43 hasil untuk "Cosimo Bruni"

The burning question: To use or not to use cyclophosphamide in systemic sclerosis

Cosimo Bruni; Daniel E. Furst

European Journal of Rheumatology, Vol. 7 No. -3 · 2020 · Inggris · DOAJ

Open questions on the management of targeted therapies for the treatment of systemic sclerosis-interstitial lung disease: results of a EUSTAR survey based on a systemic literature review

Corrado Campochiaro; Maria Grazia Lazzaroni; Cosimo Bruni dkk.

Therapeutic Advances in Musculoskeletal Disease, Vol. 14 · 2022 · Inggris · DOAJ Scopus

Background: The results of randomized controlled (RCT) and retrospective studies have expanded the armamentarium of drugs for systemic sclerosis (SSc) – interstitial lung disease (ILD) treatment. The correct positioning of these drugs is not yet clarified. Objectives: Systemic literature review…

Sex differences in systemic sclerosis: from pathogenesis to clinical manifestations and treatment

Melpomeni Toitou; Maria Iacovantuono; Gesa Sauer dkk.

Therapeutic Advances in Musculoskeletal Disease, Vol. 17 · 2025 · Inggris · DOAJ Scopus

Systemic sclerosis (SSc) exhibits sex-related disparities in prevalence, clinical features, and outcomes. While women are more frequently affected, men often experience a more severe disease course, including diffuse cutaneous involvement, interstitial lung disease, and reduced survival. These…

The emerging role of lung ultrasound in COVID-19 pneumonia

Gemma Lepri; Martina Orlandi; Chiara Lazzeri dkk.

European Journal of Rheumatology, Vol. 7 No. -2 · 2020 · Inggris · DOAJ

The need for a holistic approach for SSc-ILD – achievements and ambiguity in a devastating disease

Anna-Maria Hoffmann-Vold; Yannick Allanore; Elisabeth Bendstrup dkk.

Respiratory Research, Vol. 21 No. 1 · 2020 · Inggris · DOAJ Scopus

Abstract Systemic sclerosis (SSc) is a multi-organ autoimmune disease with complex interactions between immune-mediated inflammatory processes and vascular pathology leading to small vessel obliteration, promoting uncontrolled fibrosis of skin and internal organs. Interstitial lung disease (ILD) is…

The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event?

Marco Matucci-Cerinic; Mirko Manetti; Cosimo Bruni dkk.

Arthritis Research & Therapy, Vol. 19 No. 1 · 2017 · Inggris · DOAJ Scopus

Abstract Systemic sclerosis is considered a disease dominated by a “loss of angiogenesis”, although in its early phases evidence indicates a disturbed angiogenic response only. In fact, microvascular changes are primarily due to endothelial cell injury, triggering downstream significant enlargement…

Switching from rituximab originator to GP2013 or CT-P10 biosimilars in autoimmune rheumatic diseases: drug retention rate and safety data from a multicentric retrospective cohort

Stefano Gentileschi; Cosimo Bruni; Carla Gaggiano dkk.

Therapeutic Advances in Musculoskeletal Disease, Vol. 16 · 2024 · Inggris · DOAJ Scopus

Background: Real-world evidence supporting a safe and effective transition from rituximab originator (RTX-O) to its biosimilars (RTX-B) in autoimmune rheumatic diseases (ARDs) is still limited. Objectives: The primary aims of this study were to evaluate the long-term persistence of RTX-B after the…

The Treatment of Lung Involvement in Systemic Sclerosis

Barbara Ruaro; Marco Confalonieri; Marco Matucci-Cerinic dkk.

Pharmaceuticals, Vol. 14 No. 2 · 2021 · Inggris · DOAJ Scopus

Systemic sclerosis (SSc) patients are often affected by interstitial lung disease (ILD) and, although there have been recent treatment advances, it remains the leading cause of death among SSc, with a 10-year mortality up to 40%. African Americans and subjects with diffuse cutaneous SSc or…

Opportunities and Limitations in Recycling Fossil Polymers from Textiles

Sabrina Bianchi; Flavia Bartoli; Cosimo Bruni dkk.

Macromol, Vol. 3 No. 2 · 2023 · Inggris · DOAJ Scopus

The recovery and recycling of textile waste is becoming urgent since textiles are generating more and more waste. In one year, about 92 million tons of textile waste are produced and the fashion industry accounts for 58 million tons of plastic waste per year. Several different synthetic fibres are…

Laser Speckle Contrast Analysis: Functional Evaluation of Microvascular Damage in Connective Tissue Diseases. Is There Evidence of Correlations With Organ Involvement, Such as Pulmonary Damage?

Barbara Ruaro; Cosimo Bruni; Barbara Wade dkk.

Frontiers in Physiology, Vol. 12 · 2021 · Inggris · DOAJ Scopus

Laser speckle contrast analysis (LASCA) is a non-contact technique able to quantify peripheral blood perfusion (PBP) over large skin areas. LASCA has been used to study hand PBP in several clinical conditions. These include systemic sclerosis (SSc) and systemic lupus erythematosus (SLE) and LASCA…

The Relationship between Pulmonary Damage and Peripheral Vascular Manifestations in Systemic Sclerosis Patients

Barbara Ruaro; Marco Confalonieri; Francesco Salton dkk.

Pharmaceuticals, Vol. 14 No. 5 · 2021 · Inggris · DOAJ Scopus

Systemic sclerosis (SSc) is an autoimmune disease, characterized by the presence of generalized vasculopathy and tissue fibrosis. Collagen vascular disorder in SSc is due to fibroblast and endothelial cell dysfunctions. This leads to collagen overproduction, vascular impairment and immune system…

What Role Does Trabecular Bone Score Play in Chronic Inflammatory Rheumatic Diseases?

Barbara Ruaro; Andrea Casabella; Luigi Molfetta dkk.

Frontiers in Medicine, Vol. 7 · 2020 · Inggris · DOAJ Scopus

Patients suffering from rheumatic inflammatory diseases, e.g., systemic sclerosis, rheumatoid arthritis, and ankylosing spondylitis, are at risk of low bone mass. Dual-energy X-ray Absorptiometry (DXA) is the traditional radiological measurement technique for bone mineral density (BMD). The…

Baricitinib in the treatment of rheumatoid arthritis: clinical and ultrasound evaluation of a real-life single-centre experience

Giulia Tesei; Laura Cometi; Francesca Nacci dkk.

Therapeutic Advances in Musculoskeletal Disease, Vol. 13 · 2021 · Inggris · DOAJ Scopus

Background: Ultrasound (US) is useful in monitoring RA patients, with the US7 score allowing grey-scale and power-Doppler (PD) semi-quantitative evaluation of synovitis and teno-synovitis. We evaluated real-life efficacy and safety of Baricitinib, an oral selective JAK1-2 inhibitor, in RA patients…

The Role of Bronchoalveolar Lavage in Systemic Sclerosis Interstitial Lung Disease: A Systematic Literature Review

Martina Orlandi; Laura Antonia Meliante; Arianna Damiani dkk.

Pharmaceuticals, Vol. 15 No. 12 · 2022 · Inggris · DOAJ Scopus

The role of Bronchoalveolar Lavage (BAL) in the evaluation of systemic sclerosis (SSc) interstitial lung disease (ILD) is still controversial. The aim of this systematic literature review was to investigate the use of BAL in SSc-ILD, and to focus on the pros and cons of its real-life application…

Combination of denosumab and biologic DMARDs in inflammatory muscle-skeletal diseases and connective tissue diseases

Cosimo Bruni; Cosimo Cigolini; Giulia Tesei dkk.

European Journal of Rheumatology, Vol. 8 No. 4 · 2021 · Inggris · DOAJ

Computed Tomography Predictors of Mortality or Disease Progression in Systemic Sclerosis–Interstitial Lung Disease: A Systematic Review

Nicholas Landini; Martina Orlandi; Cosimo Bruni dkk.

Frontiers in Medicine, Vol. 8 · 2022 · Inggris · DOAJ Scopus

ObjectiveAlthough interstitial lung disease (ILD) is a major cause of morbidity and mortality in systemic sclerosis (SSc), its prognostication remains challenging. Given that CT represents the gold standard imaging technique in ILD assessment, a systematic review on chest CT findings as predictors…

Does therapy with immunosuppressive drugs improve gastrointestinal symptoms in patients with systemic sclerosis?

Oliver Distler; Cosimo Bruni; Suzana Jordan dkk.

RMD Open, Vol. 10 No. 3 · 2024 · Inggris · DOAJ Scopus

Objectives While important progress was made regarding the treatment of systemic sclerosis (SSc), there is still no evidence-based disease-modifying treatment available for SSc-related gastrointestinal (GI) manifestations. We aimed to identify an association between immunosuppressive therapy and…

Interleukin-1 and Systemic Sclerosis: Getting to the Heart of Cardiac Involvement

Giacomo De Luca; Giulio Cavalli; Corrado Campochiaro dkk.

Frontiers in Immunology, Vol. 12 · 2021 · Inggris · DOAJ Scopus

Systemic sclerosis (SSc) is rare, severe connective tissue disease characterized by endothelial and vascular damage, immune activation, and resulting in inflammation and fibrosis of skin and internal organs, including the heart. SSc is associated with high morbidity and mortality. Cardiac…

Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis

Cosimo Bruni; Lavinia Mattolini; Lorenzo Tofani dkk.

Diagnostics, Vol. 12 No. 7 · 2022 · Inggris · DOAJ Scopus

Background: Chest computed tomography (CT) is the gold standard for the evaluation of systemic sclerosis-related interstitial lung disease (SSc-ILD). Lung ultrasound (LUS) is a radiation-free tool that identifies the B-lines as a main feature of ILD. We aimed to investigate the role of LUS in the…

Heterogeneity of determining disease severity, clinical course and outcomes in systemic sclerosis-associated interstitial lung disease: a systematic literature review

Marco Matucci-Cerinic; Oliver Distler; Cosimo Bruni dkk.

RMD Open, Vol. 9 No. 4 · 2023 · Inggris · DOAJ Scopus

Objective The course of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is highly variable and different from continuously progressive idiopathic pulmonary fibrosis (IPF). Most proposed definitions of progressive pulmonary fibrosis or SSc-ILD severity are based on the research…