7 hasil untuk "Gabriel Foley"

The GMC superfamily of oxidoreductases revisited: analysis and evolution of fungal GMC oxidoreductases

Leander Sützl; Gabriel Foley; Elizabeth M J Gillam dkk.

Biotechnology for Biofuels, Vol. 12 No. 1 · 2019 · Inggris · DOAJ

Abstract Background The glucose–methanol–choline (GMC) superfamily is a large and functionally diverse family of oxidoreductases that share a common structural fold. Fungal members of this superfamily that are characterised and relevant for lignocellulose degradation include aryl-alcohol…

SeqScrub: a web tool for automatic cleaning and annotation of FASTA file headers for bioinformatic applications

Gabriel Foley; Leander Sützl; Stephlina A D'Cunha dkk.

BioTechniques, Vol. 67 No. 2 · 2019 · Inggris · DOAJ Scopus

Data consistency is necessary for effective bioinformatic analysis. SeqScrub is a web tool that parses and maintains consistent information about protein and DNA sequences in FASTA file format, checks if records are current, and adds taxonomic information by matching identifiers against entries in…

Structure and function of the TIR domain from the grape NLR protein RPV1

Simon John Williams; Ling YIn; Gabriel Foley dkk.

Frontiers in Plant Science, Vol. 7 · 2016 · Inggris · DOAJ Scopus

The N-terminal Toll/interleukin-1 receptor/resistance protein (TIR) domain has been shown to be both necessary and sufficient for defence signalling in the model plants flax and Arabidopsis. In examples from these organisms, TIR domain self-association is required for signalling function, albeit…

Thermostable ancestors enabled evolutionary diversification of promiscuous chemical defence enzymes

Raine E S Thomson; Yosephine Gumulya; Anthony W Bengochea dkk.

The EMBO Journal, Vol. 45 No. 9 · 2026 · Inggris · DOAJ Scopus

Abstract Enzymes are generally believed to evolve from promiscuous ancestors to more specialized descendants under some selection pressure related to their function. However, enzymes whose function depends on substrate promiscuity have not been studied. Here, we show that a group of highly diverse…

Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins

Yu Shang Low; Solace G. Roche; Nadezhda A. Aleksandrova dkk.

Nature Communications, Vol. 16 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract ABC toxins are toxin-translocating, pore-forming proteins found in a wide range of insecticidal bacteria and some mammalian pathogens. The Yersinia entomopahaga toxin complex (YenTc) belongs to a distinct subclass of ABC toxins, defined by a divergent molecular architecture. Structural…

Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP)

Gabriel Foley; Ariane Mora; Connie M. Ross dkk.

PLOS Computational Biology, Vol. 18 No. 10 · 2022 · Inggris · PLOS Scopus

Ancestral sequence reconstruction is a technique that is gaining widespread use in molecular evolution studies and protein engineering. Accurate reconstruction requires the ability to handle appropriately large numbers of sequences, as well as insertion and deletion (indel) events, but available…

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