157 hasil untuk "Sandhya, S."
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Preprint Teks lengkap
Resonance flourescence in atomic coherent systems: spectral features
We study resonance flourescence in a four level ladder system and illustrate some novel features due to quantum interference and atomic coherence effects. We find that under three photon resonant conditions, in some region of the parameter space of the rabi frequencies $Ω_1,Ω_2,Ω_3$, emission is…
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Artikel Jurnal
Receptor Guanylyl Cyclase C and Cyclic GMP in Health and Disease: Perspectives and Therapeutic Opportunities
Receptor Guanylyl Cyclase C (GC-C) was initially characterized as an important regulator of intestinal fluid and ion homeostasis. Recent findings demonstrate that GC-C is also causally linked to intestinal inflammation, dysbiosis, and tumorigenesis. These advances have been fueled in part by…
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Artikel Jurnal Teks lengkap
Impaired Intestinal Sodium Transport in Inflammatory Bowel Disease: From the Passenger to the Driver's SeatSummary
Although impaired intestinal sodium transport has been described for decades as a ubiquitous feature of inflammatory bowel disease (IBD), whether and how it plays a pivotal role in the ailment has remained uncertain. Our identification of dominant mutations in receptor guanylyl cyclase 2C as a…
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Artikel Jurnal
On some Separation Axioms in Soft Lattice Topological Spaces
In the realm of topology, various constraints are frequently imposed on the types of topological spaces under examination and these constraints are defined by what are known as separation axioms. Also, the separation axioms can be seen as additional conditions that may be incorporated into the…
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Artikel Jurnal
ENSURING EQUITY IN AN UNEQUAL WORLD: FRAMEWORK FOR AN ALTERNATE DEVELOPMENT PARADIGM
The objective of the study is to analyze the multifaceted crises affecting global development, such as the Covid-19 pandemic, climate change, and increasing inequality. It critiques the traditional gross domestic product (GDP) driven development model and suggests an alternative framework based on…
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Artikel Jurnal Teks lengkap
The pseudokinase domain in receptor guanylyl cyclases
Cyclic GMP is produced by enzymes called guanylyl cyclases, of which the membrane-associated forms contain an intracellular pseudokinase domain that allosterically regulates the C-terminal guanylyl cyclase domain. Ligand binding to the extracellular domain of these single transmembrane-spanning…
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Artikel Jurnal Teks lengkap
Intramacrophage ROS Primes the Innate Immune System via JAK/STAT and Toll Activation
Tissue injury is one of the most severe environmental perturbations for a living organism. When damage occurs in adult Drosophila, there is a local response of the injured tissue and a coordinated action across different tissues to help the organism overcome the deleterious effect of an injury. We…
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Artikel Jurnal Teks lengkap
Gut reactions and gut instincts: regulation of intestinal homeostasis by receptor guanylyl cyclase C (GC-C)
The important role that the gut plays in directing and modulating the well-being of the entire organism cannot be underestimated. We are beginning to dissect molecular players that are intrinsic to the functioning of the epithelial cells of the gut, which, in turn, control the responses of various…
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Artikel Jurnal
On the Cardinality and Power Set of Fuzzy Sets and Multiple Sets
A multiple set is a generalized version of a fuzzy set that deals with the uncertainty of an object along with its multiplicity. This work is a comparative analysis of the fundamental conclusions based on the cardinality of the classical set and fuzzy set. Several classical results based on fuzzy…
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Artikel Jurnal
UV Signatures of Magnetar Formation and Their Crucial Role for GW Detection
The emission from shock breakouts (SBOs) represents the earliest electromagnetic (EM) signal emitted by cataclysmic events involving the formation or the merger of neutron stars (NSs). As such, SBOs carry unique information on the structure of their progenitors and on the explosion energy. The…
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Artikel Jurnal Teks lengkap
Mechanisms Stimulating Muscle Wasting in Chronic Kidney Disease: The Roles of the Ubiquitin-Proteasome System and Myostatin
Catabolic conditions including chronic kidney disease (CKD), cancer, and diabetes cause muscle atrophy. The loss of muscle mass worsens the burden of disease because it is associated with increased morbidity and mortality. To avoid these problems or to develop treatment strategies, the mechanisms…
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Artikel Jurnal Teks lengkap
Distinct Allostery Induced in the Cyclic GMP-binding, Cyclic GMP-specific Phosphodiesterase (PDE5) by Cyclic GMP, Sildenafil, and Metal Ions
The activity of many proteins orchestrating different biological processes is regulated by allostery, where ligand binding at one site alters the function of another site. Allosteric changes can be brought about by either a change in the dynamics of a protein, or alteration in its mean structure…
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Artikel Jurnal Teks lengkap
Parathyroid hormone stimulates adipose tissue browning: a pathway to muscle wasting
PURPOSE: studying organ-to-organ communications (i.e., crosstalk) uncovers mechanisms regulating metabolism in several tissues. What is missing is identification of mediators of different catabolic conditions contributing to losses of adipose and muscle tissues. Identifying mediators involved in…
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Artikel Jurnal Teks lengkap
The Non-catalytic “Cap Domain” of a Mycobacterial Metallophosphoesterase Regulates Its Expression and Localization in the Cell
Despite highly conserved core catalytic domains, members of the metallophosphoesterase (MPE) superfamily perform diverse and crucial functions ranging from nucleotide and nucleic acid metabolism to phospholipid hydrolysis. Unique structural elements outside of the catalytic core called “cap…
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Artikel Jurnal Teks lengkap
Pharmacognostical Standardization of Tephrosia purpurea Pers Root
Wild Indigo or Purple Tephrosia or fish poison occurs throughout the Indian subcontinent. It is widely used in the treatment of inflammation, diabetes, rheumatism, asthma, diarrhoea and many other ailments. But so far the pharmacognostic standardization has not been reported for its proper…