35 hasil untuk "Massimo Colombo"

Diagnosis of liver nodules within and outside screening programs

Massimo Colombo

Annals of Hepatology, Vol. 14 No. 3 · 2015 · Inggris · DOAJ Scopus

Evaluation of a liver nodule detected with ultrasound includes the recovery of a detailed medical history, a physical exam, appropriate contrast imaging examinations and, in selected cases, histopathology. In this setting, identification of liver disease accompanying a liver nodule helps…

Surveillance for hepatocellular carcinoma in patients with advanced liver fibrosis

Angelo Sangiovanni; Massimo Colombo

The Saudi Journal of Gastroenterology, Vol. 27 No. 2 · 2021 · Inggris · DOAJ Scopus

Surveillance is the only pragmatic approach to improve treatment of hepatocellular carcinoma (HCC) owing to the fact that it allows detection of the tumor at an early and better curable stage. International liver societies recommend surveillance with biannual abdominal ultrasound (US) for patients…

The impact of antiviral therapy on hepatocellular carcinoma epidemiology

Massimo Colombo; Ana Lleo

Hepatic Oncology, Vol. 5 No. 1 · 2018 · Inggris · DOAJ Scopus

The development of nucleos(t)ide analogs and direct antiviral agents has revolutionized the management of chronic infection with HBV and HCV, respectively. These regimens allow to expand treatment to virtually all infected, including those with poor hepatic reserve and those with severe…

Treatment for Viral Hepatitis as Secondary Prevention for Hepatocellular Carcinoma

Saleh A. Alqahtani; Massimo Colombo

Cells, Vol. 10 No. 11 · 2021 · Inggris · DOAJ Scopus

Chronic infections with either hepatitis B or C virus (HBV or HCV) are among the most common risk factors for developing hepatocellular carcinoma (HCC). The hepatocarcinogenic potential of these viruses is mediated through a wide range of mechanisms, including the induction of chronic inflammation…

HBV and HCV Therapy

Massimo Colombo; Pietro Lampertico; Mauro Viganò dkk.

Viruses, Vol. 1 No. 3 · 2009 · Inggris · DOAJ Scopus

One year of interferon therapy inhibits HBV replication in one third of the patients whereas long-term administration of oral nucleos(t)ide analogues is efficient in most of them, as long as early treatment adaptation in patients with partial virological response and resistance is provided…

High Serum Levels of HDV RNA Are Predictors of Cirrhosis and Liver Cancer in Patients with Chronic Hepatitis Delta

Raffaella Romeo; Barbara Foglieni; Giovanni Casazza dkk.

PLoS ONE, Vol. 9 No. 3 · 2014 · Inggris · PLOS Scopus

Chronic infection with the hepatitis delta virus (HDV) is a risk factor for cirrhosis and hepatocellular carcinoma (HCC), but little is known whether the outcome of hepatitis is predicted by serum markers of HDV and hepatitis B virus (HBV) infection. The aim of the study was to investigate these…

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The risk of liver cancer in autoimmune liver diseases

Ana Lleo; Ynto S. de Boer; Rodrigo Liberal dkk.

Therapeutic Advances in Medical Oncology, Vol. 11 · 2019 · Inggris · DOAJ Scopus

Hepatocellular carcinoma (HCC), the dominant primary malignancy of the liver, has almost invariably a fatal outcome that can be averted only by early diagnosis and treatment. While the close association of HCC with chronic viral hepatitis and alcohol abuse has impacted favourably on screening and…

Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report

Giovanni Covini; Elena Bredi; Salvatore Badalamenti dkk.

Hepatology Communications, Vol. 2 No. 10 · 2018 · Inggris · DOAJ Scopus

Abstract We report the case of a woman with chronic hepatitis C and idiopathic thrombocytopenic purpura (ITP) who developed autoimmune hepatitis (AIH) during antiviral therapy with ledipasvir (LDV)/sofosbuvir (SOF). The onset of acute hepatitis rose two weeks after starting treatment with LDV/SOF…

Cost analysis of residual viremia detected by two real-time PCR assays for response-guided (dual or triple) therapy of HCV genotype 1 infection

Alessio Aghemo; Giovanna Lunghi; Roberto Ravasio dkk.

Global & Regional Health Technology Assessment, Vol. 4 No. 1 · 2016 · Italia · DOAJ Scopus

Cost analysis of residual viremia detected by two real-time PCR assays for response-guided (dual or triple) therapy of HCV genotype 1 infectionIntroductionThe duration of interferon-based dual and triple therapies for HCV-G1 is determined by assessment of early viral kinetics. We conducted a cost…

Deciding on Interferon-Free Treatment for Chronic Hepatitis C: Updating Liver Stiffness Cut-Off Values to Maximize Benefit

Agostino Colli; Mirella Fraquelli; Daniele Prati dkk.

PLOS ONE, Vol. 11 No. 10 · 2016 · Inggris · PLOS Scopus

Introduction: In a perspective of economic constraints the prioritizing of patients to IFN-free regimens is mainly based on the determination of liver stiffness by transient elastography (TE). Being a continuous variable the interpretation of TE results requires the identification of cut-off…

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Limited Utility of ITPA Deficiency to Predict Early Anemia in HCV Patients with Advanced Fibrosis Receiving Telaprevir

Alessio Aghemo; Eleonora Grassi; Maria Grazia Rumi dkk.

PLoS ONE, Vol. 9 No. 4 · 2014 · Inggris · PLOS Scopus

Background: Severe anemia is a common side effect of Pegylated Interferon + Ribavirin (PR) and Telaprevir (TVR) in hepatitis C virus (HCV) genotype 1 patients with advanced fibrosis or cirrhosis (F3–F4). Inosine triphosphatase (ITPA) genetic variants are associated with RBV- induced anemia and dose…

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Serological Tests Do Not Predict Residual Fibrosis in Hepatitis C Cirrhotics with a Sustained Virological Response to Interferon

Roberta D’Ambrosio; Elisabetta Degasperi; Alessio Aghemo dkk.

PLOS ONE, Vol. 11 No. 6 · 2016 · Inggris · PLOS Scopus

Background and Aim: Liver biopsy (LB) has lost popularity to stage liver fibrosis in the era of highly effective anti-hepatitis C virus (HCV) therapy, yet diagnosis of persistent cirrhosis may have important implications following HCV eradication. As performance of serological non-invasive tests…

Interaction between PNPLA3 I148M Variant and Age at Infection in Determining Fibrosis Progression in Chronic Hepatitis C

Stella De Nicola; Paola Dongiovanni; Alessio Aghemo dkk.

PLoS ONE, Vol. 9 No. 8 · 2014 · Inggris · PLOS Scopus

Background and Aims: The PNPLA3 I148M sequence variant favors hepatic lipid accumulation and confers susceptibility to hepatic fibrosis and hepatocellular carcinoma. The aim of this study was to estimate the effect size of homozygosity for the PNPLA3 I148M variant (148M/M) on the fibrosis…

PNPLA3 I148M Polymorphism, Clinical Presentation, and Survival in Patients with Hepatocellular Carcinoma

Luca Valenti; Benedetta Maria Motta; Giorgio Soardo dkk.

PLoS ONE, Vol. 8 No. 10 · 2013 · Inggris · PLOS Scopus

Background & Aims: Aim of this study was to evaluate whether the PNPLA3 I148M polymorphism, previously associated with hepatocellular carcinoma (HCC) risk, influences the clinical presentation of HCC and survival. Methods: we considered 460 consecutive HCC patients referred to tertiary care centers…

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity

Cristina Cheroni; Lorena Donnici; Alessio Aghemo dkk.

PLOS ONE, Vol. 10 No. 9 · 2015 · Inggris · PLOS Scopus

Hepatitis C virus (HCV) variants characterized by genomic deletions in the structural protein region have been sporadically detected in liver and serum of hepatitis C patients. These defective genomes are capable of autonomous RNA replication and are packaged into infectious viral particles in…

Failure of long-term lamivudine prophylaxis in patients with resolved hepatitis B infection undergoing chemotherapy and allogenic hematopoietic stem cell transplantation for hematological malignancies: two case reports

Glenda Grossi; Mauro Viganò; Floriana Facchetti dkk.

Haematologica, Vol. 102 No. 10 · 2017 · Inggris · DOAJ Scopus

Final Results of the Telaprevir Access Program: FibroScan Values Predict Safety and Efficacy in Hepatitis C Patients with Advanced Fibrosis or Cirrhosis

Antonia Lepida; Massimo Colombo; Inmaculada Fernandez dkk.

PLOS ONE, Vol. 10 No. 9 · 2015 · Inggris · PLOS Scopus

Background: Liver stiffness determined by transient elastography is correlated with hepatic fibrosis stage and has high accuracy for detecting severe fibrosis and cirrhosis in chronic hepatitis C patients. We evaluated the clinical value of baseline FibroScan values for the prediction of safety and…