10 hasil untuk "Tianshu Yu"
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Artikel Jurnal
Substitutability of urban sustainability assessment indicators: A semantic similarity analysis
Abstarct: Urban sustainability assessment is an effective method for objectively presenting the current state of sustainable urban development and diagnosing sustainability-related issues. As the global community intensifies its efforts to implement the sustainable development goals (SDGs), the…
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Artikel Jurnal
Advances in strategies to improve the immunotherapeutic efficacy of chimeric antigen receptor-T cell therapy for lymphoma
Chimeric antigen receptor-T (CAR-T) cell therapy is a precise immunotherapy for lymphoma. However, its long-term efficacy faces many challenges related to tumor cell heterogeneity, interference from immunosuppressive microenvironments, CAR-T cell exhaustion, and unmanageable adverse events. Diverse…
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Artikel Jurnal
CoxFormer enables spatial omics inference with multimodal generative modeling
Abstract Gene co-expression maps transcriptome-wide gene-gene relationships, yet high-quality estimates cover less than half the genome. Meanwhile, spatial omics either profiles restricted in situ panels or lacks cellular resolution. Extending co-expression transcriptome-wide could overcome these…
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Artikel Jurnal
Abnormal expansion of peripheral helper T cells in primary immune thrombocytopenia
Peripheral helper T (Tph) cells, a distinct T-cell subset defined as CD4+PD-1hiCXCR5− phenotypically, are increasingly recognized as key drivers of antibody-mediated autoimmunity; however, their role in primary immune thrombocytopenia (ITP) remains poorly defined. In this study, we evaluated…
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Germline variant spectrum of hereditary cancer susceptibility genes in a Chinese cohort
Abstract Background Hereditary cancers, caused by germline pathogenic variants in cancer susceptibility genes, account for 5%∼10% of malignancies globally. However, their prevalence and genetic spectrum in the Chinese population remain poorly characterized. This study aimed to investigate germline…
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Artikel Jurnal
Circular RNA CDR1as/ciRS-7– a novel biomarker in solid tumors
IntroductionCircular RNA CDR1as/ciRS-7 has been reported to function as an oncogenic regulator in various cancers. However, the prognostic value of CDR1as/ciRS-7 expression in solid tumors remains unclear. Herein, we conducted an updated meta-analysis to investigate the association between…
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Artikel Jurnal
Enhancing regulatory T-cell function via inhibition of high mobility group box 1 protein signaling in immune thrombocytopenia
Primary immune thrombocytopenia (ITP) is the most common acquired autoimmune bleeding disorder. Abnormally increased levels of High Mobility Group Box 1 (HMGB1) protein associate with thrombocytopenia and therapeutic outcome in ITP. Previous studies proposed that a natural inhibitor of HMGB1…
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Artikel Jurnal
Towards global reaction feasibility and robustness prediction with high throughput data and bayesian deep learning
Abstract Predicting organic reaction feasibility and robustness against environmental factors is challenging. We address this issue by integrating high throughput experimentation (HTE) and Bayesian deep learning. Diverging from existing HTE studies focused on niche chemical spaces, in this work…
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Artikel Jurnal
Low-Dose Decitabine Inhibits Cytotoxic T Lymphocytes-Mediated Platelet Destruction via Modulating PD-1 Methylation in Immune Thrombocytopenia
Cytotoxic T lymphocytes (CTLs)-mediated platelet destruction plays an important role in the pathogenesis of primary immune thrombocytopenia (ITP). The programmed cell death protein 1 (PD-1) signaling can turn off autoreactive T cells and induce peripheral tolerance. Herein, we found that the…