39 hasil untuk "Christopher Power"

An Integrated Strategy to Treat and Control Acid Mine Drainage from Waste Rock and Underground Workings at the Former Franklin Mine in Nova Scotia, Canada: Field Performance Monitoring

Christopher Power

Pollutants, Vol. 5 No. 1 · 2025 · Inggris · DOAJ Scopus

Acid mine drainage (AMD), which is primarily caused by the exposure of sulfidic minerals to oxygen and water during mining operations, remains a significant contributor to environmental pollution. Numerous technologies have been developed to prevent/control and treat AMD, including the isolation of…

Regulation of neural cell survival by HIV-1 infection

Gareth Jones; Christopher Power

Neurobiology of Disease, Vol. 21 No. 1 · 2006 · Inggris · DOAJ Scopus

Infection by the lentivirus, human immunodeficiency virus type 1 (HIV-1), results in a variety of syndromes involving both the central (CNS) and the peripheral (PNS) nervous systems. Productive HIV-1 infection of the CNS is chiefly detectable in perivascular macrophages and microglia. HIV-1 encoded…

Evolution of Acid Mine Drainage from a Coal Waste Rock Pile Reclaimed with a Simple Soil Cover

Murugan Ramasamy; Christopher Power

Hydrology, Vol. 6 No. 4 · 2019 · Inggris · DOAJ Scopus

Waste rock piles (WRPs) are commonly remediated with cover systems to limit water and oxygen influx and mitigate the impacts of acid mine drainage (AMD) on the environment. While numerous types of cover systems exist, simple, single-layer soil covers remain an attractive option due to their low…

Peroxisomes as emerging clinical targets in neuroinflammatory diseases

Andrej Roczkowsky; Richard A. Rachubinski; Tom C. Hobman dkk.

Frontiers in Molecular Neuroscience, Vol. 18 · 2025 · Inggris · DOAJ Scopus

Peroxisomes are membrane-bounded organelles that contribute to a range of physiological functions in eukaryotic cells. In the central nervous system (CNS), peroxisomes are implicated in several vital homeostatic functions including, but not limited to, reactive oxygen species signaling and…

MicroRNA-181 Variants Regulate T Cell Phenotype in the Context of Autoimmune Neuroinflammation

Samira Ghorbani; Farideh Talebi; Wing Fuk Chan dkk.

Frontiers in Immunology, Vol. 8 · 2017 · Inggris · DOAJ Scopus

BackgroundRecent studies have revealed that multiple sclerosis (MS) lesions have distinct microRNA (miRNA) expression profiles. miR-181 family members show altered expression in MS tissues although their participation in MS pathogenesis remains uncertain. Herein, we investigated the involvement of…

Potential for Shoreline Recession to Accelerate Discharge of Groundwater Pollutants to Coastal Waters

Sabina Rakhimbekova; Christopher Power; Denis M. O’Carroll dkk.

Water Resources Research, Vol. 59 No. 6 · 2023 · Inggris · DOAJ Scopus

Abstract Discharge of groundwater‐derived pollutants to inland and marine coastal waters is influenced by the transport and reactive processes occurring in nearshore aquifers. The effect of shoreline change on these processes and subsequent discharge of pollutants to coastal waters is unclear. The…

Is the Central Nervous System Reservoir a Hurdle for an HIV Cure?

Nazanin Mohammadzadeh; Nicolas Chomont; Jerome Estaquier dkk.

Viruses, Vol. 15 No. 12 · 2023 · Inggris · DOAJ Scopus

There is currently no cure for HIV infection although adherence to effective antiretroviral therapy (ART) suppresses replication of the virus in blood, increases CD4+ T-cell counts, reverses immunodeficiency, and increases life expectancy. Despite these substantial advances, ART is a lifelong…

Anti-inflammatory effects of moxifloxacin and levofloxacin on cadmium-activated human astrocytes: Inhibition of proinflammatory cytokine release, TLR4/STAT3, and ERK/NF-κB signaling pathway.

Suttinee Phuagkhaopong; Jidapha Sukwattanasombat; Kran Suknuntha dkk.

PLoS ONE, Vol. 20 No. 1 · 2025 · Inggris · DOAJ Scopus

Cadmium is a non-essential element and neurotoxin that causes neuroinflammation, which leads to neurodegenerative diseases and brain cancer. To date, there are no specific or effective therapeutic agents to control inflammation and alleviate cadmium-induced progressive destruction of brain cells…

Juga tersedia di: DOAJ, PLOS

The HIV-1 Accessory Protein Vpu Downregulates Peroxisome Biogenesis

Zaikun Xu; Robert Lodge; Christopher Power dkk.

mBio, Vol. 11 No. 2 · 2020 · Inggris · DOAJ Scopus

ABSTRACT Human immunodeficiency virus type 1 (HIV-1) establishes lifelong infections in humans, a process that relies on its ability to thwart innate and adaptive immune defenses of the host. Recently, we reported that HIV-1 infection results in a dramatic reduction of the cellular peroxisome pool…

Interplay between Zika Virus and Peroxisomes during Infection

Cheung Pang Wong; Zaikun Xu; Shangmei Hou dkk.

Cells, Vol. 8 No. 7 · 2019 · Inggris · DOAJ Scopus

Zika virus (ZIKV) has emerged as an important human pathogen that can cause congenital defects in the fetus and neurological conditions in adults. The interferon (IFN) system has proven crucial in restricting ZIKV replication and pathogenesis. The canonical IFN response is triggered by the…

Age- and disease-dependent HERV-W envelope allelic variation in brain: association with neuroimmune gene expression.

Rakesh K Bhat; Kristofor K Ellestad; B Matt Wheatley dkk.

PLoS ONE, Vol. 6 No. 4 · 2011 · Inggris · DOAJ Scopus

BACKGROUND: The glycoprotein, Syncytin-1, is encoded by a human endogenous retrovirus (HERV)-W env gene and is capable of inducing neuroinflammation. The specific allele(s) responsible for Syncytin-1 expression in the brain is uncertain. Herein, HERV-W env diversity together with Syncytin-1…

Juga tersedia di: PLOS

MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology.

Zaikun Xu; Eugene L Asahchop; William G Branton dkk.

PLoS Pathogens, Vol. 13 No. 6 · 2017 · Inggris · DOAJ Scopus

HIV-associated neurocognitive disorders (HAND) represent a spectrum neurological syndrome that affects up to 25% of patients with HIV/AIDS. Multiple pathogenic mechanisms contribute to the development of HAND symptoms including chronic neuroinflammation and neurodegeneration. Among the factors…

Juga tersedia di: PLOS

Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis

Brienne A. McKenzie; Jason P. Fernandes; Matthew A. L. Doan dkk.

Journal of Neuroinflammation, Vol. 17 No. 1 · 2020 · Inggris · DOAJ Scopus

Abstract Background Pyroptosis is a type of proinflammatory regulated cell death (RCD) in which caspase-1 proteolytically cleaves gasdermin D (GSDMD) to yield a cytotoxic pore-forming protein. Recent studies have suggested that additional cell death pathways may interact with GSDMD under certain…

Sparse Multicategory Generalized Distance Weighted Discrimination in Ultra-High Dimensions

Tong Su; Yafei Wang; Yi Liu dkk.

Entropy, Vol. 22 No. 11 · 2020 · Inggris · DOAJ Scopus

Distance weighted discrimination (DWD) is an appealing classification method that is capable of overcoming data piling problems in high-dimensional settings. Especially when various sparsity structures are assumed in these settings, variable selection in multicategory classification poses great…

A Comprehensive Resource Assessment for Wind Power Generation on the Rural Island of Sibuyan, Philippines

Jerome G. Gacu; Junrey D. Garcia; Eddie G. Fetalvero dkk.

Energies, Vol. 17 No. 9 · 2024 · Inggris · DOAJ Scopus

Amid rising energy demands in rural areas, thorough resource assessments for initiatives such as wind power are crucial. This study involves a land resource assessment for wind power generation on the rustic Sibuyan Island in the Philippines, which is currently experiencing an electricity shortage…

Human Endogenous Retrovirus-K(II) Envelope Induction Protects Neurons during HIV/AIDS

Rakesh K. Bhat; Wallis Rudnick; Joseph M. Antony dkk.

PLoS ONE, Vol. 9 No. 7 · 2014 · Inggris · PLOS Scopus

Human endogenous retroviruses (HERVs) are differentially expressed depending on the cell type and physiological circumstances. HERV-K has been implicated in the pathogenesis of several diseases although the functional consequences of its expression remain unknown. Human immunodeficiency virus (HIV)…