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Artikel Jurnal
Steatotic liver-derived extracellular vesicles deliver ACSL4 to potentiate hepatic ischemia–reperfusion injury by orchestrating a ferroptosis-mitochondrial apoptosis cascade
Steatotic liver grafts exhibit heightened susceptibility to hepatic ischemia–reperfusion injury (HIRI), contributing to poor outcomes in liver transplantation; however, the underling mechanisms remain incompletely defined. Here, we demonstrate that extracellular vesicles derived from steatotic…
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Artikel Jurnal
Functions of exosome-derived noncoding RNA-encoded polypeptides/proteins in human diseases
Exosomes are nanoscale vesicles that are ubiquitously present in biological fluids and exhibit remarkable stability, carrying a diverse array of biologically active molecules, including various RNAs, DNAs, and proteins. Exosomes are crucial mediators of intercellular signaling and exert extensive…
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Artikel Jurnal
Influence of oncogenic drivers and signaling pathways on immune checkpoint inhibitor efficacy in NSCLC
Non-small cell lung cancer (NSCLC) is characterized by intricate genetic modifications and mechanisms that allow it to evade immune detection, which complicates the pursuit of lasting therapeutic responses. The effectiveness of treatments is greatly affected by the interaction between tumor genetic…
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Artikel Jurnal
ONC201/dordaviprone for H3 K27M-mutant tumors: Discovery, mechanisms, therapeutic potential, and future directions
ONC201 (dordaviprone) has recently received accelerated approval for the treatment of recurrent H3 K27M–mutant diffuse midline glioma. Originally identified as TRAIL-inducing compound 10 (TIC10), ONC201 is a first-in-class small molecule distinguished by a unique pharmacologic profile. It promotes…
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Artikel Jurnal
Necroptosis-related diseases are regulated by the unfolded protein response during endoplasmic reticulum stress
In recent years, research has highlighted that necroptosis plays a significant role in various diseases, suggesting that studying the pathways of necroptosis may offer novel avenues for developing treatments for these conditions. The classical necroptosis pathway involves the activation and…
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Artikel Jurnal
Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights
Metabolic reprogramming is an important factor contributing to tumor medication resistance and recurrence in cancer cells. There is ample proof that metabolic remodeling is vital in colorectal cancer’s genesis, progression, and resistance to treatment. The molecular processes behind changes in…
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Artikel Jurnal
Lactylation: Metabolic epigenetic regulation and cell death mechanisms in myocardial ischemia‒reperfusion injury
One important pathogenic process that contributes to subsequent damage after myocardial infarction (MI) revascularization is myocardial ischemia/reperfusion injury (MI/RI). Its underlying mechanisms are controlled by traditional post-translational modifications (PTMs) like acetylation, methylation…
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Artikel Jurnal
Autosomal dominant gain-of-function mutations in LCP1 cause a syndromic neutropenia and immunodeficiency
Actin cytoskeleton defects underlie immuno-actinopathies. We identified three patients with heterozygous LCP1 gain-of-function mutations (L362F, A365D) causing activated LCP1-associated immunodeficiency syndrome, characterized by congenital neutropenia, variable combined immunodeficiency, and…
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Artikel Jurnal
PINK1 deficiency exacerbates age-related bone loss in association with enhanced inflammatory adipocyte differentiation
Age-related bone loss contributes to frailty, fractures, and increased mortality in the elderly, yet current osteoporosis treatments have limited long-term efficacy. Mitochondrial dysfunction is a hallmark of skeletal aging, but its role in mesenchymal lineage commitment remains unclear. Here, we…
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Artikel Jurnal
ZO-2 blocks the localization of PGAM5 protein to the mitochondrial membrane and suppresses pancreatic cancer malignancy through metabolic reprogramming
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death with limited treatment options, and there is an urgent need to develop effective therapeutic strategies. The zonula occludens-2 (ZO-2) protein is a member of the tight junction protein family, and its…
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Artikel Jurnal
Single-cell sequencing-guided discovery of narciclasine as a dual VCAM-1/ICAM-1 inhibitor for atherosclerosis management
Atherosclerosis (AS) remains a leading cause of cardiovascular morbidity and mortality worldwide, with current treatments focused primarily on reducing low-density lipoprotein levels while failing to repair damaged endothelial cells, thus highlighting the urgent need for novel therapeutic drugs. To…
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Artikel Jurnal
High-throughput chemical screen identifies epothilone B in modulating inflammatory bowel disease by triggering neutrophil apoptosis
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract characterized by a complex interplay of genetic, environmental, and immunological factors. Neutrophils, as a key component of the innate immune system, play a critical role in IBD pathogenesis due to…
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Artikel Jurnal
Micellar LYTAC-engineered bionic coatings abrogate RANK-dependent osteocatabolism and boost fibrillogenesis-mimetic mineral accretion for empowering osteoporotic osseointegration
Patients with osteoporosis are highly susceptible to fractures that often require implant fixation and stabilization. However, excessive osteoclast activity under osteoporotic conditions accelerates bone resorption at the bone-implant interface, severely compromising implant osseointegration…
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Artikel Jurnal
Targeted inhibition of inflammatory liver macrophages with a multifunctional nanoparticle ameliorates metabolic dysfunction–associated steatohepatitis
Despite metabolic dysfunction–associated steatohepatitis (MASH) being a significant global health concern, there are few effective ways to prevent or treat MASH. Evidence from preclinical and clinical studies suggests that inflammatory polarization of Kupffer cells (KCs) and infiltration of…
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Artikel Jurnal
Data-driven surrogate modeling of FLUKA-generated ambient dose equivalent distributions in an asymmetric proton accelerator shielding system
Accurate determination of spatial ambient dose equivalent H*(10) distributions in high-energy proton accelerator facilities is essential for radiation protection and shielding design. In this study, spatial ambient dose equivalent H*(10) distributions produced under a proton beam-loss scenario were…
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Artikel Jurnal Teks lengkap
Structure-property relationships in 2D/quasi-2D lead-free halide double perovskites for optoelectronic devices
Two-dimensional (2D) and quasi-2D lead-free halide double perovskites (LFHDPs) have gained significant attention as promising alternatives to conventional lead-based perovskites due to their superior environmental stability, reduced toxicity and versatile structural chemistry. This review provides…
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Artikel Jurnal
Harnessing synthetic microbial communities for desert vegetation restoration
The core bottleneck for desert vegetation restoration is extreme water stress during early seedling establishment, with hydraulic failure as the primary lethal mechanism. Traditional engineering measures (e.g., irrigation) and single-strain inoculation cannot adequately address these challenges due…
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Artikel Jurnal
Emerging biomarkers for human parasitic infections: Advances and future perspectives
Parasitic infections remain a major global public health challenge, disproportionately affecting populations in low- and middle-income countries and contributing to significant morbidity, mortality, and socioeconomic burden. Accurate and timely diagnosis is essential for effective disease control…
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Artikel Jurnal
Advancing smart school initiatives: A case study of Zahedan city
This mixed-methods case study evaluates Iran's Smart Schools Project in Zahedan, a socioeconomically heterogeneous city, to identify barriers and scalable interventions for technology-enhanced schooling in resource-constrained contexts. Data comprise structured surveys (n = 150), semi-structured…
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Artikel Jurnal
Critical review of tools and techniques for predicting microplastics pollution in watershed runoff
Microplastics (MPs) pollution, especially, stormwater runoff from non-point sources is a major source of MPs into surrounding soils and aquatic environment. Numerous studies have investigated MPs occurrence, distribution, sources, morphology, environmental impact, and fate and transport (F&T)…
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