9 hasil untuk "Yan Lin"
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Artikel Jurnal Teks lengkap
Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Sarcopenic obesity and diabetes are two increasing health problems worldwide, which both share many common risk factors, such as aging, and general obesity. The pathogenesis of sarcopenic obesity includes aging, physical inactivity, malnutrition, low-grade inflammation, insulin resistance, and…
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Artikel Jurnal
DEG 15, an update of the Database of Essential Genes that includes built-in analysis tools
Essential genes refer to genes that are required by an organism to survive under specific conditions. Studies of the minimal-gene-set for bacteria have elucidated fundamental cellular processes that sustain life. The past five years have seen a significant progress in identifying human essential…
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Artikel Jurnal Teks lengkap
Tunable CO2 electroreduction to ethanol and ethylene with controllable interfacial wettability
Abstract The mechanism of how interfacial wettability impacts the CO 2 electroreduction pathways to ethylene and ethanol remains unclear. This paper describes the design and realization of controllable equilibrium of kinetic-controlled *CO and *H via modifying alkanethiols with different alkyl…
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Artikel Jurnal Teks lengkap
STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway
Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA); however, the mechanism by which DNA damage drives OA is unclear. Previous research demonstrated that the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) participates in DNA damage…
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Artikel Jurnal Teks lengkap
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation
Oxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the mechanism that balances OXPHOS activity and intracellular oxygen availability remains elusive. Here, we report that mitochondrial protein lactylation is induced by intracellular hypoxia to constrain OXPHOS. We show that…
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Artikel Jurnal
Improvement in municipal wastewater treatment alters lake nitrogen to phosphorus ratios in populated regions
Large-scale and rapid improvement in wastewater treatment is common practice in developing countries, yet this influence on nutrient regimes in receiving waterbodies is rarely examined at broad spatial and temporal scales. Here, we present a study linking decadal nutrient monitoring data in lakes…
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Artikel Jurnal Teks lengkap
Immuno-genomic landscape of osteosarcoma
Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune checkpoint inhibitors (ICI). To gain insights into the immunogenic potential of these tumors, we conducted whole genome, RNA, and T-cell receptor sequencing, immunohistochemistry and reverse phase protein…
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Artikel Jurnal Teks lengkap
Structure-based classification predicts drug response in EGFR-mutant NSCLC
Abstract Epidermal growth factor receptor ( EGFR ) mutations typically occur in exons 18–21 and are established driver mutations in non-small cell lung cancer (NSCLC) 1–3 . Targeted therapies are approved for patients with ‘classical’ mutations and a small number of other mutations 4–6 . However…