79 hasil untuk "Akash Deep"
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Advanced financial market forecasting: integrating Monte Carlo simulations with ensemble Machine Learning models
This paper presents a novel integration of Machine Learning (ML) models with Monte Carlo simulations to enhance financial forecasting and risk assessments in dynamic market environments. Traditional financial forecasting methods, which primarily rely on linear statistical and econometric models…
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Genome-Wide Analysis of VILLIN Gene Family Associated with Stress Responses in Cotton (Gossypium spp.)
The VILLIN (VLN) protein plays a crucial role in regulating the actin cytoskeleton, which is involved in numerous developmental processes, and is crucial for plant responses to both biotic and abiotic factors. Although various plants have been studied to understand the VLN gene family and its…
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Use of terlipressin in critically ill children with liver disease
Abstract Background Terlipressin, a long-acting synthetic analogue of vasopressin has been used in the adult population for various indications including hepatorenal syndrome (HRS-AKI), esophageal variceal hemorrhage (EVH) and shock, but its use in pediatrics is still limited to individualized…
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Micronutrient needs in critically Ill children undergoing continuous renal replacement therapy and protein requirements in acute kidney injury patients
Nutrition is one of the cornerstones in the treatment and support of critically ill patients. Nutritional support includes the provision of calories, protein, electrolytes, vitamins, and trace elements through enteral or parenteral routes. Acute kidney injury (AKI) is a common problem in critically…
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High Water Density at Non-Ice-Binding Surfaces Contributes to the Hyperactivity of Antifreeze Proteins
[Image: see text] Antifreeze proteins (AFPs) can bind to ice nuclei thereby inhibiting their growth and their hydration shell is believed to play a fundamental role. Here, we use molecular dynamics simulations to characterize the hydration shell of four moderately-active and four hyperactive AFPs…
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Transport of critically sick children to transplant centres
Transport of a critically sick child can be a very challenging task. This requires close coordination between transport team, referring and receiving centers. In this review, we emphasize on children who are transported for transplant consideration to higher centers specifically liver, renal and…
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Computational analysis to study the effect of infusion of Tetracyanoquinodimethane in zinc based metal-organic framework
The present study reports the computational analysis of band structures and density of state (DOS) profiles of a Tetracyanoquinodimethane (TCNQ) infused IRMOF-1 (Iso Reticular Metal-Organic Framework-1). IRMOF-1 is a zinc-based MOF and has been reported useful in literature for a variety of…
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A Two-Year Experience of Gender-Based Violence at a Pioneer One Stop Crisis Center: Sukoon
This paper examines violence against women, with a special focus on domestic violence, along with sexual violence and sexual assault, in multidimensional perspective for the period of two years so as to understand its magnitude and its impact on the rights of women in the northern part of India…
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Analysis of L-DOPA and droxidopa binding to human β(2)-adrenergic receptor
Over the last two decades, an increasing number of studies has been devoted to a deeper understanding of the molecular process involved in the binding of various agonists and antagonists to active and inactive conformations of β(2)-adrenergic receptor (β(2)AR). The 3.2 Å x-ray crystal structure of…
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L-DOPA and Droxidopa: From Force Field Development to Molecular Docking into Human β(2)-Adrenergic Receptor
The increasing interest in the molecular mechanism of the binding of different agonists and antagonists to [Formula: see text] (2)-adrenergic receptor ([Formula: see text] (2)AR) inactive and active states has led us to investigate protein–ligand interactions using molecular docking calculations…
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On collaborative reinforcement learning to optimize the redistribution of critical medical supplies throughout the COVID-19 pandemic
OBJECTIVE: This work investigates how reinforcement learning and deep learning models can facilitate the near-optimal redistribution of medical equipment in order to bolster public health responses to future crises similar to the COVID-19 pandemic. MATERIALS AND METHODS: The system presented is…
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L-cysteine/MoS2 modified robust surface plasmon resonance optical fiber sensor for sensing of Ferritin and IgG
Abstract L-cysteine conjugated molybdenum disulphide (MoS2) nanosheets have been covalently attached to a gold coated surface plasmon resonance (SPR) optical fiber to prepare a robust and stable sensor. Owing to the multifunctionality of the deposited nanosheet conjugate, the antibodies are also…
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Nanotwinning: Generation, properties, and application
In recent years, nanotwinned (NT) materials have attracted great attention in several research areas because of many advantageous properties (e.g., high conductivity, excellent mechanical stability, and distinctive structure). This article explains the twin defects in the nano-regime based on an…
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Oxygen Delivery and Oxygen Consumption in Pediatric Fluid Refractory Septic Shock During the First 42 h of Therapy and Their Relationship to 28-Day Outcome
Background: In septic shock, both oxygen delivery (DO2) and oxygen consumption (VO2) are dysfunctional. The current therapeutic regimens are geared to normalize global oxygen delivery (DO2) to tissues via goal directed therapies but mortality remains high at 10–20%.Methods: We studied cardiac index…
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Acute liver failure in children - A constant challenge for the treating intensivist
Pediatric acute liver failure (ALF) is a rare complex clinical syndrome with a fatal outcome, if not diagnosed and treated at the right time. ALF in children can be difficult to recognize and is very different from ALF in adults; in terms of definition, etiology, symptomatology and management. The…
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Study of sexual assault cases among below 18 years age group during September 2018 to September 2020 in Government Medical College, Patiala, Punjab, India: cross-sectional study
INTRODUCTION: there are instances commonly reported where sexual offences are committed against persons below 18 years of age, who are deemed as children. The adverse effects of child sexual abuse are psychological, physical, behavioural and interpersonal. METHODS: this study was conducted in the…