112 hasil untuk "Beth Stuart"
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Artikel Jurnal Teks lengkap
Asthma trajectories in early childhood: identifying modifiable factors.
BACKGROUND: There are conflicting views as to whether childhood wheezing represents several discreet entities or a single but variable disease. Classification has centered on phenotypes often derived using subjective criteria, small samples, and/or with little data for young children. This is…
Juga tersedia di: PLOS
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Artikel Jurnal
Clustering of continuous and binary outcomes at the general practice level in individually randomised studies in primary care - a review of 10 years of primary care trials
Abstract Background In randomised controlled trials, the assumption of independence of individual observations is fundamental to the design, analysis and interpretation of studies. However, in individually randomised trials in primary care, this assumption may be violated because patients are…
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Artikel Jurnal
Association of type 2 diabetes remission and risk of cardiovascular disease in pre‐defined subgroups
Abstract Aim To quantify the association between type 2 diabetes remission and 5‐year incidence of cardiovascular disease outcomes, overall and in pre‐defined subgroups. Methods Retrospective cohort analysis of 60,287 adults with type 2 diabetes from the Care and Health Information Analytics (CHIA)…
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Artikel Jurnal Teks lengkap
Risk factors for community-acquired respiratory infections in a non-pandemic context: Secondary analysis of the PRIMIT study.
ObjectivesRespiratory tract infection (RTI) incidence varies between people, but little is known about why. The aim of this study is therefore to identify risk factors for acquiring RTIs.MethodsWe conducted a secondary analysis of 16,908 participants in the PRIMIT study, a pre-pandemic randomised…
Juga tersedia di: PLOS
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Artikel Jurnal
Selective serotonin reuptake inhibitors (SSRIs) in women of reproductive age: a systematic review of local formularies
Background: Depression is the second most common chronic condition affecting women of reproductive age; 23.4% of women enter pregnancy with depression and use of selective serotonin reuptake inhibitors (SSRIs) in pregnancy is often necessary for maternal wellbeing. However, SSRI use during…
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Artikel Jurnal
A non-linear optimisation method to extract summary statistics from Kaplan-Meier survival plots using the published P value
Abstract Background Meta-analyses of studies evaluating survival (time-to-event) outcomes are a powerful technique to assess the strength of evidence for a given disease or treatment. However, these studies rely on the adequate reporting of summary statistics in the source articles to facilitate…
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Artikel Jurnal
Postal methods for monitoring HbA1c in diabetes mellitus: a protocol for systematic review
Background: Worldwide there are an estimated 463 million people with diabetes. In the UK people with diabetes are offered annual review, which includes monitoring of haemoglobin A1c (HbA1c). This can identify people with diabetes who are not meeting their glycaemic targets, enabling early…
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Artikel Jurnal
Determining the minimal important change of the recap of atopic eczema (RECAP) instrument in clinical trials
Abstract Background The Recap of atopic eczema (RECAP) is a patient‐reported instrument designed to assess eczema control. There is a lack of evidence on the interpretability of change scores in clinical trials. Objectives To calculate the smallest detectable change (SDC) in RECAP and estimate the…
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Artikel Jurnal
The role of parity in the relationship between endometriosis and pregnancy outcomes: a systematic review and meta-analysis
Endometriosis is a chronic and debilitating condition which can affect the entire reproductive life course of women with a potentially detrimental effect on pregnancy. Pregnancy (and increasing parity) can affect endometriosis by modulating disease severity and suppressing symptoms. Multiparous…
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Artikel Jurnal
Understanding GPs’ views and experiences of using clinical prediction rules in the management of respiratory infections: a qualitative study
Background: Respiratory tract infections (RTIs) account for 60% of antibiotic prescribing in primary care. Several clinical prediction rules (CPRs) have been developed to help reduce unnecessary prescribing for RTIs, but there is a lack of studies exploring whether or how these CPRs are being used…
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Artikel Jurnal
Planning and developing a web-based intervention for active surveillance in prostate cancer: an integrated self-care programme for managing psychological distress
Abstract Objectives To outline the planning, development and optimisation of a psycho-educational behavioural intervention for patients on active surveillance for prostate cancer. The intervention aimed to support men manage active surveillance-related psychological distress. Methods The…
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Artikel Jurnal
Type 2 diabetes remission trajectories and variation in risk of diabetes complications: A population-based cohort study.
Biochemical remission of type 2 diabetes is achievable through dietary changes, physical activity and subsequent weight loss. We aim to identify distinct diabetes remission trajectories in a large population-based cohort over seven-years follow-up and to examine associations between remission…
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Artikel Jurnal
Characterising cancer-associated fibroblast heterogeneity in non-small cell lung cancer: a systematic review and meta-analysis
Abstract Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with evidence suggesting they represent a heterogeneous population. This study summarises the prognostic role of all proteins characterised in CAFs with immunohistochemistry in non-small cell lung…
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Artikel Jurnal
Understanding Remission of Long-Term Conditions Through Electronic Health Records: Scoping Review
Abstract BackgroundMultiple long-term conditions (MLTCs) require complex and prolonged treatment regimens. Remission in long-term conditions (LTCs) is important for understanding disease progression and evaluating treatment effectiveness. Electronic health records (EHRs) are increasingly used to…