14 hasil untuk "Maxime Meylan"

The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies

Florent Petitprez; Maxime Meylan; Aurélien de Reyniès dkk.

Frontiers in Immunology, Vol. 11 · 2020 · Inggris · DOAJ Scopus

Tumor cells constantly interact with their microenvironment, which comprises a variety of immune cells together with endothelial cells and fibroblasts. The composition of the tumor microenvironment (TME) has been shown to influence response to immune checkpoint blockade (ICB). ICB takes advantage…

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Tertiary lymphoid structures and B cells: An intratumoral immunity cycle

Wolf H. Fridman; Maxime Meylan; Guilhem Pupier dkk.

Immunity · 2023 · Inggris · OpenAlex Scopus

An Eight-Gene Hypoxia Signature Predicts Survival in Pancreatic Cancer and Is Associated With an Immunosuppressed Tumor Microenvironment

Raefa Abou Khouzam; Shyama Prasad Rao; Goutham Hassan Venkatesh dkk.

Frontiers in Immunology, Vol. 12 · 2021 · Inggris · DOAJ Scopus

Intratumoral hypoxia is a widely established element of the pancreatic tumor microenvironment (TME) promoting immune escape, tumor invasion, and progression, while contributing to treatment resistance and poor survival. Despite this critical role, hypoxia is underrepresented in molecular signatures…

The murine Microenvironment Cell Population counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations in murine samples using gene expression

Florent Petitprez; Sacha Levy; Cheng-Ming Sun dkk.

Genome Medicine, Vol. 12 No. 1 · 2020 · Inggris · DOAJ Scopus

Abstract Quantifying tissue-infiltrating immune and stromal cells provides clinically relevant information for various diseases. While numerous methods can quantify immune or stromal cells in human tissue samples from transcriptomic data, few are available for mouse studies. We introduce murine…

Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer

Maxime Meylan; Florent Petitprez; Étienne Becht dkk.

Immunity · 2022 · Inggris · OpenAlex Scopus

Tumor stage-driven disruption of NK cell maturation in human and murine tumors

Jules Russick; Carine Torset; Dan Sun dkk.

iScience, Vol. 27 No. 11 · 2024 · Inggris · DOAJ Scopus

Summary: Natural killer (NK) cells play a pivotal role against cancer, both by direct killing of malignant cells and by promoting adaptive immune response though cytokine and chemokine secretion. In the lung tumor microenvironment (TME), NK cells are scarce and dysfunctional. By conducting…

Comprehensive analyses of immune tumor microenvironment in papillary renal cell carcinoma

Laurence Albiges; Bernard Escudier; Gwenaelle Gravis dkk.

Journal for ImmunoTherapy of Cancer, Vol. 11 No. 11 · 2023 · Inggris · DOAJ Scopus

Background Papillary renal cell carcinoma (pRCC) is the most common non-clear cell RCC, and associated with poor outcomes in the metastatic setting. In this study, we aimed to comprehensively evaluate the immune tumor microenvironment (TME), largely unknown, of patients with metastatic pRCC and…

Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions

Diane Damotte; Laurence Zitvogel; Marco Alifano dkk.

Journal for ImmunoTherapy of Cancer, Vol. 8 No. 2 · 2020 · Inggris · DOAJ Scopus

Background Natural killer (NK) cells play a crucial role in tumor immunosurveillance through their cytotoxic effector functions and their capacity to interact with other immune cells to build a coordinated antitumor immune response. Emerging data reveal NK cell dysfunction within the tumor…

Baseline circulating unswitched memory B cells and B-cell related soluble factors are associated with overall survival in patients with clear cell renal cell carcinoma treated with nivolumab within the NIVOREN GETUG-AFU 26 study

Laurence Albiges; Bernard Escudier; Catherine Sautes-Fridman dkk.

Journal for ImmunoTherapy of Cancer, Vol. 10 No. 5 · 2022 · Inggris · DOAJ Scopus

Background The phase II NIVOREN GETUG-AFU 26 study reported safety and efficacy of nivolumab in patients with metastatic clear cell renal cell carcinoma (m-ccRCC) in a ‘real-world setting’. We conducted a translational-research program to determine whether specific circulating immune-cell…

Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity

Marie-Agnès Dragon-Durey; Xiaoyi Chen; Amos Kirilovsky dkk.

PLOS ONE, Vol. 16 No. 5 · 2021 · Inggris · PLOS Scopus

To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs’ functions according to body mass index…

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Immune Signature Linked to COVID-19 Severity: A SARS-Score for Personalized Medicine

Jules Russick; Pierre-Emmanuel Foy; Nathalie Josseaume dkk.

Frontiers in Immunology, Vol. 12 · 2021 · Inggris · DOAJ Scopus

SARS-CoV-2 infection leads to a highly variable clinical evolution, ranging from asymptomatic to severe disease with acute respiratory distress syndrome, requiring intensive care units (ICU) admission. The optimal management of hospitalized patients has become a worldwide concern and identification…

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Rodrigo Dienstmann; Eduardo García‐Galea; Alice O'Farrell dkk.

Molecular Oncology, Vol. 20 No. 7 · 2026 · Inggris · DOAJ Scopus

To explore the immune microenvironment of RAS‐mutated (RASmt) microsatellite stable (MSS) colon cancer (CC), we retrospectively performed whole exome sequencing, RNA sequencing, and robust digital pathology analyses and studied immune markers in a cohort of 161 patients treated with…