12 results for "Keyi Lu"
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Journal Article
Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells
Abnormal elevations in the mortality of intestinal epithelial cells (IECs) are indicative of intestinal inflammation. Necroptosis of IECs represents a pro-inflammatory form of cell death, and modulation of IECs necroptosis may mitigate subsequent intestinal inflammation and preserve the integrity…
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Nitraria sibirica Pall.: A Halophytic Resource for Antioxidant-Rich Functional Foods and Ecological Resilience
Nitraria sibirica Pall., a halophytic shrub native to arid and saline–alkaline ecosystems, represents a dual-purpose resource for ecological stabilization and functional food development. This review synthesizes current knowledge of its bioactive compounds and pharmacological properties, while…
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Celastrol ameliorates ulcerative colitis by inhibiting HSP90-mediated necroptosis of intestinal epithelial cells
IntroductionUlcerative colitis (UC) is a chronic inflammatory bowel disease characterized by intestinal barrier dysfunction and epithelial cell death. Necroptosis of intestinal epithelial cells (IECs) mediated by the RIPK1/RIPK3/MLKL pathway has emerged as a key driver of UC progression. Celastrol…
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Decreased Autophagy Contributes to Myocardial Dysfunction in Rats Subjected to Nonlethal Mechanical Trauma
Autophagy is important in cells for removing damaged organelles, such as mitochondria. Insufficient autophagy plays a critical role in tissue injury and organ dysfunction under a variety of pathological conditions. However, the role of autophagy in nonlethal traumatic cardiac damage remains…
Also available at: DOAJ
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Journal Article
Associations between folate metabolism biomarkers and cognitive impairment in older Chinese adults: a cross-sectional study
BackgroundThe role of folate metabolism–related biomarker profiles in age-related cognitive impairment (ARCI) remains unclear. This cross-sectional study aimed to examine the association between folate metabolism-related biomarkers and cognitive performance in older Chinese adults.MethodsWe…
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Decreased Autophagy in Rat Heart Induced by Anti-β1-Adrenergic Receptor Autoantibodies Contributes to the Decline in Mitochondrial Membrane Potential
It has been recognized that changes in mitochondrial structure plays a key role in development of cardiac dysfunction, and autophagy has been shown to exert maintenance of mitochondrial homeostasis effects. Our previous study found that anti-β1-adrenergic receptor autoantibodies (β1-AABs) could…
Also available at: DOAJ
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Journal Article
Amomum tsaoko extract from Nujiang alleviates DSS-induced colitis through inhibiting necroptosis
Necroptosis, a form of programmed cell death, plays a significant role in compromising the intestinal barrier and initiating intestinal inflammation. An analysis of data from the Gene Expression Omnibus (GEO) reveals a strong correlation between ulcerative colitis (UC) and the pathological…
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Journal Article
Quantitative assessment of graves’ ophthalmopathy activity using 99mTc-DTPA SPECT/CT orbital imaging: a feasibility study with multiple indicators
Abstract Background Graves' ophthalmopathy (GO) is a challenging autoimmune manifestation of Graves' disease, whose management relies on accurate assessment of inflammatory activity in the extraocular muscles (EOMs). The Clinical Activity Score (CAS), the current gold standard for assessing disease…
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Journal Article
ENO1 inhibition synergizes with chidamide to induce ferroptosis in PTCL-NOS through metabolic remodeling
Enolase (ENO1) is a key enzyme involved in glycolysis and plays an important role in various types of cancer. This study explored the role and mechanism of ENO1 and the histone deacetylase inhibitor chidamide in peripheral T cell lymphoma, not otherwise specified (PTCL-NOS). Reverse transcription…