5 hasil untuk "Michael Screen"
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Artikel Jurnal Teks lengkap
Molecular Basis of Differential Sensitivity of Myeloma Cells to Clinically Relevant Bolus Treatment with Bortezomib
The proteasome inhibitor bortezomib (Velcade) is prescribed for the treatment of multiple myeloma. Clinically achievable concentrations of bortezomib cause less than 85% inhibition of the chymotrypsin-like activity of the proteasome, but little attention has been paid as to whether in vitro studies…
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Artikel Jurnal
RNA helicase EIF4A1-mediated translation is essential for the GC response
Conditional mouse knock-out models show that EIF4A1, but not its cofactors EIF4B or EIF4H, is essential in B cells for their development, the GC response, and increased translation after activation. EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell…
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Artikel Jurnal
An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells
Abstract During B cell maturation, transitional and mature B cells acquire cell-intrinsic features that determine their ability to exit quiescence and mount effective immune responses. Here we use label-free proteomics to quantify the proteome of B cell subsets from the mouse spleen and map the…
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Artikel Jurnal
A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells
To identify roles of RNA binding proteins (RBPs) in the differentiation or survival of antibody secreting plasma cells we performed a CRISPR/Cas9 knockout screen of 1213 mouse RBPs for their ability to affect proliferation and/or survival, and the abundance of differentiated CD138 + cells in vitro…