9 results for "Yan-Lin He"

Sigma-1 Receptor Agonists Directly Inhibit Na V 1.2/1.4 Channels

Xiao-Fei Gao; Jin-Jing Yao; Yan-Lin He et al.

PLoS ONE, Vol. 7 No. 11 · 2012 · English · PLOS Scopus

(+)-SKF 10047 (N-allyl-normetazocine) is a prototypic and specific sigma-1 receptor agonist that has been used extensively to study the function of sigma-1 receptors. (+)-SKF 10047 inhibits K+, Na+ and Ca2+ channels via sigma-1 receptor activation. We found that (+)-SKF 10047 inhibited NaV1.2 and…

Also available at: DOAJ

Cyproheptadine Enhances the I K of Mouse Cortical Neurons through Sigma-1 Receptor-Mediated Intracellular Signal Pathway

Yan-Lin He; Chun-Lei Zhang; Xiao-Fei Gao et al.

PLoS ONE, Vol. 7 No. 7 · 2012 · English · PLOS Scopus

Cyproheptadine (CPH) is a histamine- and serotonin-receptor antagonist, and its effects are observed recently in the modulation of multiple intracellular signals. In this study, we used cortical neurons and HEK-293 cells transfected with Kv2.1 α-subunit to address whether CPH modify neural…

Also available at: DOAJ

Exposure to Extremely Low-Frequency Electromagnetic Fields Modulates Na + Currents in Rat Cerebellar Granule Cells through Increase of AA/PGE 2 and EP Receptor-Mediated cAMP/PKA Pathway

Yan-Lin He; Dong-Dong Liu; Yan-Jia Fang et al.

PLoS ONE, Vol. 8 No. 1 · 2013 · English · PLOS Scopus

Although the modulation of Ca2+ channel activity by extremely low-frequency electromagnetic fields (ELF-EMF) has been studied previously, few reports have addressed the effects of such fields on the activity of voltage-activated Na+ channels (Nav). Here, we investigated the effects of ELF-EMF on…

Also available at: DOAJ

Deformation Mechanism Investigation on Low Density 18Mn Steels under Different Solid Solution Treatments

Yong-Tao Huo; Yan-Lin He; Na-Qiong Zhu et al.

Metals, Vol. 11 No. 9 · 2021 · English · DOAJ Scopus

To meet the demand of the 10% weight reduction goal for automotive steel, the microstructure and mechanical properties of Fe-18Mn-Al-C steel with different carbon and aluminum contents were investigated under different solid solution treatments, and the deformation mechanisms of the experimental…

Strain-boosted hyperoxic graphene oxide efficiently loading and improving performances of microcystinase

Hong-Lin Liu; Cai Cheng; Ling-Zi Zuo et al.

iScience, Vol. 25 No. 7 · 2022 · English · DOAJ Scopus

Summary: Harmful Microcystis blooms (HMBs) and microcystins (MCs) that are produced by Microcystis seriously threaten water ecosystems and human health. This study demonstrates an eco-friendly strategy for simultaneous removal of MCs and HMBs by adopting unique hyperoxic graphene oxides (HGOs) as…

Potent Anti‐SARS‐CoV‐2 Efficacy of COVID‐19 Hyperimmune Globulin from Vaccine‐Immunized Plasma

Ding Yu; Yu‐Feng Li; Hong Liang et al.

Advanced Science, Vol. 9 No. 14 · 2022 · English · DOAJ Scopus

Abstract Coronavirus disease 2019 (COVID‐19) remains a global public health threat. Hence, more effective and specific antivirals are urgently needed. Here, COVID‐19 hyperimmune globulin (COVID‐HIG), a passive immunotherapy, is prepared from the plasma of healthy donors vaccinated with BBIBP‐CorV…