40,148 results
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Advancements in Hydrogels: A Comprehensive Review of Natural and Synthetic Innovations for Biomedical Applications
In the rapidly evolving field of biomedical engineering, hydrogels have emerged as highly versatile biomaterials that bridge biology and technology through their high water content, exceptional biocompatibility, and tunable mechanical properties. This review provides an integrated overview of both…
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Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels
BACKGROUND: Endovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and effective. The effect of EVT for occlusion of medium or distal vessels is unclear. METHODS: We randomly assigned participants with an isolated occlusion of medium or distal vessels (occlusion of…
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Trust in scientists and their role in society across 68 countries
Science is crucial for evidence-based decision-making. Public trust in scientists can help decision makers act on the basis of the best available evidence, especially during crises. However, in recent years the epistemic authority of science has been challenged, causing concerns about low public…
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Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis
BACKGROUND: Obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, provided significantly better renal responses than placebo in a phase 2 trial involving patients with lupus nephritis receiving standard therapy. METHODS: In a phase 3, randomized, controlled trial, we assigned adults with…
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Network pharmacology: a crucial approach in traditional Chinese medicine research
Network pharmacology plays a pivotal role in systems biology, bridging the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research. Network pharmacology enables researchers to construct multilayered networks that systematically elucidate TCM's…
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Advances in cancer immunotherapy: historical perspectives, current developments, and future directions
Cancer immunotherapy, encompassing both experimental and standard-of-care therapies, has emerged as a promising approach to harnessing the immune system for tumor suppression. Experimental strategies, including novel immunotherapies and preclinical models, are actively being explored, while…
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Self-assembled bilayer for perovskite solar cells with improved tolerance against thermal stresses
The adoption of perovskite solar cells (PSCs) requires improved resistance to high temperatures and temperature variations. Hole-selective self-assembled monolayers (SAMs) have enabled progress in the performance of inverted PSCs, yet they may compromise temperature stability owing to desorption…
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Advances in lignocellulosic feedstocks for bioenergy and bioproducts
Lignocellulose, an abundant renewable resource, presents a promising alternative for sustainable energy and industrial applications. However, large-scale adoption of lignocellulosic feedstocks faces considerable obstacles, including scalability, bioprocessing efficiency, and resilience to climate…
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Book Full text
Single Piles and Pile Groups Under Lateral Loading
The complexities of designing piles for lateral loads are manifold as there are many forces that are critical to the design of big structures such as bridges, offshore and waterfront structures, and retaining walls. The loads on structures should be supported either horizontally or laterally or in…
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Cancer treatment and survivorship statistics, 2025
The number of people living with a history of cancer in the United States continues to rise because of the growth and aging of the population as well as improved survival through advances in early detection and treatment. To assist the public health community serve the needs of these survivors, the…
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A comprehensive survey of deep learning for time series forecasting: architectural diversity and open challenges
Abstract Time series forecasting is a critical task that provides key information for decision-making across various fields, such as economic planning, supply chain management, and medical diagnosis. After the use of traditional statistical methodologies and machine learning in the past, various…
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Guidance on the planning and reporting of experimental design and analysis
The aim of this guidance document is to help authors plan experiments, conduct analyses and present the results of work intended for publication in the British Journal of Pharmacology (BJP).The guidance is structured to minimize the risk of generating and publishing false findings.Below, we explain…
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Once-Weekly Semaglutide in Adults With Alcohol Use Disorder
Importance: Preclinical, observational, and pharmacoepidemiology evidence indicates that glucagon-like peptide 1 receptor agonists (GLP-1RAs) may reduce alcohol intake. Randomized trials are needed to determine the clinical significance of these findings. Objective: To evaluate the effects of…
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A guidance to intelligent metamaterials and metamaterials intelligence
The bidirectional interactions between metamaterials and artificial intelligence have recently attracted immense interest to motivate scientists to revisit respective communities, giving rise to the proliferation of intelligent metamaterials and metamaterials intelligence. Owning to the strong…
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Microservices Architecture
This paper provides a comprehensive overview of microservices architecture, focusing on its implementation.We discuss the core principles, key components, deployment considerations, challenges, and best practices for building robust and scalable microservices-based applications with C#.The paper…
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CRITICAL SUCCESS FACTORS ACROSS THE PROJECT LIFE CYCLE
Determining project achievement indicators from the beginning of its establishment is one of the most important success factors that must be clearly documented for all parties involved in the project to achieve high fluidity during implementation, which is done through the application of project…
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Phenylpropanoids metabolism: recent insight into stress tolerance and plant development cues
The phenylpropanoid pathway remains a key target for most climate-resilient crop development, owing to it being a precursor to over 8000 metabolites, including flavonoids and lignin compounds, including their derivatives. These metabolites are involved in biotic and abiotic stress tolerance…
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Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies
Extracellular vesicles share lipid‒protein membranes with their parent cells, allowing for the targeted transfer of bioactive cargo to recipient cells for functional modulation. The biological features allow extracellular vesicles to serve both as intrinsic therapeutics and as engineered delivery…
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Post-growth: the science of wellbeing within planetary boundaries
There are increasing concerns that continued economic growth in high-income countries might not be environmentally sustainable, socially beneficial, or economically achievable. In this Review, we explore the rapidly advancing field of post-growth research, which has evolved in response to these…
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