5 hasil untuk "Christin Müller-Ruttloff"
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Artikel Jurnal
Behind the membranous curtain—lipid dynamics and functions in coronaviral replication
ABSTRACT Lipids are naturally occurring hydrophobic biomolecules characterized by remarkable structural diversity. This includes various types of head groups, varying fatty acid chain lengths, degrees of unsaturation, and stereochemical configurations. Such variability enables lipids to serve…
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Artikel Jurnal
Targeting sphingolipid metabolism: inhibition of neutral sphingomyelinase 2 impairs coronaviral replication organelle formation
ABSTRACT Many plus-strand RNA viruses, including coronaviruses, orchestrate the formation of specialized replication organelles in the cytoplasm of infected cells by specific membrane-associated viral nonstructural proteins (nsp’s). This process involves a massive reorganization of intracellular…
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Artikel Jurnal
Potent anti-coronaviral activity of pateamines and new insights into their mode of action
Pateamines, derived from the sponge Mycale hentscheli, function as inhibitors of the RNA helicase eIF4A and exhibit promising antiviral and anticancer properties. eIF4A plays a pivotal role in unwinding stable RNA structures within the 5′-UTR of selected mRNAs, facilitating the binding of the 43S…
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Artikel Jurnal
Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients
IntroductionInfluenza A virus (IAV) infection can cause the often-lethal acute respiratory distress syndrome (ARDS) of the lung. Concomitantly, acute kidney injury (AKI) is frequently noticed during IAV infection, correlating with an increased mortality. The aim of this study was to elucidate the…
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Artikel Jurnal
RAAS antagonists dampen the SARS-CoV-2 infection in ex-vivo cultured human precision-cut lung slices
Abstract Background While the renin-angiotensin-aldosterone system (RAAS) is critically involved in pathomechanisms related to SARS-CoV-2 infection, the role of ongoing therapy with angiotensin-converting enzyme 1 inhibitors (ACEi) or Angiotensin-II type 1 receptor (AT1R) blockers (ARB) is much…