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Journal Article
Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury
Elevated lactate levels are a significant biomarker of sepsis and are positively associated with sepsis-related mortality. Sepsis-associated lung injury (ALI) is a leading cause of poor prognosis in clinical patients. However, the underlying mechanisms of lactate's involvement in sepsis-associated…
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Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide
Importance: Anecdotal experience raised the possibility that semaglutide, a glucagon-like peptide 1 receptor agonist (GLP-1 RA) with rapidly increasing use, is associated with nonarteritic anterior ischemic optic neuropathy (NAION). Objective: To investigate whether there is an association between…
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Precisely Tailoring Molecular Structure of Doxorubicin Prodrugs to Enable Stable Nanoassembly, Rapid Activation, and Potent Antitumor Effect
Background: Achieving a balance between stable drug loading/delivery and on-demand drug activation/release at the target sites remains a significant challenge for nanomedicines. Carrier-free prodrug nanoassemblies, which rely on the design of prodrug molecules, offer a promising strategy to…
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Borderline personality disorder: a comprehensive review of diagnosis and clinical presentation, etiology, treatment, and current controversies
Borderline personality disorder (BPD) was introduced in the DSM-III in 1980. From the DSM-III to the DSM-5, no major changes have occurred in its defining criteria. The disorder is characterized by instability of self-image, interpersonal relationships and affects. Further symptoms include…
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A Comprehensive Review on Exploring the Impact of Telemedicine on Healthcare Accessibility
Telemedicine has emerged as a transformative force in healthcare delivery, particularly in improving healthcare accessibility. This comprehensive review examines the impact of telemedicine on healthcare accessibility, exploring its ability to overcome geographical, financial, sociocultural, and…
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MetaboAnalystR 4.0: a unified LC-MS workflow for global metabolomics
The wide applications of liquid chromatography - mass spectrometry (LC-MS) in untargeted metabolomics demand an easy-to-use, comprehensive computational workflow to support efficient and reproducible data analysis. However, current tools were primarily developed to perform specific tasks in LC-MS…
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Biogas: Production, properties, applications, economic and challenges: A review
Biogas is obtained from the breakdown of biomass by microorganisms and bacteria in the absence of oxygen. Biogas is considered a renewable source of energy, similar to solar energy and wind energy. Biogas can be produced from biomass or bio-waste; thus, it is environmentally friendly. Biogas is…
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A comprehensive review on smart and sustainable agriculture using IoT technologies
The article provides a comprehensive review of the use of the Internet of Things (IoT) in agriculture, along with its advantages and disadvantages. However, it's important to recognize that IoT holds immense potential for generating new ideas that could drive innovations in modern agriculture and…
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Diseño y Construcción de un Biodigestor para la Producción de Biogás a partir de Residuos Orgánicos en Bolivia
En la historia boliviana, nuestro país se ha caracterizado por su extracción y exportación de gas natural convirtiéndose en una fuente importante de ingresos y desarrollo económico, sin embargo diversos factores han llevado a una crisis general del gas, Bolivia se ha convertido en un país sumamente…
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Advances on the Global Human Settlement Layer by joint assessment of Earth Observation and population survey data
The Global Human Settlement Layer (GHSL) project fosters an enhanced, public understanding of the human presence on Earth. A decade after its inception in the Digital Earth 2020 vision, GHSL is an established project of the European Commission’s Joint Research Centre and an integral part of the…
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Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation
Fibroblasts, known for their functional diversity, play crucial roles in inflammation and cancer. In this study, we conduct comprehensive single-cell RNA sequencing analyses on fibroblast cells from 517 human samples, spanning 11 tissue types and diverse pathological states. We identify distinct…
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Cancer epigenetics: from laboratory studies and clinical trials to precision medicine
Epigenetic dysregulation is a common feature of a myriad of human diseases, particularly cancer. Defining the epigenetic defects associated with malignant tumors has become a focus of cancer research resulting in the gradual elucidation of cancer cell epigenetic regulation. In fact, most stages of…
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Biochar Production and Characteristics, Its Impacts on Soil Health, Crop Production, and Yield Enhancement: A Review
Rapid urban expansion and a booming population are placing immense pressure on our agricultural systems, leading to detrimental impacts on soil fertility and overall health. Due to the extensive use of agrochemicals in agriculture, the necessity to meet the expanding demand for food has also…
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Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications
The gastrointestinal tract is home to trillions of diverse microorganisms collectively known as the gut microbiota, which play a pivotal role in breaking down undigested foods, such as dietary fibers. Through the fermentation of these food components, short-chain fatty acids (SCFAs) such as…
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Efficient tandem electroreduction of nitrate into ammonia through coupling Cu single atoms with adjacent Co3O4
Abstract The nitrate (NO3−) electroreduction into ammonia (NH3) represents a promising approach for sustainable NH3 synthesis. However, the variation of adsorption configurations renders great difficulties in the simultaneous optimization of binding energy for the intermediates. Though the…
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Red-billed blue magpie optimizer: a novel metaheuristic algorithm for 2D/3D UAV path planning and engineering design problems
Abstract Numerical optimization, Unmanned Aerial Vehicle (UAV) path planning, and engineering design problems are fundamental to the development of artificial intelligence. Traditional methods show limitations in dealing with these complex nonlinear models. To address these challenges, the swarm…
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A review on fundamentals for designing hydrogen evolution electrocatalyst
As a clean, efficient, and renewable energy source, hydrogen has always been recognized as a favourable replacement of fossil fuel. A primary challenge is an efficient generation of hydrogen to fulfil the requirements of hydrogen on a commercial scale. The electrocatalytic process of HER (hydrogen…
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Cellular ATP demand creates metabolically distinct subpopulations of mitochondria
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Drones in Precision Agriculture: A Comprehensive Review of Applications, Technologies, and Challenges
In the face of growing challenges in modern agriculture, such as climate change, sustainable resource management, and food security, drones are emerging as essential tools for transforming precision agriculture. This systematic review, based on an in-depth analysis of recent scientific literature…
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