6 results for "Marcin Gradowski"
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Journal Article Full text
The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases
Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic…
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Journal Article
KINtaro: protein kinase-like database
Abstract Objective The superfamily of protein kinases features a common Protein Kinase-like (PKL) three-dimensional fold. Proteins with PKL structure can also possess enzymatic activities other than protein phosphorylation, such as AMPylation or glutamylation. PKL proteins play a vital role in the…
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Journal Article
Chloroflexota in agricultural soils: current knowledge and future research directions
The review organizes current knowledge on the biofunctions, life-history strategies, and environmental responses of Chloroflexota in agricultural soils. Members of this phylum play key roles in carbon, nitrogen, and phosphorus cycling through a high degree of metabolic versatility, including…
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Journal Article
Pan-kinome of Legionella expanded by a bioinformatics survey
Abstract The pathogenic Legionella bacteria are notorious for delivering numerous effector proteins into the host cell with the aim of disturbing and hijacking cellular processes for their benefit. Despite intensive studies, many effectors remain uncharacterized. Motivated by the richness of…
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Journal Article Full text
A novel predicted ADP-ribosyltransferase-like family conserved in eukaryotic evolution
The presence of many completely uncharacterized proteins, even in well-studied organisms such as humans, seriously hampers full understanding of the functioning of the living cells. ADP-ribosylation is a common post-translational modification of proteins; also nucleic acids and small molecules can…
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Journal Article
Response of soil microbiota to various soil management practices in 100-year-old agriculture field and identification of potential bacterial ecological indicator
The study aimed to comprehensively investigate the structural dynamics of a soil microbial community within a 100-year agricultural field experiment. The experimental design encompasses three distinct soil management practices, namely monoculture, five–year rotation, and random rotation, each with…