23 hasil untuk "Tom Dudding"
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Artikel Jurnal
The consequence of the closure of primary care dental services on secondary care during the COVID-19 pandemic – A national outlook
Background: After the global pandemic of COVID-19 in March 2020, restrictions were implemented on all aspects of routine dental-care with a primary focus to urgent care only. Aim: To investigate the impact on secondary care medical facilities and Emergency Department (ED) admissions for the…
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Artikel Jurnal
Age 23 years + oral health questionnaire in Avon Longitudinal Study of Parents and Children. [version 2; referees: 2 approved]
Oral health data in large longitudinal cohort studies is rarely collected at multiple time-points. This type of data is important for assessing oral health trajectories and their determinants. This data resource includes self-report questionnaire data on up to 4,222 young adults at approximately 23…
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Artikel Jurnal
An observational analysis of risk factors associated with symptomatic third molar teeth [version 1; peer review: 2 approved, 1 approved with reservations]
Background: Third molar teeth (wisdom teeth) are a common cause of pain and infection in young adults. The study aimed to describe the prevalence of symptomatic third molar teeth and identify factors which predispose to third molar symptoms in a birth cohort. Methods: An observational study was…
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Artikel Jurnal
An observational analysis of risk factors associated with symptomatic third molar teeth [version 2; peer review: 2 approved]
Background: Third molar teeth (wisdom teeth) are a common cause of pain and infection in young adults. The study aimed to describe the prevalence of symptomatic third molar teeth and identify factors which predispose to third molar symptoms in a birth cohort. Methods: An observational study was…
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Artikel Jurnal Teks lengkap
Re-Examining the Association between Vitamin D and Childhood Caries
Background: Previous studies have reported an inverse association between vitamin D and childhood dental caries, but whether this is causal is unclear. Objective: To determine the causal effect of circulating 25-hydroxyvitamin D concentration on dental caries experience, early caries onset and the…
Juga tersedia di: DOAJ
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Artikel Jurnal Teks lengkap
Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci
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Artikel Jurnal
Examining the causal association between 25-hydroxyvitamin D and caries in children and adults: a two-sample Mendelian randomization approach [version 2; peer review: 2 approved]
Background: Prior observational studies have reported that higher levels of vitamin D are associated with decreased caries risk in children. However, these studies are prone to bias and confounding so do not provide causal inference. Genetic variants associated with a risk factor of interest can be…
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Artikel Jurnal
Long-term treatment outcomes with zygomatic implants: a systematic review and meta-analysis
Abstract Purpose The purpose of this study was to perform a systematic review with meta-analysis on the long-term survival rates of zygomatic implants (ZI). ZI success, prostheses survival and success, sinus pathology and patient reported outcomes were also investigated. Methods Preferred Reporting…
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Artikel Jurnal
Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization
A recent World Health Organization report states that at least 40% of all cancer cases may be preventable, with smoking, alcohol consumption, and obesity identified as three of the most important modifiable lifestyle factors. Given the significant decline in smoking rates, particularly within…
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Artikel Jurnal Teks lengkap
A clinical observational analysis of aerosol emissions from dental procedures
Aerosol generating procedures (AGPs) are defined as any procedure releasing airborne particles
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Artikel Jurnal
Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
Population structure can bias the results of genetic and epidemiological analysis. Here, Haworth et al. report that fine-scale structure is detectable in apparently homogeneous samples such as ALSPAC when measured very precisely, and remains detectable in UK Biobank despite conventional approaches…
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Artikel Jurnal
Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study
Background: Adiposity has been associated with an increased risk of head and neck cancer (HNC). Although body mass index (BMI) has been inversely associated with HNC risk among smokers, this is likely due to confounding. Previous Mendelian randomization (MR) studies could not fully discount…
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Artikel Jurnal
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer
Alcohol and smoking are both associated with oral/oropharyngeal cancer risk, but independent effects are unclear given their relatedness. Here, the authors use multivariable Mendelian randomization to show that both alcohol and smoking are independently causal for oral/oropharyngeal cancer.
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Artikel Jurnal
Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci
Oral ulcerations are sores of the mucous membrane of the mouth and highly prevalent in the population. Here, in a genome-wide association study, the authors identify 97 loci associated with mouth ulcers highlighting genes involved in T cell-mediated immunity and TH1 responses.
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Artikel Jurnal Teks lengkap
Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study
Head and neck squamous cell carcinoma (HNSCC), which includes cancers of the oral cavity and oropharynx, is a cause of substantial global morbidity and mortality. Strategies to reduce disease burden include discovery of novel therapies and repurposing of existing drugs. Statins are commonly…
Juga tersedia di: DOAJ
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Artikel Jurnal
Investigating the effect of sexual behaviour on oropharyngeal cancer risk: a methodological assessment of Mendelian randomization
Abstract Background Human papilloma virus infection is known to influence oropharyngeal cancer (OPC) risk, likely via sexual transmission. However, sexual behaviour has been correlated with other risk factors including smoking and alcohol, meaning independent effects are difficult to establish. We…