64 hasil untuk "Muhammad Moazzam"
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Artikel Jurnal
A Review on Flavonoids as a Potential Biomolecule for Inhibiting the Effect of Head and Neck Cancer
Context: Cancer is one of the most significant, complex, and long-term diseases, characterized by uncontrolled cell multiplication, affecting millions of people around the globe. Developed countries are considered to experience higher incidence and mortality rates due to cancer. Cancer affects…
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Synthesis and DNA binding studies of novel triazine-isatin hybrids: experimental and computational insights
DNA binding is a crucial determinant in developing novel anticancer agents, as it plays a key role in the mechanism of action for many chemotherapeutic drugs. In this study, a series of novel s-triazine-isatin hybrids (7a–f) was synthesized, and their binding interactions with salmon sperm DNA…
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SOME OBSERVATIONS ON THE SWARM OF PEGEA CONFOEDERATA(TUNICATA: SALPIDAE) IN MIANIHOR, BALOCHISTAN, PAKISTAN
A swarm of salpid Pegea confoederata was observed in the Miani Hor lagoon on 27 February 2017. The swarm which was consisted predominantly of pelagic tunicate was found to be widely distributed within the lagoon whereas the swarm was not observed outside the Miani Hor except near the entrance. In…
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Recent biological applications of heterocyclic hybrids containing s-triazine scaffold
s-Triazine possesses an auspicious status in the field of drug discovery and development owing to its presence in many naturally occurring compounds as well as commercially available drugs like enasidenib, gedatolisib, bimiralisib, atrazine, indaziflam, and triaziflam. Easy, cost-effective, and…
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Synthesis and Anti-inflammatory Activity of New N-Acyl-2-pyrazolines Bearing Homologous Alkyloxy Side Chains
A series of new pyrazoline derivatives (1b-8c) equipped with N-acyl arms and homologous alkyloxy side chains were synthesized and characterized on the basis of spectroscopic data and microanalysis. All the synthesized compounds were screened for their in-vitro anti-inflammatory activity to examine…
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RANGE EXTENSION OF ADEN TORPEDO (TORPEDO ADENENSIS) INTO PAKISTAN COAST (NORTHERN ARABIAN SEA)
Torpedo adenensis Carvalho, Stehmann and Manilo 2002 (Aden torpedo) was considered to an endemic species in the Gulf of Aden, however, a male (530 mm TL) was collected from Karachi Fish Harbour on 28 November, 2013 which extends it distribution range to coast of Pakistan (Northern Arabian Sea). A…
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ADDITIONAL REPORT ON ARMSTRONGS’ SPIDER CRAB, ENCEPHALOIDES ARMSTRONGI WOOD-MASON & ALCOCK, 1891 (CRUSTACEA, DECAPODA, BRACHYURA, MAJIDAE) FROM PAKISTANIS WATERS
Encephaloides is a monotypic genus with only one species, E. armstrongi, now known to be widely distributed in both the Arabian Sea and Bay of Bengal (Wood-Mason & Alcock, 1891; Creasy et al, 1997). Its placement into subfamily Pisinae (Family Majidae) has been discussed by Griffin and Tranter…
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Group B streptococcus sepsis in an infant presented with cellulitis of soft tissue of neck
We report a case of cellulitis of the soft tissue of the neck with group B streptococcus (GBS) sepsis in a 4-week-old baby boy presented with a 1-day history of fever, irritability and feed refusal. While in the hospital, a left-sided submandibular swelling extending to preauricular area started…
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Molecular duplexes featuring NH···N, CH···O and CH···π interactions in solid-state self-assembly of triazine-based compounds
Synthetic supramolecular structures constructed through the cooperative action of numerous non-covalent forces are highly desirable as models to unravel and understand the complexity of systems created in nature via self-assembly. Taking advantage of the low cost of 2,4,6-trichloro-1,3,5-triazine…
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Novel isatin–triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies
Thiosemicarbazones of isatin have been found to exhibit versatile bioactivities. In this study, two distinct types of isatin–triazole hybrids 3a and 3b were accessed via copper-catalyzed azide–alkyne cycloaddition reaction (CuAAC), together with their mono and bis-thiosemicarbazone derivatives 4a–h…
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Green and sustainable synthesis of chiral alcohols: the role of Daucus carota as a biocatalyst in organic chemistry
Chiral alcohols are essential intermediates in pharmaceuticals, agrochemicals, and advanced materials. Conventional asymmetric reduction of ketones relies on costly metal catalysts with significant environmental impact. Biocatalysis, particularly whole-cell systems, offers a sustainable…
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3-methylcrotonyl-CoA carboxylase deficiency in a child with developmental regression and delay: call for early diagnosis and multidisciplinary approach
3-methylcrotonyl-CoA carboxylase (3-MCC) deficiency (3-MCC-D) is an autosomal recessive disorder with a variable phenotype. Reduced 3-MCC enzyme activity results in impaired leucine metabolism causing, for example, metabolic acidosis, ketotic hypoglycaemia and carnitine deficiency. The spectrum of…
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Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside
The RNA interference (RNAi) pathway possesses immense potential in silencing any gene in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of specific genes. FDA Approval of siRNA therapeutics in recent years garnered a new hope in siRNA therapeutics. However, their…
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Synthesis, solid state self-assembly driven by antiparallel π⋯π stacking and {⋯H–C–C–F}(2) dimer synthons, and in vitro acetyl cholinesterase inhibition activity of phenoxy pendant isatins
A series of novel phenoxy pendant isatins PI1–12 have been synthesized in excellent yields by a simple nucleophilic substitution reaction involving isatins and 1-(2-bromoethoxy)-4-substituted benzenes, and characterized by their FT-IR, (1)H NMR, (13)C NMR and GC-MS data, and in the case of PI4 by…
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Isatin-3-thiosemicarbazone as Chromogenic Sensor for the Selective Detection of Fluoride Anion
In this study, we describe the anion recognition ability of isatin-3-thiosemicarbazone 2, which contains two different anion recognition units i.e. isatin NH and the thiourea moiety. Both have the ability to act as proton donors. Most importantly, a significant colour change of 2 was observed (from…
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Isatin as a simple, highly selective and sensitive colorimetric sensor for fluoride anion
Herein, we report the fluoride anion sensing properties of a commercially available and inexpensive organic compound, isatin, which is found to be a highly selective and sensitive sensor. In naked-eye experiments, by addition of fluoride anions, isatin shows a dramatic color change from pale yellow…
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Multi-step rainfall forecasting using deep learning approach
Rainfall prediction is immensely crucial in daily life routine as well as for water resource management, stochastic hydrology, rain run-off modeling and flood risk mitigation. Quantitative prediction of rainfall time series is extremely challenging as compared to other meteorological parameters due…
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Reasoning on Pore Terminology in 3D Bioprinting
Terminology is pivotal for facilitating clear communication and minimizing ambiguity, especially in specialized fields such as chemistry. In materials science, a subset of chemistry, the term “pore” is traditionally linked to the International Union of Pure and Applied Chemistry (IUPAC)…
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Intramolecular noncovalent C-bonding driven conformational preference in spiroisatin-based N-acyl hydrazones
Noncovalent carbon bonding (C-bonding), a recently explored σ-hole interaction, has primarily been characterized through X-ray structural and computational studies. Evidence of C-bonds in solution is scarce, especially in highly polar solvents like DMSO where solvation effects typically overshadow…