52 hasil untuk "Kerry Woolfall"
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Artikel Jurnal Teks lengkap
Relative solidarity: Conceptualising communal participation in genomic research among potential research participants in a developing Sub-Saharan African setting
Objective: As genomic research gathers momentum in sub-Saharan Africa, it has become increasingly important to understand the reasons why individuals wish to participate in this kind of medical research. Against the background of communitarianism conceived as typical of African communities, it is…
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Artikel Jurnal Teks lengkap
Correction: Relative solidarity: Conceptualising communal participation in genomic research among potential research participants in a developing Sub-Saharan African setting
[This corrects the article DOI: 10.1371/journal.pone.0195171.].
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Artikel Jurnal Teks lengkap
Parents’ Agendas in Paediatric Clinical Trial Recruitment Are Different from Researchers’ and Often Remain Unvoiced: A Qualitative Study
Ensuring parents make an informed decision about their child’s participation in a clinical trial is a challenge for practitioners as a parent’s comprehension of a trial may differ from that intended by the practitioners responsible for recruitment. We explored what issues parents consider important…
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Artikel Jurnal
Developing a Neonatal Pulmonary Hypertension Core Outcome Set (NeoPH COS)—A Study Protocol
ABSTRACT Pulmonary hypertension (PH) in newborn babies is a relatively rare, heterogeneous condition that has high associated mortality in the neonatal period and beyond. There are limited evidence‐based strategies to treat or prevent this condition. Over the last two decades, there has been an…
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Strategies to enhance recruitment and consent to intensive care studies: a qualitative study with researchers and patient–public involvement contributors
Objective Clinical trials and studies in intensive care units (ICUs) have complex consent processes and often encounter problems in recruiting patients. By interviewing research team members about the challenges in critical care research, we aimed to identify strategies to enhance recruitment and…
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Artikel Jurnal
Associations between parent–child relationship, and children’s externalizing and internalizing symptoms, and lifestyle behaviors in China during the COVID-19 epidemic
Abstract To investigate associations between parent–child relationships, children’s externalizing and internalizing symptoms, and lifestyle responses to the COVID-19 epidemic, we conducted an online survey of a random, representative sample of residents with children aged 3–17 years during…
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Artikel Jurnal
Questioning approaches to consent in time critical obstetric trials: findings from a mixed-methods study
Objective Trial legislation enables research to be conducted without prior consent (RWPC) in emergency situations, yet this approach has rarely been used in time-critical obstetric trials. This study explored views and experiences of antenatal recruitment and consent and RWPC in an emergency…
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Artikel Jurnal
Learning from stakeholders to inform good practice guidance on consent to research in intensive care units: a mixed-methods study
Objectives Obtaining informed consent from patients in intensive care units (ICUs) prior to enrolment in a study is practically and ethically complex. Decisions about the participation of critically ill patients in research often involve substitute decision makers (SDMs), such as a patient’s…
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Artikel Jurnal
Addressing the knowledge gap: development of stakeholder-informed training to improve the inclusion of adults with impaired capacity to consent in trials
Abstract Background Improving the inclusion of under-served groups in clinical trials is increasingly being seen as a priority area for research funders and regulators. Adults who lack capacity to make an informed decision about taking part in trials are recognised as an under-served group…
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Artikel Jurnal
Consent and recruitment: the reporting of paediatric trials published in 2012
Objectives We evaluated 300 paediatric trials to determine: the consent and recruitment strategies used, who trial information was targeted to, how incentives were used and if they achieved their recruitment targets.Methods For this cross-sectional evaluation, we searched the Cochrane Central…
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Artikel Jurnal
Balancing key stakeholder priorities and ethical principles to design a trial comparing intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregnancy: FERN qualitative study
Objectives As part of the FERN feasibility study, this qualitative research aimed to explore parents’ and clinicians’ views on the acceptability, feasibility and design of a randomised controlled trial (RCT) of active intervention versus expectant management in monochorionic (MC) diamniotic twin…
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Artikel Jurnal
Enhancing practitioners’ confidence in recruitment and consent in the EcLiPSE trial: a mixed-method evaluation of site training – a Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) study
Abstract Background EcLiPSE (Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children) is a randomised controlled trial (RCT) in the United Kingdom. Challenges to success include the need to immediately administer an intervention without informed consent and changes in…
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Artikel Jurnal
Enhancing communication with bereaved relatives about emergency and critical care trials (ENHANCE): a mixed-methods study
Objectives Clinical research in emergency and critical care is vital, but recruitment and consent are complex. Research may be conducted without prior consent when patients are critically ill, and interventions are time critical. Some patients may die before research participation can be discussed…
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Artikel Jurnal
Reporting of data monitoring committees and adverse events in paediatric trials: a descriptive analysis
Objectives For 300 paediatric trials, we evaluated the reporting of: a data monitoring committee (DMC); interim analyses, stopping rules and early stopping; and adverse events and harm-related endpoints.Methods For this cross-sectional evaluation, we randomly selected 300 paediatric trials…
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Artikel Jurnal
Complex and alternate consent pathways in clinical trials: methodological and ethical challenges encountered by underserved groups and a call to action
Abstract Background Informed consent is considered a fundamental requirement for participation in trials, yet obtaining consent is challenging in a number of populations and settings. This may be due to participants having communication or other disabilities, their capacity to consent fluctuates or…
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Artikel Jurnal
The PLANES study: a protocol for a randomised controlled feasibility study of the placental growth factor (PlGF) blood test-informed care versus standard care alone for women with a small for gestational age fetus at or after 32 + 0 weeks’ gestation
Abstract Background Stillbirth remains a major concern across the globe and in some high-resource countries, such as the UK; efforts to reduce the rate have achieved only modest reductions. One third of stillborn babies are small for gestational age (SGA), and these pregnancies are also at risk of…
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Artikel Jurnal
Non-invasive ventilation for the management of children with bronchiolitis (NOVEMBR): a feasibility study and core outcome set development protocol
Abstract Background Bronchiolitis is an acute lower respiratory infection which predominantly affects young children. Treatment for bronchiolitis is limited to supportive therapy. Nasal oxygen therapy is part of routine care, and delivery now incorporates varying levels of non-invasive continuous…