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Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications
Regulated cell death (RCD) refers to the form of cell death that can be regulated by various biomacromolecules. Each cell death modalities have their distinct morphological changes and molecular mechanisms. However, intense evidences suggest that lipid peroxidation can be the common feature that…
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Services Integration in Tanzania e-Government Systems
The interoperability of information systems for public organizations is a significant opportunity for improved delivery of e-government services. However, the lack of e-government services integration is one of the issues preventing services from effectively reaching citizens in many developing…
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Bacterial persisters: molecular mechanisms and therapeutic development
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing) bacteria that survive in stress environments such as antibiotic exposure, acidic and starvation conditions. These cells can regrow after stress removal and remain susceptible to the same stress. Persisters are…
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AI hallucination: towards a comprehensive classification of distorted information in artificial intelligence-generated content
Amidst the burgeoning information age, the rapid development of artificial intelligence-generated content (AIGC) has brought forth challenges regarding information authenticity. The proliferation of distorted information significantly impacts users negatively. This study aims to systematically…
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The Atacama Cosmology Telescope: A Measurement of the DR6 CMB Lensing Power Spectrum and Its Implications for Structure Growth
Abstract We present new measurements of cosmic microwave background (CMB) lensing over 9400 deg 2 of the sky. These lensing measurements are derived from the Atacama Cosmology Telescope (ACT) Data Release 6 (DR6) CMB data set, which consists of five seasons of ACT CMB temperature and polarization…
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Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice
Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal TLR9 response is incompletely understood. Here, we report that palmitoyl-protein thioesterase 1 (PPT1) regulates systemic…
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The Evolving Microbiome of Dental Caries
Dental caries is a significant oral and public health problem worldwide, especially in low-income populations. The risk of dental caries increases with frequent intake of dietary carbohydrates, including sugars, leading to increased acidity and disruption of the symbiotic diverse and complex…
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The second data release from the European Pulsar Timing Array
The European Pulsar Timing Array (EPTA) and Indian Pulsar Timing Array (InPTA) collaborations have measured a low-frequency common signal in the combination of their second and first data releases, respectively, with the correlation properties of a gravitational wave background (GWB). Such a signal…
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The First LHAASO Catalog of Gamma-Ray Sources
Abstract We present the first catalog of very-high-energy and ultra-high-energy gamma-ray sources detected by the Large High Altitude Air Shower Observatory. The catalog was compiled using 508 days of data collected by the Water Cherenkov Detector Array from 2021 March to 2022 September and 933…
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A critical assessment of using ChatGPT for extracting structured data from clinical notes
Existing natural language processing (NLP) methods to convert free-text clinical notes into structured data often require problem-specific annotations and model training. This study aims to evaluate ChatGPT's capacity to extract information from free-text medical notes efficiently and…
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A NICER View of the Nearest and Brightest Millisecond Pulsar: PSR J0437–4715
Abstract We report Bayesian inference of the mass, radius, and hot X-ray emitting region properties—using data from the Neutron Star Interior Composition ExploreR (NICER)—for the brightest rotation-powered millisecond X-ray pulsar, PSR J0437−4715. Our modeling is conditional on informative tight…
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GPT is an effective tool for multilingual psychological text analysis
The social and behavioral sciences have been increasingly using automated text analysis to measure psychological constructs in text. We explore whether GPT, the large-language model (LLM) underlying the AI chatbot ChatGPT, can be used as a tool for automated psychological text analysis in several…
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Green spaces provide substantial but unequal urban cooling globally
Climate warming disproportionately impacts countries in the Global South by increasing extreme heat exposure. However, geographic disparities in adaptation capacity are unclear. Here, we assess global inequality in green spaces, which urban residents critically rely on to mitigate outdoor heat…
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A Comparison of Several Linear Genetic Programming Techniques
A comparison between four Genetic Programming techniques is presented in this paper. The compared methods are Multi-Expression Programming, Gene Expression Programming, Grammatical Evolution, and Linear Genetic Programming. The comparison includes all aspects of the considered evolutionary…
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Possibilities and limitations of antisense oligonucleotide therapies for the treatment of monogenic disorders
Antisense oligonucleotides (ASOs) are incredibly versatile molecules that can be designed to specifically target and modify RNA transcripts to slow down or halt rare genetic disease progression. They offer the potential to target groups of patients or can be tailored for individual cases…
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In situ modulating coordination fields of single-atom cobalt catalyst for enhanced oxygen reduction reaction
Abstract Single-atom catalysts, especially those with metal−N 4 moieties, hold great promise for facilitating the oxygen reduction reaction. However, the symmetrical distribution of electrons within the metal−N 4 moiety results in unsatisfactory adsorption strength of intermediates, thereby…
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Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer
BACKGROUND: Retrospective data suggest that the incidence of parametrial infiltration is low in patients with early-stage low-risk cervical cancer, which raises questions regarding the need for radical hysterectomy in these patients. However, data from large, randomized trials comparing outcomes of…
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Monitoring Ti 3 C 2 T x MXene Degradation Pathways Using Raman Spectroscopy
High Resolution Image Download MS PowerPoint Slide Extending applications of Ti 3 C 2 T x MXene in nanocomposites and across fields of electronics, energy storage, energy conversion, and sensor technologies necessitates simple and efficient analytical methods. Raman spectroscopy is a critical tool…
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Job demands–resources theory: Frequently asked questions.
Job demands-resources (JD-R) theory is commonly used to predict employee well-being, work behaviors, and performance. This article provides a short description of JD-R theory and discusses issues and questions that have been raised regarding the theory. These issues include the differences between…
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