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Bacteria producing the bioplastic polyhydroxybutyrate kill the nematode Caenorhabditis elegans
Bacteria, both individually and as symbionts of other organisms, significantly influence ecosystems by providing nutrients and metabolizing exogenous compounds. Some bacteria polymerize small organic acids such as lactate, pyruvate, and β-or 3-hydroxybutyrate when there is an excess of carbon…
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Dynamic cholinergic signaling differentially desynchronizes cortical microcircuits dependent on modulation rate and network connectivity
Acetylcholine (ACh) affects both the intrinsic properties of individual neurons and the oscillatory tendencies of cortical microcircuits by modulating the muscarinic-receptor gated m-current. ACh concentrations have historically been assumed to vary exclusively over long (supra-second)…
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Diagnosis and therapeutic outcomes of biopsy-confirmed Pure Neuritic Leprosy: A two-decade experience
Background: Pure neuritic leprosy (PNL) is a distinct form of leprosy characterized by peripheral nerve involvement without skin lesions. Diagnosis is often delayed, and ‘silent neuritis’ contributes to progressive and irreversible nerve damage. Despite appropriate therapy, many patients develop…
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Transcriptional signatures of rapid protection from Sudan virus infection by a single dose of a vesicular stomatitis virus-based vaccine
Sudan virus (SUDV) has caused multiple outbreaks of human disease with case fatality rates ranging from 41 to 100%. We have previously shown that a single vaccination with a recombinant vesicular stomatitis virus-based vaccine expressing the SUDV-Gulu glycoprotein (VSV-SUDV) prevented clinical and…
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Climatic and socio-environmental drivers of Cholera epidemics: Cascading effects and spatial variability in developing regions
Cholera remains a persistent public health challenge in developing countries, driven by poor Water, Sanitation and Hygiene (WASH) infrastructure and weak healthcare systems. Growing evidence highlights the significant role of climatic factors such as temperature, rainfall variability (floods and…
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Association of serum irisin levels with postoperative cognitive dysfunction in older patients following total hip or knee arthroplasty: A prospective observational study
Background: Postoperative cognitive dysfunction (POCD) is a frequent complication in older patients undergoing hip and knee arthroplasty. While irisin has demonstrated benefits in neurological disorders associated with cognitive impairment, its role in POCD remains unclear. This study investigated…
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Maternal regulation of translation capacity across generations
How animals allocate resources between growth, maintenance, and reproduction is a fundamental question. In this issue of PLOS Biology, Pradhan and colleagues show that maternal nutrient sensing regulates ribosome deposition into embryos, shaping the early growth dynamics in the next generation…
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Correction: Quantify unmet medical need across the disease landscape – A large language model-based methodology
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The AI adaptation divide in medical education: A generational perspective
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Strategies in immune subversion: How Yersinia pestis inhibits neutrophil responses
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Correction: An essential gene screening identifies yeast Mot1 as a suppressor of R-loops and genome instability
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PLoS Medicine Issue Image | Vol. 23(2) April 2026
: Notable changes in the global health funding landscape pose significant challenges to essential tuberculosis (TB) services in low- and middle-income countries. In a modelling study, Allison Portnoy and colleagues investigate the potential impact of reduced international donor funding on the…
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Spatial prediction of dog population distribution in Kenya
Free-roaming dogs pose a significant public health concern due to their role in disease transmission. Rabies has been endemic in Kenya for over a century, yet a sustainable and standardized method for estimating dog populations remains unestablished. To address this gap, we applied kriging and…
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From visual attention to behavioural intention: A relational framework of culturally creative desserts in museum communication
This study examines how the visual presentation of culturally creative desserts (CCDs), modelled after Chinese museum artefacts, relates to potential visitors’ visit-related behavioural intention under first-exposure, image-mediated conditions. Drawing on the AIDA model, this study develops a…
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Diversity patterns in terrestrial tetrapod clades are governed by equilibrium dynamics
Large-scale patterns of species richness have been attributed to ecological limits, variation in diversification rates, and differences in evolutionary time, yet the relative importance of these drivers remains debated. Here, we present a unifying framework distinguishing four richness-generating…
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PoPI: A machine learning-based consensus mechanism for blockchain-enabled IoT systems
Internet of Things (IoT) enables seamless connectivity and intelligent automation across diverse domains, from healthcare and agriculture to smart cities and industrial systems. However, conventional IoT architectures often rely on centralized servers for data processing and coordination, resulting…
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Role of AtCPK5 and AtCPK6 in the regulation of the plant immune response triggered by rhamnolipids in Arabidopsis
Rhamnolipids (RLs) are bacterial glycolipids with potential applications in the biocontrol of plant pathogens. Although RLs are known to activate plant immune responses, the underlying signaling mechanisms remain poorly understood. Calcium-dependent protein kinases (CPKs) are a large family of…
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Hospitalizations associated with endemic and non-endemic mosquito-borne arboviruses in Canada, 2002–2023
Mosquito-borne arboviruses pose a growing public health concern in Canada, particularly in the context of climate change and increased global travel. This study aimed to quantify the burden of endemic and non-endemic mosquito-transmitted arboviral diseases in Canada by examining hospitalization…
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