69 hasil untuk "Alejandro Balsa"

Risk Factors for Developing Rheumatoid Arthritis in Patients With Undifferentiated Arthritis and Inflammatory Arthralgia

Marta Novella-Navarro; Chamaida Plasencia-Rodríguez; Laura Nuño dkk.

Frontiers in Medicine, Vol. 8 · 2021 · Inggris · DOAJ Scopus

Currently, there is an increasing interest in treating patients at risk of rheumatoid arthritis (RA) to prevent the development of this chronic disease. In this sense, research has focused attention on the early identification of predictive factors of this disease. Autoantibodies and markers of…

Validity of the EULAR recommendations on the use of ultrasound in the diagnosis of giant cell arteritis

Alejandro Balsa; Eugenio De Miguel; Diana Peiteado dkk.

RMD Open, Vol. 8 No. 1 · 2022 · Inggris · DOAJ Scopus

Methotrexate Reduces the Probability of Discontinuation of TNF Inhibitors in Seropositive Patients With Rheumatoid Arthritis. A Real-World Data Analysis

Borja Hernández-Breijo; Claudia M. Brenis; Chamaida Plasencia-Rodríguez dkk.

Frontiers in Medicine, Vol. 8 · 2021 · Inggris · DOAJ Scopus

Tumor necrosis factor inhibitors (TNFi) are widely used for the treatment of patients with rheumatoid arthritis (RA), however a considerable percentage of patients discontinued the therapy. The aim of this study is to explore real-world TNFi survival, stratified for seropositivity, and to determine…

Treat-To-Target and Treat-To-Budget in Rheumatoid Arthritis: Measuring the Value of Individual Therapeutic Interventions

José A. Sacristán; Silvia Díaz; Inmaculada de la Torre dkk.

Rheumatology and Therapy, Vol. 6 No. 4 · 2019 · Inggris · DOAJ Scopus

Abstract Treat-to-target (T2T) and dose tapering after obtaining the therapeutic objective (called “treat-to-budget”-T2B-in this Commentary) are the two most commonly used therapeutic strategies in rheumatoid arthritis. In theory, both strategies could add value to the healthcare system, although…

Persistence of biological agents over an eight-year period in rheumatoid arthritis and spondyloarthritis patients

María Ángeles González-Fernández; Elena Villamañán; Inmaculada Jiménez-Nácher dkk.

Farmacia Hospitalaria, Vol. 41 No. 3 · 2019 · Spanyol · DOAJ Scopus

Objective: To calculate the persistence, over a period of eight years, the retention rate of first and second-line of treatment with biological agents in patients with rheumatoid arthritis, spondyloarthritis and psoriatic arthritis and to compare retention rates of the various drugs for each…

Healthcare-related impact of gout in hospitalized patients in Spain

Diego Benavent; Diana Peiteado; María Ángeles Martinez-Huedo dkk.

Scientific Reports, Vol. 11 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract To analyze the epidemiology, clinical features and costs of hospitalized patients with gout during the last decade in Spain. Retrospective observational study based on data from the Minimum Basic Data Set (MBDS) from the Spanish National Health Service database. Patients ≥ 18 years with…

What have we learnt from the inhibition of IL-6 in RA and what are the clinical opportunities for patient outcomes?

Peter C. Taylor; Eugen Feist; Janet E. Pope dkk.

Therapeutic Advances in Musculoskeletal Disease, Vol. 16 · 2024 · Inggris · DOAJ Scopus

Rheumatoid arthritis (RA) is an autoimmune disease characterised by persistent inflammation of the synovial joints as well as other tissues and organs. Left untreated, it can lead to joint damage, disability and even increased mortality. The disease is driven by inflammatory cytokines that…

Axial spondyloarthritis and axial psoriatic arthritis: similar or different disease spectrum?

Diego Benavent; Chamaida Plasencia-Rodríguez; Karen Franco-Gómez dkk.

Therapeutic Advances in Musculoskeletal Disease, Vol. 12 · 2020 · Inggris · DOAJ Scopus

Aims: First, to compare clinical features and biological disease modifying anti-rheumatic drugs (bDMARDs) response in patients with axial spondyloarthritis (axSpA) and axial psoriatic arthritis (axPsA). Second, to identify possible predictors of treatment response in both entities. Methods…

Exosomal Protein Biomarkers in Arthritis: Deciphering the Inflammatory Profiles of RA and OA

Claudia M. Brenis Gómez; Chamaida Plasencia-Rodríguez; Marta Novella-Navarro dkk.

Biomedicines, Vol. 13 No. 6 · 2025 · Inggris · DOAJ Scopus

Background/Objectives: Rheumatoid arthritis (RA) and osteoarthritis (OA) are highly prevalent diseases and their pathophysiology, diagnosis and treatment continue to be challenging. The aim of this study was to characterize and differentiate the profiles of the serum extracellular vesicles (EVs)…

Frequency of Th17 CD4+ T Cells in Early Rheumatoid Arthritis: A Marker of Anti-CCP Seropositivity

Irene Arroyo-Villa; María-Belén Bautista-Caro; Alejandro Balsa dkk.

Public Library of Science · 2012 · Inggris · PLOS Scopus

Objective: To examine the frequency and phenotype of Th17 cells in the peripheral blood of early RA (eRA) patients. Methods: CD4+ T cells were isolated from the peripheral blood of 33 eRA patients, 20 established RA patients and 53 healthy controls (HC), and from the synovial fluid of 20…

Coping with rheumatic stressors (CORS) questionnaire: Spanish translation and cross-cultural adaptation

Diego Benavent; Andrea Jochems; Dora Pascual-Salcedo dkk.

Journal of Patient-Reported Outcomes, Vol. 7 No. 1 · 2023 · Inggris · DOAJ Scopus

Abstract Background Rheumatic and Musculoskeletal Diseases (RMDs) substantially impact the lives of patients, with complex associations between disease severity and self-perceived health status. In this regard, the Coping with Rheumatic Stressors (CORS) questionnaire was developed to measure how…

Comparison of long-term efficacy between biological agents following tumor necrosis factor inhibitor failure in patients with rheumatoid arthritis: a prospective cohort study

Patricia Bogas; Chamaida Plasencia-Rodriguez; Victoria Navarro-Compán dkk.

Therapeutic Advances in Musculoskeletal Disease, Vol. 13 · 2021 · Inggris · DOAJ Scopus

Background: Currently, there is contradictory evidence regarding the best strategy to follow after discontinuation of a first biological agent in patients with rheumatoid arthritis (RA). We aimed to compare the long-term efficacy of switching to a second tumor necrosis factor inhibitor (TNFi)…

Value of Measuring Anti-Carbamylated Protein Antibodies for Classification on Early Arthritis Patients

Cristina Regueiro; Laura Nuño; Ana M. Ortiz dkk.

Scientific Reports, Vol. 7 No. 1 · 2017 · Inggris · DOAJ Scopus

Abstract Classification of patients with rheumatoid arthritis (RA) as quickly as possible improves their prognosis. This reason motivates specially dedicated early arthritis (EA) clinics. Here, we have used 1062 EA patients with two years of follow-up to explore the value of anti-carbamylated…

The TT Genotype of the STAT4 rs7574865 Polymorphism Is Associated with High Disease Activity and Disability in Patients with Early Arthritis

Amalia Lamana; Alejandro Balsa; Blanca Rueda dkk.

Public Library of Science · 2012 · Inggris · PLOS Scopus

Background: The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis. In the present study, we investigated the effects of these genetic…

Monitoring chronic inflammatory musculoskeletal diseases mixing virtual and face-to-face assessments—Results of the digireuma study

Diego Benavent; Luis Fernández-Luque; Francisco J. Núñez-Benjumea dkk.

PLOS Digital Health, Vol. 1 No. 12 · 2022 · Inggris · PLOS Scopus

Mobile health technology holds great promise for the clinical management of patients with chronic disease. However, evidence on the implementation of projects involving digital health solutions in rheumatology is scarce. We aimed to study the feasibility of a hybrid (virtual and face-to-face)…

Improved RA classification among early arthritis patients with the concordant presence of three RA autoantibodies: analysis in two early arthritis clinics

Cristina Regueiro; Lorena Rodríguez-Martínez; Laura Nuño dkk.

Arthritis Research & Therapy, Vol. 21 No. 1 · 2019 · Inggris · DOAJ Scopus

Abstract Background The patients with RA benefit from early identification soon after the first clinical symptoms appear. The 2010 ACR/EULAR classification criteria were developed to fulfill this need and their application has been demonstrated to be effective. However, there is still room for…

Patient and physician assessment in difficult-to-treat rheumatoid arthritis: patterns of subjective perception at early stages of b/tsDMARD treatment

Alejandro Balsa; Laura Nuño; Diana Peiteado dkk.

RMD Open, Vol. 9 No. 3 · 2023 · Inggris · DOAJ Scopus

Objectives To analyse the trajectories of Disease Activity Score 28 (DAS28), patient global assessment (PGA) and physician global assessment (PhGA) and to assess their predictive capabilities on difficult-to-treat rheumatoid arthritis (D2TRA) classification.Methods Longitudinal study of patients…

Association of CD247 Polymorphisms with Rheumatoid Arthritis: A Replication Study and a Meta-Analysis

María Teruel; Cushla McKinney; Alejandro Balsa dkk.

PLoS ONE, Vol. 8 No. 7 · 2013 · Inggris · PLOS Scopus

Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537)…

Efficacy, safety and cost-effectiveness of a web-based platform delivering the results of a biomarker-based predictive model of biotherapy response for rheumatoid arthritis patients: a protocol for a randomized multicenter single-blind active controlled clinical trial (PREDIRA)

Dalifer Freites-Núñez; Athan Baillet; Luis Rodriguez-Rodriguez dkk.

Trials, Vol. 21 No. 1 · 2020 · Inggris · DOAJ Scopus

Abstract Background Rheumatoid arthritis (RA) is one of the leading chronic inflammatory rheumatism. First-line therapy with synthetic disease-modifying antirheumatic drugs (sDMARD) is insufficiently effective in 40% of cases and these patients are treated with biotherapies. The increased use of…

Effect of Filgotinib on Body Mass Index (BMI) and Effect of Baseline BMI on the Efficacy and Safety of Filgotinib in Rheumatoid Arthritis

Alejandro Balsa; Siegfried Wassenberg; Yoshiya Tanaka dkk.

Rheumatology and Therapy, Vol. 10 No. 6 · 2023 · Inggris · DOAJ Scopus

Abstract Introduction This post hoc analysis of the phase 3 rheumatoid arthritis (RA) filgotinib clinical trial program assessed the effect of filgotinib on body mass index (BMI) in patients with RA and the impact of BMI on the efficacy and safety of filgotinib. Methods FINCH 1–3 were randomized…