17 hasil untuk "Yu-Shih Lin"
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Toward Discovering New Anti-Cancer Agents Targeting Topoisomerase IIα: A Facile Screening Strategy Adaptable to High Throughput Platform
Topoisomerases are a family of vital enzymes capable of resolving topological problems in DNA during various genetic processes. Topoisomerase poisons, blocking reunion of cleaved DNA strands and stabilizing enzyme-mediated DNA cleavage complex, are clinically important antineoplastic and…
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Radiocarbon and Stable Carbon Isotope Constraints on the Propagation of Vent CO2 to Fluid in the Acidic Kueishantao Shallow Water Hydrothermal System
Abstract We report radiocarbon and stable carbon isotope measurements from vent gas (CO2(g)), dissolved inorganic carbon (DIC), and particulate organic carbon (POC), from two vents of the Kueishantao (KST) shallow‐water hydrothermal system, offshore northeast Taiwan. The purpose of this research is…
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The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase
An outbreak of coronavirus disease 2019 (COVID-19) occurred in Wuhan and it has rapidly spread to almost all parts of the world. For coronaviruses, RNA-dependent RNA polymerase (RdRp) is an important polymerase that catalyzes the replication of RNA from RNA template and is an attractive therapeutic…
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The contrast in suspended particle dynamics at surface and near bottom on the river-dominated northern South China Sea shelf in summer: implication on physics and biogeochemistry coupling
To understand the process-response relations among physical forcing and biogeochemical properties of suspended particles (SPs) in the river-dominated northern South China Sea shelf, a 5-day shipboard observation was conducted at a fixed location on the dispersal pathway of the Zhujiang (Pearl)…
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Physicochemical controls on ancient carbon assimilation into ecosystem biomass in shallow-water hydrothermal systems
Abstract Hydrothermal vents release substantial amounts of ancient carbon into the ocean, primarily as carbon dioxide, yet the extent to which this carbon is integrated into marine food webs remains poorly constrained. Here, we present a combination of bulk radiocarbon and stable carbon isotope…
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Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I
Danshen, also known as Salvia miltiorrhiza, is a medicinal herb used in traditional Chinese medicine. Its potential impact on endometrial cancer has not been thoroughly investigated. This study aimed to examine the effect of dihydroisotanshinone I (DT), a compound found in Danshen, on the viability…
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Cultivation-Independent and Cultivation-Dependent Analysis of Microbes in the Shallow-Sea Hydrothermal System Off Kueishantao Island, Taiwan: Unmasking Heterotrophic Bacterial Diversity and Functional Capacity
Shallow-sea hydrothermal systems experience continuous fluctuations of physicochemical conditions due to seawater influx which generates variable habitats, affecting the phylogenetic composition and metabolic potential of microbial communities. Until recently, studies of submarine hydrothermal…
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The effect and mechanism of astragalus polysaccharides on T cells and macrophages in inhibiting prostate cancer
Background: The impact and underlying mechanisms of astragalus polysaccharide (APS) on prostate cancer, particularly its role in immunomodulation, remain inadequately elucidated. Methods: This study employed the XTT assay for assessing proliferation in prostate cancer cells and macrophages. T cell…
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Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2
Outbreak of coronavirus disease 2019 occurred in Wuhan and has rapidly spread to almost all parts of world. GB-1, the herbal formula from Tian Shang Sheng Mu of Chiayi Puzi Peitian Temple, is used for the prophylaxis of SARS-CoV-2 in Taiwan. In this study, we investigated that the effect of GB-1…
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Astragalus Polysaccharides and Metformin May Have Synergistic Effects on the Apoptosis and Ferroptosis of Lung Adenocarcinoma A549 Cells
Astragalus polysaccharides (APSs), the compounds extracted from the common herb Astragalus membranaceus, have been extensively studied for their antitumor properties. In this study, we investigated the effect of APS on lung adenocarcinoma A549 cells. The effects of APS and the anti-diabetic drug…
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Microbial Community Composition and Functional Capacity in a Terrestrial Ferruginous, Sulfate-Depleted Mud Volcano
Terrestrial mud volcanoes (MVs) are an important natural source of methane emission. The role of microbial processes in methane cycling and organic transformation in such environments remains largely unexplored. In this study, we aim to uncover functional potentials and community assemblages across…
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Nasal irrigation with licorice extract (Glycyrrhiza glabra) in treating nasal polyps by reducing fibroblast differentiation and extracellular matrix production in TGF-β1-stimulated nasal polyp-derived fibroblasts by inhibiting the MAPK/ERK-1/2 pathway – an in vitro and in clinic study
Abstract Background To date, treating nasal polyps (NPs) is still a medical challenge. However, we have developed an innovative therapy using licorice extract (LE: Glycyrrhiza glabra) to treat rhinitis and sinusitis via nasal irrigation and have discovered that it significantly affects treatment of…
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Early diagenesis and carbon remineralization in young rift sediment of the Southern Okinawa Trough
With large topographic gradients, rifted basins serve as efficient traps for particulate matter from adjacent lands and the ocean surface. However, the fate of organic carbon in the sediment, mostly unaltered by the hydrothermal activities known to occur in young rifts, remains poorly understood…
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Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells
Danshen (salvia miltiorrhiza Bunge) is widely used in traditional Chinese medicine. However, it is definite clinical effort and mechanism on breast cancer is unclear. In our study, we used the real-world database to investigate in vivo protective effort of danshen in the breast cancer patients…
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The anti-SARS-CoV-2 effect and mechanism of Chiehyuan herbal oral protection solution
The Chiehyuan herbal oral protection solution (GB-2) is a herbal mixture commonly utilized in Taiwan for combating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as per traditional Chinese medicine practices. This study assessed the clinical impact of GB-2 through prospective clinical…
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Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway
Abstract Background Breast cancer is the most common cancer in women and affects 1.38 million women worldwide per year. Antiestrogens such as tamoxifen, a selective estrogen receptor (ER) modulator, are widely used in clinics to treat ER-positive breast tumors. However, remissions of breast cancer…