12 results for "Maria Concetta Miniaci"
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Journal Article
Missing the egocentric spatial reference: a blank on the map [version 1; referees: 3 approved]
Egocentric (self-centered) and allocentric (viewpoint independent) representations of space are essential for spatial navigation and wayfinding. Deficits in spatial memory come with age-related cognitive decline, are marked in mild cognitive impairment (MCI) and Alzheimer’s disease (AD), and are…
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Journal Article Full text
The Role of Dopamine in Neurological, Psychiatric, and Metabolic Disorders and Cancer: A Complex Web of Interactions
Dopamine, a key neurotransmitter in the central nervous system, is essential for regulating a wide range of physiological processes, including motor control, reward processing, mood regulation, and decision-making [...]
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Modulation, plasticity and pathophysiology of the parallel fiber-Purkinje cell synapse
The parallel fiber-Purkinje cell synapse represents the point of maximal signal divergence in the cerebellar cortex with an estimated number of about 60 billion synaptic contacts in the rat and 100,000 billions in humans. At the same time, the Purkinje cell dendritic tree is a site of remarkable…
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A frugal printed electrochemical architecture to monitor dopamine release in mice brain: Organ-on-screen-printed approach
Dopamine (DA) is an important catecholamine neuromodulator that is present in the brain of mammal, and changes of its level can be related to some neurological diseases such as Parkinson, Huntington and Alzheimer. As a consequence, rapid, cost-effective and sensitive approaches are required to…
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Roles for the Dorsal Striatum in Aversive Behavior
The ability to identify and avoid environmental stimuli that signal danger is essential to survival. Our understanding of how the brain encodes aversive behaviors has been primarily focused on roles for the amygdala, hippocampus (HIPP), prefrontal cortex, ventral midbrain, and ventral striatum…
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Norepinephrine release in the cerebellum contributes to aversive learning
Abstract The modulation of dopamine release from midbrain projections to the striatum has long been demonstrated in reward-based learning, but the synaptic basis of aversive learning is far less characterized. The cerebellum receives axonal projections from the locus coeruleus, and norepinephrine…
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Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism
The formation of the complex cerebellar cortical circuits follows different phases, with initial synaptogenesis and subsequent processes of refinement guided by a variety of mechanisms. The regularity of the cellular and synaptic organization of the cerebellar cortex allowed detailed studies of the…
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Purkinje Cell Signaling Deficits in Animal Models of Ataxia
Purkinje cell (PC) dysfunction or degeneration is the most frequent finding in animal models with ataxic symptoms. Mutations affecting intrinsic membrane properties can lead to ataxia by altering the firing rate of PCs or their firing pattern. However, the relationship between specific firing…
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Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms
Stress profoundly affects physical and mental health, particularly when experienced early in life. Early-life stress (ELS) encompasses adverse childhood experiences such as abuse, neglect, violence, or chronic poverty. These stressors can induce long-lasting changes in brain structure and function…
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Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase
The c-Jun N-terminal kinase (JNK) is part of a stress signalling pathway strongly activated by NMDA-stimulation and involved in synaptic plasticity. Many studies have been focused on the post-synaptic mechanism of JNK action, and less is known about JNK presynaptic localization and its…
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Journal Article
The Emerging Role of Altered Cerebellar Synaptic Processing in Alzheimer’s Disease
The role of the cerebellum in Alzheimer’s disease (AD) has been neglected for a long time. Recent studies carried out using transgenic mouse models have demonstrated that amyloid-β (Aβ) is deposited in the cerebellum and affects synaptic transmission and plasticity, sometimes before plaque…
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Journal Article
Formyl peptide receptor 2 activation by MR-39 inhibits glioblastoma cell proliferation and invasiveness through suppression of multiple oncogenic pathways
Abstract Background Glioblastoma (GBM) is the most common, aggressive and poor prognosis malignant brain tumor in adults, that is still orphan of effective medical treatments. The formyl peptide receptor 2 (FPR2), a G protein– coupled receptor implicated in inflammation and cancer biology, has…