63 hasil untuk "Anastasios Potiris"
Menampilkan 41–60 · 0,46 detik · RSS
-
Artikel Jurnal Teks lengkap
Linking Oxidative Stress to Placental Dysfunction: The Key Role of Mitochondria in Trophoblast Function
Oxidative stress (OS) is a critical regulator of placental development; however, its specific effects on trophoblast biology remain incompletely elucidated. This narrative review synthesizes evidence derived from studies using human placental tissues and trophoblast cell models to delineate how…
-
Artikel Jurnal Teks lengkap
Bridging Andrology and Oncology: Prognostic Indicators of Cancer Among Infertile Men
Approximately 7% of males globally suffer from male infertility, which is becoming more widely acknowledged as a clinical indicator of potential health hazards as well as a cause of reproductive failure. Among these, cancer has become a significant worry due to mounting evidence that…
-
Artikel Jurnal Teks lengkap
Mitochondrial Metabolic Checkpoints in Human Fertility: Reactive Oxygen Species as Gatekeepers of Gamete Competence
Crucial regulators of gamete metabolism and signaling, mitochondria synchronize energy generation with redox equilibrium and developmental proficiency. Once thought of as hazardous byproducts, reactive oxygen species (ROS) are now understood to be vital signaling molecules that provide a “redox…
-
Artikel Jurnal Teks lengkap
The Impact of Human Papillomavirus Infections on Recurrent Pregnancy Loss: A Review of the Literature
Human papillomavirus (HPV) infections are significantly associated with multiple adverse reproductive outcomes such as miscarriages. Pregnant women are more susceptible to an HPV infection and its prevalence increases as pregnancy progresses. In this present review, we summarize the existing…
-
Artikel Jurnal Teks lengkap
Association between COVID-19 Infection and Miscarriages, What We Really Know?
Background: COVID-19 is a modern worldwide pandemic that affected and continues to affect millions of people around the world. Since the discovery that angiotensin-converting enzyme 2 (ACE2) is the binding site for COVID-19 to achieve cell entry, there has been a continuous debate about the effect…
-
Artikel Jurnal Teks lengkap
Decoding Apelin: Its Role in Metabolic Programming, Fetal Growth, and Gestational Complications
Placental insufficiency and gestational diabetes, which are both serious pregnancy complications, are linked to altered fetal growth, whether restricted or excessive, and result in metabolic dysfunction, hypoxic/oxidative injury, and adverse perinatal outcomes. Although much research has been…
-
Artikel Jurnal Teks lengkap
Prenatal Dietary Exposure to Endocrine Disruptors and Its Lasting Impact on Offspring Health
Environmental stressors during the crucial period of fetal development can have a substantial impact on long-term health outcomes. A major concern is dietary exposure to endocrine-disrupting chemicals (EDCs), which can readily cross the placenta and disrupt fetal hormonal signaling and…
-
Artikel Jurnal Teks lengkap
The Impact of Endocrine-Disrupting Chemicals on Embryonic Recurrent Implantation Failure: A Narrative Review
A significant and persistent issue in assisted reproduction is recurrent implantation failure (RIF), which is often observed even after the transfer of embryos of high morphological and/or genetic quality. Accumulating data suggest that exposure to chemicals with endocrine-disrupting effects (EDCs)…
-
Artikel Jurnal Teks lengkap
Endocrine and Molecular Mechanisms of Oocyte Aging: From Gonadotropin Signaling to Metabolic and Microenvironmental Dysfunction
Ovarian aging and oocyte aging are closely interconnected but distinct components of reproductive aging. Whereas ovarian aging encompasses progressive follicular depletion and changes in ovarian endocrine and somatic-cell function, oocyte aging refers more specifically to the age-associated…
-
Artikel Jurnal Teks lengkap
Long-Read Sequencing and Structural Variant Detection: Unlocking the Hidden Genome in Rare Genetic Disorders
Rare genetic diseases are often caused by structural variants (SVs), such as insertions, deletions, duplications, inversions, and complex rearrangements. However, due to the technical limitations of short-read sequencing, these variants remain underdiagnosed. Long-read sequencing technologies…
-
Artikel Jurnal Teks lengkap
The Gut–Extracellular Vesicle–Mitochondria Axis in Reproductive Aging: Antioxidant and Anti-Senescence Mechanisms
Cellular senescence, mitochondrial dysfunction, and cumulative oxidative stress (OS) are the main causes of the progressive decreases in oocyte and sperm quality that define reproductive age. There is growing evidence that these processes are controlled by systemic variables, such as metabolites…
-
Artikel Jurnal Teks lengkap
A Deep Learning Approach for Classifying Benign, Malignant, and Borderline Ovarian Tumors Using Convolutional Neural Networks and Generative Adversarial Networks
Background/Objectives: Accurate preoperative characterization of ovarian masses is essential for appropriate clinical management, particularly for borderline ovarian tumors (BOTs), which are less common and often difficult to distinguish from benign or malignant lesions on ultrasound. Although…
-
Artikel Jurnal Teks lengkap
Thrombocytopenia in Pregnancy: Clinical Challenges, Maternal–Fetal Risks, and Management Strategies
Thrombocytopenia affects up to 10% of pregnant women and represents the second most common blood disorder during pregnancy. Its causes include immune-mediated thrombocytopenia, hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome, preeclampsia (PE), and benign pregnant…
-
Artikel Jurnal Teks lengkap
MicroRNAs Regulating Oxidative Stress in Human Fertility: A Narrative Review of Mechanistic Insights and Clinical Potential
Human infertility represents a multifaceted condition, with oxidative stress (OS) and microRNAs (miRNAs) emerging as key contributors to its pathophysiology. This comprehensive review explores the complex interplay between reactive oxygen species (ROS) and miRNAs in male and female reproductive…
-
Artikel Jurnal Teks lengkap
Oocyte Maturation and miRNAs: Studying a Complicate Interaction to Reveal Possible Biomarkers for Female Infertility
Cellular metabolism, apoptosis, fertilization, and proliferation of granulosa cells belong to a battery of processes where microRNAs can be detected and associated with infertility. The aim of the present review is to focus on mammalian oocyte maturation events and the association between oocyte…
-
Artikel Jurnal Teks lengkap
From Prenatal Exposure to Adult Sexual Dysfunction: The Impact of Plastic-Derived Endocrine Disruptors on Testosterone Homeostasis and Erectile Function
Bisphenols, phthalates, and other plastic-associated compounds are endocrine-disrupting chemicals (EDCs), common environmental contaminants that can disrupt hormonal homeostasis. Human exposure to such chemicals occurs mainly through food packaging, consumer goods, medical devices, and the…
-
Artikel Jurnal Teks lengkap
Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health
Chronic inflammation is increasingly recognized as a critical factor in female reproductive health; influencing natural conception and the outcomes of assisted reproductive technologies such as in vitro fertilization (IVF). An essential component of innate immunity, the NLR family pyrin…
-
Artikel Jurnal Teks lengkap
miR-27a rs895819 Polymorphism and Recurrent Pregnancy Loss in Caucasian Women: A Novel Genetic Risk Factor in a Challenging Fertility Dilemma
Background: This case–control study investigates whether miR-27a rs895819 A>G polymorphism is associated with an increased risk of recurrent pregnancy loss (RPL) in Caucasian Greek women. Methods: This study included 93 women with at least two unexplained miscarriages before the 24th week of…
-
Artikel Jurnal Teks lengkap
The Impact of Endocrine Disruptor Exposure During Pregnancy on Bacterial Complications and Viral Infections: A Narrative Review
Endocrine-disrupting chemicals (EDCs) are a diverse group of environmental pollutants capable of interfering with hormonal and immune system regulation. In recent years, increasing concern has been raised about the effects of chemicals, including bisphenols, phthalates, per- and polyfluoroalkyl…
-
Artikel Jurnal Teks lengkap
From Inflammation to Infertility: How Oxidative Stress and Infections Disrupt Male Reproductive Health
Background/Objectives: Inflammation, infections, and oxidative stress (OS) all have an impact on male infertility, which is a complicated, multifaceted illness. OS affects motility and fertilization capability. It accomplishes this through damaging sperm DNA, oxidizing proteins, and triggering…