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Mechanisms of sex differences in Alzheimer’s disease
Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are complex and multifactorial. The higher AD risk in women may serve as a clue to better understand these complicated processes. In this review, we examine aspects of AD that demonstrate sex-dependent effects and…
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Renal Cell Carcinoma
Importance: Renal cell carcinoma (RCC) is a common malignancy, with an estimated 434 840 incident cases worldwide in 2022. In the US, it is the sixth most common cancer among males and ninth among females. Observations: Clear cell RCC is the most common histologic subtype (75%-80% of cases) and is…
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A survey on LLM-based multi-agent systems: workflow, infrastructure, and challenges
Abstract The pursuit of more intelligent and credible autonomous systems, akin to human society, has been a long-standing endeavor for humans. Leveraging the exceptional reasoning and planning capabilities of large language models (LLMs), LLM-based agents have been proposed and have achieved…
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The NANOGrav 11 Year Data Set: Pulsar-timing constraints on the Stochastic Gravitational-wave Background
We search for an isotropic stochastic gravitational-wave background (GWB) in the newly released 11 year data set from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav). While we find no evidence for a GWB, we place constraints on a population of inspiraling supermassive…
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Buku
Anthropological Linguistics
This collection presents new research on key topics in anthropological linguistics, with a focus on African languages. While Africanist linguists have long been concerned with sociocultural aspects of language structure and use, no comprehensive volume dedicated to the anthropological linguistics…
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Integrating artificial intelligence and Internet of Things (IoT) for enhanced crop monitoring and management in precision agriculture
The integration of Artificial Intelligence (AI) and Internet of Things (IoT) technologies is transforming precision agriculture by enhancing crop monitoring and management. This review explores cutting-edge methodologies and innovations in modern agriculture, including high-throughput phenotyping…
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CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors
In the past decade, chimeric antigen receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach for combating cancers, demonstrating remarkable efficacy in relapsed/refractory hematological malignancies in both pediatric and adult patients. CAR-natural killer (CAR-NK) cell…
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JADES
Spectroscopy with the James Webb Space Telescope has opened the possibility of identifying moderate-luminosity active galactic nuclei (AGNs) in the early Universe, at and beyond the epoch of re-ionisation, complementing previous surveys of much more luminous (and much rarer) quasars. We present 12…
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Talking about Large Language Models
Interacting with a contemporary LLM-based conversational agent can create an illusion of being in the presence of a thinking creature. Yet, in their very nature, such systems are fundamentally not like us.
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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Abstract RAS oncogenes (collectively NRAS , HRAS and especially KRAS ) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 61 1 . Small molecule inhibitors of the KRAS(G12C) oncoprotein have demonstrated clinical efficacy in patients…
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Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes
BACKGROUND: The Canadian Network for Mood and Anxiety Treatments (CANMAT) last published clinical guidelines for the management of major depressive disorder (MDD) in 2016. Owing to advances in the field, an update was needed to incorporate new evidence and provide new and revised recommendations…
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Guidelines for minimal information on cellular senescence experimentation in vivo
Cellular senescence is a cell fate triggered in response to stress and is characterized by stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging from tissue repair to chronic disease. The development of new tools to study senescence in vivo has paved the way…
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The Pfam protein families database: embracing AI/ML
The Pfam protein families database is a comprehensive collection of protein domains and families used for genome annotation and protein structure and function analysis (https://www.ebi.ac.uk/interpro/). This update describes major developments in Pfam since 2020, including decommissioning the Pfam…
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Global burden of cancer and associated risk factors in 204 countries and territories, 1980–2021: a systematic analysis for the GBD 2021
BACKGROUND: Cancer is the second most common cause of death globally. Therefore, it is imperative to investigate cancer incidence, mortality rates, and disability-adjusted life years (DALYs) to enhance preventive measures and healthcare resource allocation. This study aimed to assess cancer burden…
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RETRACTED: Nanotechnology-enhanced fiber-reinforced polymer composites: Recent advancements on processing techniques and applications
Incorporating nanoparticles can significantly improve the performance and functionality of fiber-reinforced polymer (FRP) composites. Different techniques exist for processing, testing, and implementing nanocomposites in various industries. Depending on these factors, these materials can be…
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Healthcare on the brink: navigating the challenges of an aging society in the United States
The US healthcare system is at a crossroads. With an aging population requiring more care and a strained system facing workforce shortages, capacity issues, and fragmentation, innovative solutions and policy reforms are needed. This paper aims to spark dialogue and collaboration among healthcare…
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Language Difference in Writing: Toward a Translingual Approach
Growing numbers of U.S. teachers and scholars of writing recognize that traditional ways of understanding and responding to language differences are inadequate to the facts on the ground. Language use in our classrooms, our communities, the nation, and the world has always been multilingual rather…
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Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier
The blood-brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, the BBB also prevents the passage of various forms of therapeutic agents, nanocarriers, and their cargos. Recently, many…
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