9 hasil untuk "David Mathar"
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Artikel Jurnal
Gambling Environment Exposure Increases Temporal Discounting but Improves Model-Based Control in Regular Slot-Machine Gamblers
Gambling disorder is a behavioral addiction that negatively impacts personal finances, work, relationships and mental health. In this pre-registered study (https://osf.io/5ptz9/) we investigated the impact of real-life gambling environments on two computational markers of addiction, temporal…
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Artikel Jurnal
Signatures of Perseveration and Heuristic-Based Directed Exploration in Two-Step Sequential Decision Task Behaviour
Processes formalized in classic Reinforcement Learning (RL) theory, such as model-based (MB) control, habit formation, and exploration have proven fertile in cognitive and computational neuroscience, as well as computational psychiatry. Dysregulations in MB control and exploration and their…
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Artikel Jurnal
Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making
Involvement of dopamine in regulating exploration during decision-making has long been hypothesized, but direct causal evidence in humans is still lacking. Here, we use a combination of computational modeling, pharmacological intervention and functional magnetic resonance imaging to address this…
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Artikel Jurnal Teks lengkap
Dopamine release, diffusion and uptake: A computational model for synaptic and volume transmission.
Computational modeling of dopamine transmission is challenged by complex underlying mechanisms. Here we present a new computational model that (I) simultaneously regards release, diffusion and uptake of dopamine, (II) considers multiple terminal release events and (III) comprises both synaptic and…
Juga tersedia di: PLOS
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Artikel Jurnal Teks lengkap
The catecholamine precursor Tyrosine reduces autonomic arousal and decreases decision thresholds in reinforcement learning and temporal discounting.
Supplementation with the catecholamine precursor L-Tyrosine might enhance cognitive performance, but overall findings are mixed. Here, we investigate the effect of a single dose of tyrosine (2g) vs. placebo on two catecholamine-dependent trans-diagnostic traits: model-based control during…
Juga tersedia di: PLOS
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Artikel Jurnal Teks lengkap
Catecholamine precursor modulation of human exploration: Evidence from a large gender-balanced sample
The catecholamine precursor Tyrosine has been linked to improved cognitive performance, but investigations into decision-making and reinforcement learning processes known to be under catecholamine control are sparse. We examined the impact of a single dose of Tyrosine (2g) on reinforcement learning…
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Artikel Jurnal
Dopamine regulates decision thresholds in human reinforcement learning in males
Abstract Dopamine fundamentally contributes to reinforcement learning, but recent accounts also suggest a contribution to specific action selection mechanisms and the regulation of response vigour. Here, we examine dopaminergic mechanisms underlying human reinforcement learning and action selection…