26 results for "Ching-Chun Lin"

Association between parabens exposure and neurodevelopment in children

Chia-Jung Tung; Mei-Huei Chen; Ching-Chun Lin et al.

Environment International, Vol. 188 · 2024 · English · DOAJ Scopus

Objective: Parabens are a group of substances commonly employed as antimicrobial preservatives. The effect of parabens on the development of neurotoxicity in children is still controversial. This study aimed to explore the associations between parabens exposure and children's neurodevelopmental…

Antioxidant and Neuroproliferative Effects of THL-3-PTD5 Peptide Derived from Hydramacin-1 Antimicrobial Peptide

Ping-Chien Lee; Ching-Chun Lin; Hui-Hsuan Hsu et al.

Journal of Chemistry, Vol. 2024 · 2024 · English · DOAJ Scopus

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by reduced dopamine levels in the brain, affecting over 6 million people worldwide. While current treatments for patients primarily focus on symptom relief, there is a necessity for the development of novel therapeutic agents…

Characteristics and long-term outcomes of children with perianal Crohn’s disease

Ching-Chun Lin; Ichiro Takeuchi; Hirotaka Shimizu et al.

Intestinal Research, Vol. 24 No. 1 · 2026 · English · DOAJ Scopus

Background/Aims The incidence of perianal lesions (PL) in children with Crohn’s disease (CD) is higher in East Asia than in Western countries. Early intervention for PL is essential to prevent sphincter dysfunction and ostomy placement. In this study, we aimed to investigate the clinical features…

Laboratory cultivated Cordyceps militaris modulates cockroach allergen-induced inflammation in keratinocytes and macrophages dual cell platforms

Mey-Fann Lee; Jane-Yii Wu; Chi-Sheng Wu et al.

BMC Complementary Medicine and Therapies, Vol. 25 No. 1 · 2025 · English · DOAJ Scopus

Abstract Background Cordyceps militaris (CM) is noted for its anti-inflammatory properties and potential efficacy in treating allergic diseases. This research aimed to investigate the anti-inflammatory effect of ethanolic and aqueous extracts from laboratory-cultivated specific Cordyceps militaris…

Zolpidem Use and the Risk of Injury: A Population-Based Follow-Up Study.

Shiu-Dong Chung; Ching-Chun Lin; Li-Hsuan Wang et al.

PLoS ONE, Vol. 8 No. 6 · 2013 · English · DOAJ Scopus

BackgroundWhile an association between zolpidem use and fracture and road accident was previously proposed, this study aimed to further explore the frequency and risk of a wide spectrum of injuries in subjects prescribed with zolpidem in Taiwan.MethodsWe identified 77,036 subjects who received…

Also available at: PLOS

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

Shiu-Dong Chung; Shih-Ping Liu; Ching-Chun Lin et al.

PLoS ONE, Vol. 8 No. 8 · 2013 · English · DOAJ Scopus

BackgroundAlthough the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC) is still unclear, a common theme with BPS/IC patients is comorbid disorders which are related to the autonomic nervous system that connects the nervous system to end-organs. Nevertheless, no study to date has…

Also available at: PLOS

Association between schizophrenia and urinary calculi: a population-based case-control study.

Shih-Ping Liu; Ching-Chun Lin; Herng-Ching Lin et al.

PLoS ONE, Vol. 8 No. 3 · 2013 · English · DOAJ Scopus

BackgroundPeople with schizophrenia have been demonstrated to have higher overall morbidity and all-cause mortality rates from general medical conditions. However, little attention has been given to the urinary system of people with schizophrenia. As no direct evidence has been reported…

Also available at: PLOS

Increased Risk of Ischemic Stroke Among Women With Bladder Pain Syndrome/Interstitial Cystitis: A Cohort Study From Taiwan

Shiu-Dong Chung; Sudha Xirasagar; Ching-Chun Lin et al.

Urological Science, Vol. 26 No. 2 · 2015 · English · DOAJ Scopus

Increased Healthcare Service Utilizations for Patients with Dementia: A Population-Based Study

Shiu-Dong Chung; Shih-Ping Liu; Jau-Jiuan Sheu et al.

PLoS ONE, Vol. 9 No. 8 · 2014 · English · PLOS Scopus

Background: The majority of previous studies investigating the health care utilization of people with dementia were conducted in Western societies. There is little information on the economic burden on the healthcare system attributable to dementia in Asian countries. This study thus investigated…

Also available at: DOAJ

Enhanced home palliative care could reduce emergency department visits due to non-organic dyspnea among cancer patients: a retrospective cohort study

Hua-Shui Hsu; Tai-Hsien Wu; Chin-Yu Lin et al.

BMC Palliative Care, Vol. 20 No. 1 · 2021 · English · DOAJ Scopus

Abstract Background Dyspnea is a common trigger of emergency department visits among terminally ill and cancer patients. Frequent emergency department (ED) visits at the end of life are an indicator of poor-quality care. We examined emergency department visit rates due to dyspnea symptoms among…

Pardaxin, a Fish Antimicrobial Peptide, Exhibits Antitumor Activity toward Murine Fibrosarcoma <em>in Vitro</em> and <em>in Vivo</em><em></em>

Cho-Fat Hui; Cheng-Hui Lin; Ching-Chun Lin et al.

Marine Drugs, Vol. 10 No. 8 · 2012 · English · DOAJ Scopus

The antitumor activity of pardaxin, a fish antimicrobial peptide, has not been previously examined in <em>in vitro</em> and <em>in vivo </em>systems for treating murine fibrosarcoma. In this study, the antitumor activity of synthetic pardaxin was tested using murine MN-11 tumor cells as the study…

Impact of rapid temperature fluctuations on acute stroke risk: a nationwide case-crossover study from 2001 to 2020Research in context

Miku Kono; Wei-Te Wu; Chuan-Pin Lee et al.

The Lancet Regional Health. Western Pacific, Vol. 57 · 2025 · English · DOAJ Scopus

Summary: Background: Climate factors greatly affect cardiovascular health, with stroke ranking among serious global concerns. However, the impact of rapid temperature fluctuations on stroke risk remains underexplored. Given Taiwan's aging population and the intensifying effects of climate change…

Clinical and Metabolic Characteristics of Hyperuricemia with Risk of Liver Fibrosis: A Cross-Sectional Study

Chun-Yi Wang; Hsiang-Han Kao; Kuan-Yu Lai et al.

Metabolites, Vol. 12 No. 10 · 2022 · English · DOAJ Scopus

The role of serum uric acid (SUA) in the role of advanced fibrosis is not fully explored. The study assesses the risk of advanced fibrosis according to SUA in an Asian population with a total of 3612 subjects enrolled in one health management center between 2006 and 2008. The fibrosis-4 score was…

Stage-Specific Expression of TNFα Regulates Bad/Bid-Mediated Apoptosis and RIP1/ROS-Mediated Secondary Necrosis in Birnavirus-Infected Fish Cells

Wei-Lun Wang; Jiann-Ruey Hong; Gen-Hwa Lin et al.

PLoS ONE, Vol. 6 No. 2 · 2011 · English · PLOS Scopus

Infectious pancreatic necrosis virus (IPNV) can induce Bad-mediated apoptosis followed by secondary necrosis in fish cells, but it is not known how these two types of cell death are regulated by IPNV. We found that IPNV infection can regulate Bad/Bid-mediated apoptotic and Rip1/ROS-mediated…

Also available at: DOAJ

Validating psychometric properties of generic quality-of-life instruments (WHOQOL-BREF (TW) and EQ-5D) among non-dialysis chronic kidney disease: Rasch and confirmatory factor analyses

Chih-Hen Yu; Ching-Chun Lin; Zheng-Zhe Wu et al.

Journal of the Formosan Medical Association, Vol. 124 No. 6 · 2025 · English · DOAJ Scopus

Background: Quality of life (QOL) is important for evaluating medical care outcomes. In chronic kidney disease (CKD) population, generic instruments, such as WHOQOL-BREF and EQ-5D, are commonly used for comparing various medical conditions for policy-making purposes. However, their psychometric…