13 results for "Edi Simoni"

Correction: Coenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats

Laura Astolfi; Edi Simoni; Filippo Valente et al.

PLOS ONE, Vol. 12 No. 9 · 2017 · English · PLOS Scopus

[This corrects the article DOI: 10.1371/journal.pone.0162106.].

Also available at: DOAJ

Coenzyme Q10 plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats

Laura Astolfi; Edi Simoni; Filippo Valente et al.

PLOS ONE, Vol. 11 No. 9 · 2016 · English · PLOS Scopus

Cisplatin (Cpt) is known to induce a high level of oxidative stress, resulting in an increase of reactive oxygen species damaging the inner ear and causing hearing loss at high frequencies. Studies on animal models show that antioxidants may lower Cpt-induced ototoxicity. The aim of this study is…

Also available at: DOAJ

Immune Response After Cochlear Implantation

Edi Simoni; Erica Gentilin; Mariarita Candito et al.

Frontiers in Neurology, Vol. 11 · 2020 · English · DOAJ Scopus

A cochlear implant (CI) is an electronic device that enables hearing recovery in patients with severe to profound hearing loss. Although CIs are a successful treatment for profound hearing impairment, their effectivity may be improved by reducing damages associated with insertion of electrodes in…

Innate Immune Encapsulation Allows Gonadal Tolerance to Anisakis simplex (s.s.) Infection in Atlantic mackerel (Scomber scombrus)

Bahram Sayyaf Dezfuli; Flavio Pironi; Emanuela Franchella et al.

Fishes, Vol. 11 No. 8 · 2026 · English · DOAJ Scopus

Most of the publications on Anisakis simplex (Rudolphi, 1809) focus upon systematic aspects and zoonotic risk but there is lack of detailed information on infection and cellular immune response of the gonads. The current investigation detected whether gonadal infection by A. simplex affects…

Novel POU3F4 variants identified in patients with inner ear malformations exhibit aberrant cellular distribution and lack of SLC6A20 transcriptional upregulation

Emanuele Bernardinelli; Sebastian Roesch; Edi Simoni et al.

Frontiers in Molecular Neuroscience, Vol. 15 · 2022 · English · DOAJ Scopus

Hearing loss (HL) is the most common sensory defect and affects 450 million people worldwide in a disabling form. Pathogenic sequence alterations in the POU3F4 gene, which encodes a transcription factor, are causative of the most common type of X-linked deafness (X-linked deafness type 3, DFN3…

Detection of Lymphatic Vessels in the Superficial Fascia of the Abdomen

Giovanna Albertin; Laura Astolfi; Caterina Fede et al.

Life, Vol. 13 No. 3 · 2023 · English · DOAJ Scopus

Recently, the superficial fascia has been recognized as a specific anatomical structure between the two adipose layers—the superficial adipose tissue (SAT) and the deep adipose tissue (DAT). The evaluation of specific characteristics of cells, fibers, blood circulation, and innervation has shown…

miR-199a-3p increases the anti-tumor activity of palbociclib in liver cancer models

Elisa Callegari; Paola Guerriero; Cristian Bassi et al.

Molecular Therapy: Nucleic Acids, Vol. 29 · 2022 · English · DOAJ Scopus

Palbociclib is in early-stage clinical testing in advanced hepatocellular carcinoma (HCC). Here, we investigated whether the anti-tumor activity of palbociclib, which prevents the CDK4/6-mediated phosphorylation of RB1 but simultaneously activates AKT signaling, could be improved by its combination…

Also available at: DOAJ

Evaluation of Ototoxic Effects of Cisplatin in a Rat Model: A Dose–Response Study

Filippo Hellies; Silvia Fracaro; Giovanni Pintus et al.

Applied Sciences, Vol. 15 No. 3 · 2025 · English · DOAJ Scopus

Cisplatin (cis-diclorodiamminoplatin, CDDP) is a common chemotherapeutic agent for solid tumors, but its use is limited by severe side effects such as ototoxicity and nephrotoxicity. Variability in CDDP dosing and administration, along with high mortality and sensitivity in animal models…

Cochlear Repair by Transplantation of Human Cord Blood CD133+ Cells to Nod-Scid Mice Made Deaf with Kanamycin and Noise

Roberto P. Revoltella M.D., Ph.D.; Sandra Papini; Alfredo Rosellini et al.

Cell Transplantation, Vol. 17 · 2008 · English · DOAJ Scopus

We investigated the fate of human cord blood CD133+ hematopoietic stem cells (HSC) transplanted intravenously (IV) into irradiated nodscid mice previously made deaf by ototoxic treatment with kanamycin and/or intense noise, to verify whether HSC engraft the cochlea and contribute to inner ear…

Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancer

Silvia Sabbioni; Paola Guerriero; Ram C. Shankaraiah et al.

Cell Death Discovery, Vol. 12 No. 1 · 2026 · English · DOAJ Scopus

Abstract Hepatocellular carcinoma (HCC) is one of the most common cancers and the third leading cause of cancer-related death worldwide. The prognosis is poor, with a median survival of 12–15 months in patients with advanced-stage disease. Early diagnosis and the development of new, more effective…