48 results for "Fotios Dimitriadis"

Effect of testosterone replacement treatment on constitutional and sexual symptoms in type 2 diabetic men: need for rules

Fotios Dimitriadis; Nikolaos Sofikitis

Asian Journal of Andrology, Vol. 17 No. 2 · 2015 · English · DOAJ Scopus

In a recent publication, Gianatti and colleagues investigated the effect of testosterone treatment in obese, aging men with type 2 diabetes (T2D) with mild to moderate symptoms, a modest reduction in testosterone levels, mild to moderate aging male symptoms, and erectile dysfunction. [1] The…

Commentary on: “Human umbilical cord wharton's jelly-derived mesenchymal stem cell transplantation could improve diabetic intracavernosal pressure”

Fotios Dimitriadis; Vasileios Palapelas; Athanasios Zachariou et al.

Asian Journal of Andrology, Vol. 24 No. 2 · 2022 · English · DOAJ Scopus

Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway

Aris Kaltsas; Stamatis Papaharitou; Fotios Dimitriadis et al.

Biomedicines, Vol. 14 No. 2 · 2026 · English · DOAJ Scopus

Psychological stress is increasingly investigated as a potentially modifiable factor in male infertility, in part through oxidative stress. This narrative review synthesizes mechanistic and translational evidence linking stress-related neuroendocrine activation and coping behaviors with redox…

Transurethral resection of a bladder trigone leiomyoma: a rare case report

Athanasios Zachariou; Maria Filiponi; Fotios Dimitriadis et al.

BMC Urology, Vol. 20 No. 1 · 2020 · English · DOAJ Scopus

Abstract Background Bladder leiomyomas are rare and benign tumors of the bladder. They account for 0.43% of all bladder tumors, and only 250 cases have been reported in English literature. Based on the size and localization of the lesion, their symptoms vary considerably. Women seem to be more…

Predictive Value of Varicocele Grade and Histopathology in Simultaneous Varicocelectomy and Sperm Retrieval in Non-Obstructive Azoospermia: A Retrospective Cohort Study

Aris Kaltsas; Fotios Dimitriadis; Michael Chrisofos et al.

Medicina, Vol. 60 No. 12 · 2024 · English · DOAJ Scopus

Background and Objectives: Varicocele repair in men with non-obstructive azoospermia (NOA) remains a subject of debate due to inconsistent outcomes. This study aimed to evaluate the impact of microsurgical varicocelectomy on sperm recovery rates in men with NOA and to assess the role of varicocele…

Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management

Aris Kaltsas; Fotios Dimitriadis; Athanasios Zachariou et al.

Cells, Vol. 14 No. 2 · 2025 · English · DOAJ Scopus

Phosphodiesterases, particularly the type 5 isoform (PDE5), have gained recognition as pivotal regulators of male reproductive physiology, exerting significant influence on testicular function, sperm maturation, and overall fertility potential. Over the past several decades, investigations have…

Empirical Treatments for Male Infertility: A Focus on Lifestyle Modifications and Medicines

Aris Kaltsas; Athanasios Zachariou; Fotios Dimitriadis et al.

Diseases, Vol. 12 No. 9 · 2024 · English · DOAJ Scopus

Background/Objectives: Male infertility is a prevalent issue impacting numerous couples worldwide. This review aims to evaluate the effectiveness of empirical therapies for male infertility, focusing on both lifestyle modifications and medical treatments. This study provides a comprehensive…

The Effect of Low-Intensity Extracorporeal Shockwave Treatment on the Urinary Bladder in an Experimental Diabetic Rat Model

Fotios Dimitriadis; Maria Papaioannou; Ioannis Sokolakis et al.

International Neurourology Journal, Vol. 25 No. 1 · 2021 · English · DOAJ Scopus

Purpose Preclinical data increasingly support an impact of low-intensity extracorporeal shockwave therapy (Li-ESWT) on the bladder. We investigated the molecular effects of Li-ESWT on the bladder of a streptozotocin-induced diabetic rat model. Methods Fifteen 8-week-old male Wistar rats were…

When Testosterone Fades: Leydig Cell Aging Shaped by Environmental Toxicants, Metabolic Dysfunction, and Testicular Niche Crosstalk

Aris Kaltsas; Fotios Dimitriadis; Athanasios Zachariou et al.

Cells, Vol. 15 No. 2 · 2026 · English · DOAJ Scopus

Declining Leydig cell steroidogenesis contributes to late-onset hypogonadism and to age-associated impairment of male reproductive health. Determinants of dysfunction extend beyond chronological aging. This review synthesizes recent experimental and translational evidence on cellular and molecular…

Evaluating the Impact of Benign Prostatic Hyperplasia Surgical Treatments on Sexual Health

Aris Kaltsas; Zisis Kratiras; Athanasios Zachariou et al.

Biomedicines, Vol. 12 No. 1 · 2024 · English · DOAJ Scopus

Benign prostatic hyperplasia (BPH), a prevalent condition in older men, is often managed through various surgical interventions. This narrative review aims to explore the impact of these surgical treatments on sexual function, a critical aspect of patient quality of life often overlooked in BPH…

Antioxidant Supplementation on Male Fertility—A Systematic Review

Fotios Dimitriadis; Hendrik Borgmann; Julian P. Struck et al.

Antioxidants, Vol. 12 No. 4 · 2023 · English · DOAJ Scopus

Our aim was to review the current literature regarding the effect of antioxidant supplementation (AS) on male fertility parameters, as AS is commonly used to treat male infertility due to the availability and affordability of antioxidants in many parts of the world. Materials and methods: PubMed…

Paternal Contributions to Recurrent Pregnancy Loss: Mechanisms, Biomarkers, and Therapeutic Approaches

Aris Kaltsas; Athanasios Zikopoulos; Vladimir Kojovic et al.

Medicina, Vol. 60 No. 12 · 2024 · English · DOAJ Scopus

Background and Objectives: Recurrent pregnancy loss (RPL) affects numerous couples worldwide and has traditionally been attributed mainly to maternal factors. However, recent evidence highlights significant paternal influences on pregnancy viability and outcomes. This review aims to comprehensively…

Phospholipase Cζ, the Molecular Spark of Fertilization and Male Infertility: Insights from Bench to Bedside

Aris Kaltsas; Maria-Anna Kyrgiafini; Zissis Mamuris et al.

Medicina, Vol. 61 No. 6 · 2025 · English · DOAJ Scopus

Phospholipase C zeta (PLCζ) has emerged as a pivotal sperm-specific factor responsible for triggering oocyte activation, a process essential for successful fertilization and early embryogenesis. A narrative review was conducted to examine the molecular architecture and biochemical features of PLCζ…

Correction to: Transvaginal closure of urinary bladder opening and Mitrofanof technique in a neurologically impaired female with chronic indwelling catheter: a case presentation

Athanasios Zachariou; Minas Paschopoulos; Aris Kaltsas et al.

BMC Urology, Vol. 22 No. 1 · 2022 · English · DOAJ Scopus

The Silent Threat to Women’s Fertility: Uncovering the Devastating Effects of Oxidative Stress

Aris Kaltsas; Athanasios Zikopoulos; Efthalia Moustakli et al.

Antioxidants, Vol. 12 No. 8 · 2023 · English · DOAJ Scopus

Oxidative stress (OS), which arises through an imbalance between the formation of reactive oxygen species (ROS) and antioxidant defenses, plays a key role in the pathophysiology of female infertility, with the latter constituting just one of a number of diseases linked to OS as a potential cause…

Impact of antioxidants on seminal vesicles function and fertilizing potential in diabetic rats

Panagiota Tsounapi; Masashi Honda; Fotios Dimitriadis et al.

Asian Journal of Andrology, Vol. 19 No. 6 · 2017 · English · DOAJ Scopus

Diabetes mellitus significantly affects the male reproduction and sexual function. In the present study, we investigated the diabetes-induced dysfunction of seminal vesicles (SVs) in the diabetes-rat model and the role of antioxidants. Streptozotocin-induced diabetes after 4 weeks caused smaller…

Letrozole at the Crossroads of Efficacy and Fetal Safety in Ovulation Induction: A Narrative Review

Aris Kaltsas; Anna Efthimiou; Christos Roidos et al.

Biomedicines, Vol. 13 No. 9 · 2025 · English · DOAJ Scopus

Letrozole, a third-generation aromatase inhibitor initially developed for breast cancer, has become the preferred first-line agent for ovulation induction (OI), particularly in women with polycystic ovary syndrome (PCOS). This narrative review critically evaluates the efficacy, safety, and clinical…

Telemedicine in Urology: Where Have We Been and Where Are We Heading?

Evangelos N. Symeonidis; Domenico Veneziano; Hendrik Borgmann et al.

European Urology Open Science, Vol. 50 · 2023 · English · DOAJ Scopus

Context: Humanity is facing significant challenges, and in 2019, a new coronavirus caused an unprecedented global disease outbreak. The coronavirus disease 2019 (COVID-19) pandemic vastly impacted health care delivery, generating devastating economic, social, and public health disruption. Although…

Varicoceles in Men With Non-obstructive Azoospermia: The Dilemma to Operate or Not

Aris Kaltsas; Eleftheria Markou; Athanasios Zachariou et al.

Frontiers in Reproductive Health, Vol. 4 · 2022 · English · DOAJ Scopus

The knowledge on male reproduction is constantly expanding, especially in treating infertility due to non-obstructive azoospermia (NOA). Varicocele is occasionally diagnosed in a subpopulation of males with NOA. Varicocele repair in NOA-men may contribute to the reappearance of spermatozoa in…

Predictors of Successful Testicular Sperm Extraction: A New Era for Men with Non-Obstructive Azoospermia

Aris Kaltsas; Sofoklis Stavros; Zisis Kratiras et al.

Biomedicines, Vol. 12 No. 12 · 2024 · English · DOAJ Scopus

Background/Objectives: Non-obstructive azoospermia (NOA) is a severe form of male infertility characterized by the absence of sperm in the ejaculate due to impaired spermatogenesis. Testicular sperm extraction (TESE) combined with intracytoplasmic sperm injection is the primary treatment, but…