpose of this study was to analyze survival data and determine predictors of survival in patients…
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Artikel Jurnal
Temporal changes in frequency of severe hypoglycemia treated by emergency medical services in types 1 and 2 diabetes: a population-based data-linkage cohort study
Abstract Background Almost 20 years ago, the frequencies of severe hypoglycemia requiring emergency medical treatment were reported in people with types 1 and 2 diabetes in the Tayside region of Scotland. With subsequent improvements in the treatment of diabetes, concurrent with changes in the…
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Artikel Jurnal
Epidemiology of emergency ambulance service calls related to COVID-19 in Scotland: a national record linkage study
Abstract Background COVID-19 has overwhelmed health services across the world; its global death toll has exceeded 5.3 million and continues to grow. There have been almost 15 million cases of COVID-19 in the UK. The need for rapid accurate identification, appropriate clinical care and decision…
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Artikel Jurnal
Epidemiology of emergency ambulance service calls related to mental health problems and self harm: a national record linkage study
Abstract Background People experiencing a mental health crisis receive variable and poorer quality care than those experiencing a physical health crisis. Little is known about the epidemiology, subsequent care pathways of mental health and self-harm emergencies attended by ambulance services, and…
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Artikel Jurnal
A novel wireless implant for central venous pressure measurement: First animal experience
Background/Objective: Central venous pressure (CVP) serves as a surrogate for right atrial pressure, and thus could potentially predict a wider range of heart failure conditions. The purpose of this work is to assess CVP, through an implantable sensor incorporated with a novel anchor design, in the…
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Artikel Jurnal Teks lengkap
A Male with Unilateral Microphthalmia Reveals a Role for TMX3 in Eye Development
Anophthalmia and microphthalmia are important birth defects, but their pathogenesis remains incompletely understood. We studied a patient with severe unilateral microphthalmia who had a 2.7 Mb deletion at chromosome 18q22.1 that was inherited from his mother. In-situ hybridization showed that one…
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Artikel Jurnal
Electronic health records in ambulances: the ERA multiple-methods study
Background: Ambulance services have a vital role in the shift towards the delivery of health care outside hospitals, when this is better for patients, by offering alternatives to transfer to the emergency department. The introduction of information technology in ambulance services to electronically…