12 hasil untuk "Zebin Liao"

Effect of Nicotinamide Against Candida albicans

XinRui Xing; ZeBin Liao; Fei Tan dkk.

Frontiers in Microbiology, Vol. 10 · 2019 · Inggris · DOAJ Scopus

Nicotinamide (NAM) has a long history in clinical applications and can be safely used for treating various diseases. In recent years, NAM was found to exhibit antimicrobial activities, inhibiting the growth of Plasmodium falciparum, Mycobacterium tuberculosis, and human immunodeficiency virus…

Metabolomic profiling for the identification of potential biomarkers involved in a laboratory azole resistance in Candida albicans

Ling Li; ZeBin Liao; Yu Yang dkk.

PLOS ONE, Vol. 13 No. 2 · 2018 · Inggris · PLOS Scopus

Candida albicans, one of the most common fungal pathogens, is responsible for several yeast infections in human hosts, being resistant to classically used antifungal drugs, such as azole drugs. Multifactorial and multistep alterations are involved in the azole resistance in Candida albicans. In…

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Nicotinamide potentiates amphotericin B activity against Candida albicans

Yu Yan; ZeBin Liao; Juan Shen dkk.

Virulence, Vol. 13 No. 1 · 2022 · Inggris · DOAJ Scopus

Amphotericin B (AmB) is a widely used antifungal agent especially for the therapy of systemic fungal infections. However, the severe side effects of AmB often leads to the premature termination of the treatment. So it is imperative to find the drugs that can both reduce the dosage and enhance the…

Endogenous nitric oxide accumulation is involved in the antifungal activity of Shikonin against Candida albicans

Zebin Liao; Yu Yan; Huaihuai Dong dkk.

Emerging Microbes and Infections, Vol. 5 No. 1 · 2016 · Inggris · DOAJ Scopus

The aim of the present study was to investigate the role of nitric oxide (NO) in the antifungal activity of Shikonin (SK) against Candida albicans (C. albicans) and to clarify the underlying mechanism. The results showed that the NO donors S-nitrosoglutathione (GSNO) and L-arginine could enhance…

Metabonomics on Candida albicans indicate the excessive H3K56ac is involved in the antifungal activity of Shikonin

ZeBin Liao; ZhenYu Zhu; Ling Li dkk.

Emerging Microbes and Infections, Vol. 8 No. 1 · 2019 · Inggris · DOAJ Scopus

Development of antifungal agents with novel mechanism and low toxicity are essential due to the prevalence of the infectious diseases caused by Candida albicans. The current study employed a new research method, which combined the ultra-high performance liquid chromatography with quadrupole…

E0703 targets ERβ to facilitate the upregulation of GLI3, thereby alleviating irradiation-induced DNA damage on lymphocytes

Zebin Liao; Liangliang Zhang; Zekun Wu dkk.

Cellular & Molecular Biology Letters, Vol. 30 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Background Radiotherapy for malignant tumor treatment and irradiation (IR)-related diagnosis damage lymphocytes, which inevitably suppresses immunity and leads to unwanted clinical outcomes. However, a few agents have been approved by the Food and Drug Administration (FDA) to alleviate…

PKA signaling-mediated inhibition of the AIM2 inflammasome is involved in the radioprotective effect of Eleutheroside E

Liangliang Zhang; Changkun Hu; Zekun Wu dkk.

Acupuncture and Herbal Medicine, Vol. 5 No. 4 · 2025 · Inggris · DOAJ Scopus

Objective:. To investigate the protective effect and underlying mechanism of Eleutheroside E (EE), derived from Acanthopanax senticosus, against γ-ray radiation-induced splenic injury. Methods:. The Cell Counting Kit-8 assay was used to determine the toxicity of the drug. Hematoxylin and eosin…

Blocking TBK1 alleviated radiation-induced pulmonary fibrosis and epithelial-mesenchymal transition through Akt-Erk inactivation

Hongjin Qu; Lei Liu; Zhe Liu dkk.

Experimental and Molecular Medicine, Vol. 51 No. 4 · 2019 · Inggris · DOAJ Scopus

Lung cancer: Suppressing fibrosis during radiotherapy The risk of scarred tissues and respiratory distress during radiation treatment of lung cancer could be reduced by targeting an enzyme that alters healthy cells. Lung cancer radiotherapy often causes pulmonary fibrosis, excessive growth of…

Heat-killed Typhimurium protects mice against carbon ion radiation

Zebin Liao; Zhe Liu; Zhenyu Gong dkk.

Journal of International Medical Research, Vol. 48 · 2020 · Inggris · DOAJ Scopus

Objective Patients receiving carbon-ion radiation therapy and astronauts exploring outer space are inevitably exposed to heavy ion radiation. The aim of this study was to develop radioprotectors to minimize the injuries induced by carbon ion radiation. Methods Heat-killed Salmonella Typhimurium…

Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation

Zebin Liao; Congshu Huang; Liangliang Zhang dkk.

Experimental and Molecular Medicine, Vol. 58 No. 5 · 2026 · Inggris · DOAJ Scopus

Abstract The development of compounds triggering intestinal stem cells (ISCs) proliferation represents a promising strategy to alleviate irradiation (IR)-induced gastrointestinal syndrome. Here, cannabidiol (CBD)-a nonpsychotomimetic phytocannabinoid derived from the Cannabis sativa plant-was found…

The synthetic estradiol analog E0703 enhances Akkermansia muciniphila growth for radiation‐induced intestinal damage repair

Zhexin Ni; Ziqiao Yan; Mingyang Chang dkk.

mLife, Vol. 5 No. 2 · 2026 · Inggris · DOAJ Scopus

Abstract The development of safe and effective radioprotective agents with minimal side effects, particularly for high‐dose exposure, remains a global priority. E0703, a novel steroidal compound structurally derived from estradiol, has shown promising radioprotective efficacy with limited…