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NCBI RefSeq: reference sequence standards through 25 years of curation and annotation
Reference sequences and annotations serve as the foundation for many lines of research today, from organism and sequence identification to providing a core description of the genes, transcripts and proteins found in an organism's genome. Interpretation of data including transcriptomics, proteomics…
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Interplay of oxidative stress, cellular communication and signaling pathways in cancer
Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized by the production of reactive oxygen species (ROS) within cells, plays a critical role in the development of cancer by affecting genomic stability and…
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Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after confirmed severe acute respiratory syndrome coronavirus 2 infection. Analysis of >6500 proteins in 268 longitudinal samples…
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The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review
Mercury is a type of hazardous and toxic pollutant that can result in detrimental effects on the environment and human health. This review is aimed at discussing the state-of-the-art progress on the recent developments on the toxicity of mercury and its chemical compounds. More than 210 recent…
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Fleischner Society: Glossary of Terms for Thoracic Imaging
Members of the Fleischner Society have compiled a glossary of terms for thoracic imaging that replaces previous glossaries published in 1984, 1996, and 2008, respectively. The impetus to update the previous version arose from multiple considerations. These include an awareness that new terms and…
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Cell–cell communication: new insights and clinical implications
Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell-cell communication (CCC) is essential for growth, development, differentiation, tissue and organ formation, maintenance, and physiological regulation. Cells communicate…
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Deep learning-based structural health monitoring
This article provides a comprehensive review of deep learning-based structural health monitoring (DL-based SHM). It encompasses a broad spectrum of DL theories and applications including nondestructive approaches; computer vision-based methods, digital twins, unmanned aerial vehicles (UAVs), and…
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The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity
The NHGRI-EBI GWAS Catalog serves as a vital resource for the genetic research community, providing access to the most comprehensive database of human GWAS results. Currently, it contains close to 7 000 publications for >15 000 traits, from which more than 625 000 lead associations have been…
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DriveGPT4: Interpretable End-to-End Autonomous Driving Via Large Language Model
Multimodallarge language models (MLLMs) have emerged as a prominent area of interest within the research community, given their proficiency in handling and reasoning with non-textual data, including images and videos. This study seeks to extend the application of MLLMs to the realm of autonomous…
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Innovative Adsorbents for Pollutant Removal: Exploring the Latest Research and Applications
The growing presence of diverse pollutants, including heavy metals, organic compounds, pharmaceuticals, and emerging contaminants, poses significant environmental and health risks. Traditional methods for pollutant removal often face limitations in efficiency, selectivity, and sustainability. This…
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Human-AI collaboration patterns in AI-assisted academic writing
Artificial Intelligence (AI) has increasingly influenced higher education, notably in academic writing where AI-powered assisting tools offer both opportunities and challenges.Recently, the rapid growth of generative AI (GAI) has brought its impacts into sharper focus, yet the dynamics of its…
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Metabolic reprogramming in liver fibrosis
Chronic liver diseases, primarily metabolic dysfunction-associated steatotic liver disease (MASLD), harmful use of alcohol, or viral hepatitis, may result in liver fibrosis, cirrhosis, and cancer. Hepatic fibrogenesis is a complex process with interactions between different resident and…
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A total scoring system and software for complex modified GAPI (ComplexMoGAPI) application in the assessment of method greenness
Evaluating analytical methods with innovative metrics is essential to ensure the effectiveness of analytical procedures. Various approaches have been proposed to assess the performance of an analytical method and its environmental consequences, as sustainable environment and green chemistry…
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GENCODE 2025: reference gene annotation for human and mouse
GENCODE produces comprehensive reference gene annotation for human and mouse. Entering its twentieth year, the project remains highly active as new technologies and methodologies allow us to catalog the genome at ever-increasing granularity. In particular, long-read transcriptome sequencing enables…
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Preparation and Identification of Magnetic Iron Nanoparticle based on a Natural Hydrogel and its Performance in Targeted Drug Delivery
Billions of dollars are spent annually in the world to treat and investigate problems caused by drug side effects. According to the estimates of health researchers, about 40%of people who take medicine suffer from side effects. In this way, the necessity of using a targeted system in order to…
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Integration of renewable energy sources in tandem with electrolysis: A technology review for green hydrogen production
The global shift toward sustainable energy solutions emphasises the urgent need to harness renewable sources for green hydrogen production, presenting a critical opportunity in the transition to a low-carbon economy. Despite its potential, integrating renewable energy with electrolysis to produce…
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Properties of FDA-approved small molecule protein kinase inhibitors: A 2024 update
Owing to the dysregulation of protein kinase activity in many diseases including cancer, this enzyme family has become one of the most important drug targets in the 21st century. There are 80 FDA-approved therapeutic agents that target about two dozen different protein kinases and seven of these…
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Evaluation of clinical prediction models (part 2): how to undertake an external validation study
External validation studies are an important but often neglected part of prediction model research. In this article, the second in a series on model evaluation, Riley and colleagues explain what an external validation study entails and describe the key steps involved, from establishing a high…
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Using and Interpreting Fixed Effects Models
ABSTRACT Fixed effects (FE) have emerged as a ubiquitous and powerful tool for eliminating unwanted variation in observational accounting studies. Unwanted variation is plentiful in accounting research because we often use rich data to test precise hypotheses derived from abstract theories. By…
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Sample size for saturation in qualitative research: Debates, definitions, and strategies
Data saturation is a cornerstone concept in qualitative research, ensuring that data collection ceases once no new themes, insights, or patterns emerge. This concept is critical for achieving methodological rigor, as saturation enhances the credibility and completeness of research findings. Despite…
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