57 hasil untuk "Pascal Jabbour"
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Artikel Jurnal
Retinoblastoma in a 23-year-old adult treated with primary intra-arterial and intravitreal chemotherapy
Intra-arterial chemotherapy (IAC) continues to provide a globe-sparing alternative as primary treatment for retinoblastoma with few adverse events. While there is growing evidence to highlight the utility of IAC in children with retinoblastoma, adult cases treated with primary IAC have not…
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Artikel Jurnal Teks lengkap
The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions
Inflammation is increasingly being understood to be a key component to the pathophysiology of cerebrovascular lesions. Ferumoxytol, an iron oxide nanoparticle coated by a carbohydrate shell, has been used in MRI studies as an inflammatory marker because it is cleared by macrophages…
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Artikel Jurnal
Minimal exposure intra-arterial chemotherapy for children with retinoblastoma and 13q syndrome
Two infants with retinoblastoma and 13q syndrome with multiorgan system anomalies were treated with targeted intra-arterial chemotherapy (IAC) using one-to-three cycles of melphalan 5 mg to avoid systemic chemotherapeutic side effects. Both patients showed good response, with tumor control and no…
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Artikel Jurnal
Abstract 1122‐000231: A Review of Effect of Ticagrelor on Platelet Inhibition in Clopidogrel Non‐Responders Undergoing Neuroendovascular Procedure
Introduction: Neuroendovascular procedures are becoming more routine in the treatment of intracranial conditions such as aneurysms, arterial stenosis, and ischemic stroke. These patients are frequently treated with antiplatelet agents prior to the procedure to prevent thrombotic complications. The…
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Artikel Jurnal
The middle meningeal artery as an alternative route for intra-arterial chemotherapy
Retinoblastoma is a deadly eye cancer in children, leading to death in 50%–70% of children in undeveloped nations. Unfortunately, this aggressive tumor is the most common intraocular malignancy worldwide. For the last 2 decades, intravenous (IV) chemotherapy has been the mainstay of treatment for…
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Artikel Jurnal
Management of retinoblastoma in older children (>5 years) using intra-arterial chemotherapy: Comparison of outcomes to prechemotherapy and intravenous chemotherapy eras
Purpose: Intra-arterial chemotherapy (IAC) has emerged as an effective treatment for retinoblastoma (RB) however, little information exists regarding its use in older patients (>5 years). In the present study, we evaluate the use of IAC (2008–2018) for RB in older patients and compare the outcomes…
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Artikel Jurnal
Sex Differential in 15‐Hydroxyprostaglandin Dehydrogenase Levels in the Lumen of Human Intracranial Aneurysms
BackgroundAspirin is a promising medical therapy for the prevention of intracranial aneurysm (IA) rupture. Recently, we found that men have a better response to aspirin than women. The purpose of this study was to determine whether a sex differential exists in the level of 15‐hydroxyprostaglandin…
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Artikel Jurnal
Management of Head and Neck Pseudoaneurysms: A Review of 33 Consecutive Cases
Background. Endosaccular coiling, vessel occlusion, stenting, stent-assisted coiling, and flow diversion are all endovascular treatment options for pseudoaneurysms (PAs) of the head and neck. We explore different clinical situations in which these were selected for PA management at a single…
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Artikel Jurnal
Failure of the Pipeline Embolization Device in Posterior Communicating Artery Aneurysms Associated with a Fetal Posterior Cerebral Artery
The pipeline embolization device has emerged as an important endovascular option. This is in part due to safety, efficacy, and possibly the ability to shorten the operative time considerably. With this new technology, some limitations are emerging as experience accumulates. We report three cases of…
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Artikel Jurnal
Endovascular Intervention for Acute Ischemic Stroke in Light of Recent Trials
Three recently published trials, MR RESCUE, IMS III, and SYNTHESIS Expansion, evaluating the efficacy and safety of endovascular treatment of acute ischemic stroke have generated concerns about the future of endovascular approach. However, the tremendous evolution that imaging and endovascular…
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Artikel Jurnal
Acute Neurological Care in the COVID-19 Era: The Pandemic Health System REsilience PROGRAM (REPROGRAM) Consortium Pathway
The management of acute neurological conditions, particularly acute ischemic stroke, in the context of Coronavirus disease 2019 (COVID-19), is of importance, considering the risk of infection to the healthcare workers and patients and emerging evidence of the neuroinvasive potential of the virus…
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Artikel Jurnal
Abstract 274: Mechanical Thrombectomy for Ischemic Stroke in Elderly Population
Introduction Stroke is a leading cause of mortality and morbidity worldwide and the risk increases with age. Mechanical thrombectomy (MT) in eligible patients is proven to improve outcomes and is ow standard of care for acute ischemic stroke. Clinical trials evaluating MT often exclude patients…
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Artikel Jurnal
Abstract 1122‐000226: Collaborative Stroke Pathway for In‐Patient Implantation of Long‐Term Cardiac Rhythm Monitors for Atrial Fibrillation Detection
Introduction: Atrial fibrillation (AF) is a recognized risk factor of ischemic stroke and AF‐related stroke is twice more likely to prove fatal. Long‐term cardiac rhythm monitoring has greater diagnostic yield compared to conventional monitoring in detecting AF. Utility of implantable loop recorder…
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Artikel Jurnal
The impact of mechanical thrombectomy on the blood–brain barrier in patients with acute ischemic stroke: A non-contrast MR imaging study using DP-pCASL and NODDI
Background and purpose: While mechanical thrombectomy (MT) achieves restoration of cerebral blood flow to the area at risk in patients with acute ischemic stroke (AIS), the influx of blood flow may exacerbate the blood–brain barrier (BBB) disruption and extravasation across the BBB, and it…
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Artikel Jurnal
Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms
Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling (SAC) and flow diverters. Glycoprotein IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy (DAPT) are required to prevent thromboembolic complications afterwards. We sought to…
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Artikel Jurnal
Redefining Onyx HD 500 in the Flow Diversion Era
We report the largest US case series results using Onyx HD-500 (EV3), a new liquid embolic agent, in the successful treatment of 21 patients with wide-neck intracranial aneurysms (mean size 4.5 mm), which are at increased risk of incomplete occlusion or recanalization with standard endovascular…
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Artikel Jurnal
Plasma Soluble Human Elastin Fragments as an Intra‐Aneurysmal Localized Biomarker for Ruptured Intracranial Aneurysm
Background Fragmentation of the tunica media is a hallmark of intracranial aneurysm formation, often leading to aneurysmal progression and subsequent rupture. The objective of this study is to determine the plasma level of elastin fragments in the lumen of ruptured versus unruptured human…