12 results for "Simone Altmann"

dl-β-Aminobutyric Acid–Induced Resistance of Potato Against Phytophthora infestans Requires Salicylic Acid but Not Oxylipins

Lennart Eschen-Lippold; Simone Altmann; Sabine Rosahl

Molecular Plant-Microbe Interactions, Vol. 23 No. 5 · 2010 · English · DOAJ

Inducing systemic resistance responses in crop plants is a promising alternative way of disease management. To understand the underlying signaling events leading to induced resistance, functional analyses of plants defective in defined signaling pathway steps are required. We used potato, one of…

Gradual and Acute Temperature Rise Induces Crossing Endocrine, Metabolic, and Immunological Pathways in Maraena Whitefish (Coregonus maraena)

Alexander Rebl; Marieke Verleih; Mareen Nipkow et al.

Frontiers in Genetics, Vol. 9 · 2018 · English · DOAJ Scopus

The complex and still poorly understood nature of thermoregulation in various fish species complicates the determination of the physiological status on the basis of diagnostic marker genes and indicative molecular pathways. The present study aimed to compare the physiological impacts of both…

Acoziborole resistance associated mutations in Trypanosoma brucei CPSF3

Melanie Ridgway; Markéta Novotná; Cesar Mendoza-Martinez et al.

PLOS Pathogens, Vol. 22 No. 3 · 2026 · English · PLOS Scopus

Acoziborole is a safe, single dose, oral therapy, for treatment of both early and late-stage sleeping sickness, a deadly disease caused by African trypanosomes. Other benzoxaboroles show efficacy against other trypanosomatids, apicomplexans, fungi, bacteria, and viruses. Acoziborole targets the…

Also available at: DOAJ

Salicylic Acid Is Important for Basal Defense of Solanum tuberosum Against Phytophthora infestans

Vincentius A. Halim; Lennart Eschen-Lippold; Simone Altmann et al.

Molecular Plant-Microbe Interactions, Vol. 20 No. 11 · 2007 · English · DOAJ

The importance of the signaling compound salicylic acid for basal defense of potato (Solanum tuberosum L. cv. Désirée) against Phytophthora infestans, the causal agent of late blight disease, was assessed using transgenic NahG potato plants which are unable to accumulate salicylic acid. Although…

FMOPhore for hotspot identification and efficient fragment-to-lead growth strategies

Peter E. G. F. Ibrahim; Simone Altmann; Ulrich Zachariae et al.

Nature Communications, Vol. 17 No. 1 · 2026 · English · DOAJ Scopus

Abstract Fragment based drug design is like a chess game in that a good or a bad move can dramatically influence the outcome. In the design process, it is important to identify the key binding site residues (hotspots) that can have a substantial impact on ligand potency and efficiency. Here, we…

Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis

Thomas D. Friedrich; Vicky Oberkofler; Inês Trindade et al.

Nature Communications · 2021 · English · OpenAlex Scopus

Adaptive plasticity in stress responses is a key element of plant survival strategies. For instance, moderate heat stress (HS) primes a plant to acquire thermotolerance, which allows subsequent survival of more severe HS conditions. Acquired thermotolerance is actively maintained over several days…

Also available at: DOAJ

Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling

Krzysztof Brzezinka; Simone Altmann; Hjördis Czesnick et al.

eLife, Vol. 5 · 2016 · English · DOAJ

Plants as sessile organisms can adapt to environmental stress to mitigate its adverse effects. As part of such adaptation they maintain an active memory of heat stress for several days that promotes a more efficient response to recurring stress. We show that this heat stress memory requires the…

Multi-omics approaches define novel aphid effector candidates associated with virulence and avirulence phenotypes

Peter Thorpe; Simone Altmann; Rosa Lopez-Cobollo et al.

BMC Genomics, Vol. 25 No. 1 · 2024 · English · DOAJ Scopus

Abstract Background Compatibility between plant parasites and their hosts is genetically determined {Citation}both interacting organisms. For example, plants may carry resistance (R) genes or deploy chemical defences. Aphid saliva contains many proteins that are secreted into host tissues. Subsets…

Decoding efficacy and resistance space at a drug binding site

Simone Altmann; Cesar Mendoza-Martinez; Melanie Ridgway et al.

Nature Communications, Vol. 17 No. 1 · 2026 · English · DOAJ Scopus

Abstract Assessing and understanding the impacts of all possible mutations at a drug binding site remain challenging. Here we use multiplex oligo targeting for mutational profiling, and computational modelling, to decode efficacy and resistance space at the otherwise native binding site for an…

A Novel Chitinase-Like Family of Candidate Effectors Unique to Aphids

Rosa Lopez-Cobollo; Simone Altmann; Peter Thorpe et al.

Molecular Plant-Microbe Interactions, Vol. 39 No. 1 · 2026 · English · DOAJ

Molecular interactions between aphids and plants include delivery of salivary effector proteins into host cells, acting as virulence factors to suppress host immunity or as avirulence functions triggering immune activation. However, understanding of virulence and avirulence mechanisms in…