55 results for "Burkhard Ludewig"

Immunopathological Basis of Virus-induced Myocarditis

Reinhard Maier; Philippe Krebs; Burkhard Ludewig

Clinical and Developmental Immunology, Vol. 11 No. 1 · 2004 · English · DOAJ

Heart diseases are an important cause of morbidity and mortality in industrialized countries. Dilated cardiomyopathy (DCM), one of the most common heart diseases, may be the consequence of infectionassociated myocardits. Coxsackievirus B3 (CVB3) can be frequently detected in the inflamed heart…

Topological Structure and Robustness of the Lymph Node Conduit System

Mario Novkovic; Lucas Onder; Gennady Bocharov et al.

Cell Reports, Vol. 30 No. 3 · 2020 · English · DOAJ Scopus

Summary: Fibroblastic reticular cells (FRCs) form a road-like cellular network in lymph nodes (LNs) that provides essential chemotactic, survival, and regulatory signals for immune cells. While the topological characteristics of the FRC network have been elaborated, the network properties of the…

Integrative Computational Modeling of the Lymph Node Stromal Cell Landscape

Mario Novkovic; Lucas Onder; Hung-Wei Cheng et al.

Frontiers in Immunology, Vol. 9 · 2018 · English · DOAJ Scopus

Adaptive immune responses develop in secondary lymphoid organs such as lymph nodes (LNs) in a well-coordinated series of interactions between migrating immune cells and resident stromal cells. Although many processes that occur in LNs are well understood from an immunological point of view, our…

IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells

Lalit Kumar Dubey; Burkhard Ludewig; Sanjiv A. Luther et al.

Cell Reports, Vol. 27 No. 8 · 2019 · English · DOAJ Scopus

Summary: Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) require the interaction of follicle-associated CXCR5+ dendritic cells with naive T cells in the draining mesenteric lymph nodes (mLNs). However, the source of CXCL13 responsible for attracting…

Towards a Coronavirus-Based HIV Multigene Vaccine

Volker Thiel; Burkhard Ludewig; Klara K. Eriksson et al.

Clinical and Developmental Immunology, Vol. 13 No. 2-4 · 2006 · English · DOAJ

Fibroblasts as immune regulators in infection, inflammation and cancer

Sarah Davidson; Mark Coles; Tom Thomas et al.

Nature reviews. Immunology · 2021 · English · OpenAlex Scopus

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Lalit Kumar Dubey; Praneeth Karempudi; Sanjiv A. Luther et al.

Nature Communications, Vol. 8 No. 1 · 2017 · English · DOAJ Scopus

The growth of lymph nodes in response to infection requires lymphangiogenesis. Dubey et al. show that the mesenteric lymph node lymphangiogenesis upon helminth infection depends on the signaling loop between the B and fibroblastic reticular cells (FRCs), whereby the FRCs respond to lymphotoxin…

Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines

Roland Züst; Luisa Cervantes-Barragán; Thomas Kuri et al.

PLoS Pathogens, Vol. 3 No. 8 · 2007 · English · PLOS Scopus

Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the coding sequence of the non-structural protein 1 (nsp1). In cell culture, nsp1 of mouse hepatitis…

Also available at: DOAJ

The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells

Florian Mair; Stefanie Joller; Romy Hoeppli et al.

eLife, Vol. 4 · 2015 · English · DOAJ

γδ T cells contribute to first line immune defense, particularly through their ability for rapid production of proinflammatory cytokines. The cytokine profile of γδ T cells is hard-wired already during thymic development. Yet, the molecular pathways underlying this phenomenon are incompletely…

Editorial: Mathematical Modeling of the Immune System in Homeostasis, Infection and Disease

Gennady Bocharov; Vitaly Volpert; Burkhard Ludewig et al.

Frontiers in Immunology, Vol. 10 · 2020 · English · DOAJ Scopus

Dendritic Cell-Specific Delivery of Flt3L by Coronavirus Vectors Secures Induction of Therapeutic Antitumor Immunity

Christian Perez-Shibayama; Cristina Gil-Cruz; Monika Nussbacher et al.

PLoS ONE, Vol. 8 No. 11 · 2013 · English · PLOS Scopus

Efficacy of antitumor vaccination depends to a large extent on antigen targeting to dendritic cells (DCs). Here, we assessed antitumor immunity induced by attenuated coronavirus vectors which exclusively target DCs in vivo and express either lymphocyte- or DC-activating cytokines in combination…

Also available at: DOAJ

A Systems Immunology Approach to Plasmacytoid Dendritic Cell Function in Cytopathic Virus Infections

Gennady Bocharov; Roland Züst; Luisa Cervantes-Barragan et al.

PLoS Pathogens, Vol. 6 No. 7 · 2010 · English · PLOS Scopus

Plasmacytoid dendritic cell (pDC)-mediated protection against cytopathic virus infection involves various molecular, cellular, tissue-scale, and organism-scale events. In order to better understand such multiscale interactions, we have implemented a systems immunology approach focusing on the…

Also available at: DOAJ

Evolution of Salmonella Typhi outer membrane protein-specific T and B cell responses in humans following oral Ty21a vaccination: A randomized clinical trial

Juan Manuel Carreño; Christian Perez-Shibayama; Cristina Gil-Cruz et al.

PLOS ONE, Vol. 12 No. 6 · 2017 · English · PLOS Scopus

Vaccination against complex pathogens such as typhoidal and non-typhoidal Salmonella requires the concerted action of different immune effector mechanisms. Outer membrane proteins (Omps) of Salmonella Typhi are potent immunogens, which elicit long-lasting and protective immunity. Here, we followed…

Heterologous Prime Boost Vaccination Induces Protective Melanoma-Specific CD8+ T Cell Responses

Sandra S. Ring; Michał Królik; Fabienne Hartmann et al.

Molecular Therapy: Oncolytics, Vol. 19 · 2020 · English · DOAJ

Cancer vaccination aims at inducing an adaptive immune response against tumor-derived antigens. In this study, we utilize recombinant human adenovirus serotype 5 (rAd5) and recombinant lymphocytic choriomeningitis virus (rLCMV)-based vectors expressing the melanocyte differentiation antigen gp100…

HDAC1 Controls CD8 + T Cell Homeostasis and Antiviral Response

Roland Tschismarov; Sonja Firner; Cristina Gil-Cruz et al.

PLoS ONE, Vol. 9 No. 10 · 2014 · English · PLOS Scopus

Reversible lysine acetylation plays an important role in the regulation of T cell responses. HDAC1 has been shown to control peripheral T helper cells, however the role of HDAC1 in CD8+ T cell function remains elusive. By using conditional gene targeting approaches, we show that LckCre-mediated…

Also available at: DOAJ

Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection

Lalit Kumar Dubey; Luc Lebon; Ilaria Mosconi et al.

Cell Reports, Vol. 15 No. 7 · 2016 · English · DOAJ Scopus

Summary: Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune responses and undergo a remarkable expansion in response to inflammatory stimuli. Although the formation of B cell follicles was previously thought to be restricted to the postnatal period, we…