16 results for "Francesca Perrone"
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Journal Article
From Landscape As Collective Asset To The Ecomuseum As Instrument Of Territorial Valorisation Comparative Experiences Of Diffuse Cultural Heritage Regeneration
The European Landscape Convention (Florence, 2000) marked an epistemological change shift in the concept of heritage, redefining it as a collective asset and a site for identity-forming practices. Despite growing scholarly interest in ecomuseums as participatory heritage tools, the literature lacks…
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Cultural Heritage Recognition through Protection of Historical Value and Urban Regeneration: CSOA Forte Prenestino
The conformation and dynamics of metropolitanisation act as propulsive elements of territorial transformations. The deficiency of infrastructural equipment, the heterogeneity of urban fabric and the lack of services and public spaces contribute to severing the identity ties between settled…
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Planning for sustainable tourism in protected areas. A policy-oriented spatial evaluation framework
The governance of protected areas plays a key role in preserving biodiversity and fostering sustainable development, particularly through nature-based tourism. This paper introduces the Robustness Supply Tourism Index (RSTI), a robust tool to assess the infrastructural balance of tourism…
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Heritage-Led Urban Regeneration in Rome: Recontextualising the Campo Trincerato through Network Strategies
Contemporary peri-urban landscapes face fragmentation, marginalisation, and the neglect of widespread cultural heritage. This article explores heritage-led regeneration as a strategic framework to revitalise marginal areas by focusing on the Campo Trincerato in Rome, a system of fifteen forts and…
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Una metodologia analitica applicata alla razionalizzazione dei servizi urbani in aree pedemontane Ottimizzazione dei servizi primari nel Comune di Tivoli
One of the main debate topics between citizens and people who manage public property is urban quality of life. The project aims to evaluate the spatial distribution of basic primary services (such as pharmacies, doctors' offices and shops that sell all the basic necessities) concerning people with…
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Planning for Just Cities with Nature-Based Solutions: Sustainability and Socio-Environmental Inequalities in San José de Chamanga, Ecuador
Self-constructed cities refer to impoverished neighborhoods that suffer from inadequate housing. Such cities are the result of individual or communal initiatives that must self-construct their neighborhoods. Most of the self-constructed cities are located near endangered bioregions on the Earth…
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Obtaining purified human intestinal epithelia for single-cell analysis and organoid culture
Summary: Here, we describe protocols for the preparation and dissociation of human fetal and pediatric intestinal tissue to a high-viability epithelial single-cell suspension. This epithelium-enriched single-cell suspension can then be used to generate single-cell RNA sequencing data as well as to…
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A functional genetic toolbox for human tissue-derived organoids
Human organoid systems recapitulate key features of organs offering platforms for modelling developmental biology and disease. Tissue-derived organoids have been widely used to study the impact of extrinsic niche factors on stem cells. However, they are rarely used to study endogenous gene function…
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Breast Volume Is a Predictor of Higher Heart Dose in Whole-Breast Supine Free-Breathing Volumetric-Modulated Arc Therapy Planning
In breast cancer volumetric-modulated arc therapy (VMAT) planning, the rotation of the gantry around the target implies a greater dose spreading to the whole heart, compared to tangential-field standard treatment. A consecutive cohort of 121 breast cancer patients treated with the VMAT technique…
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An unusual case of spleen metastasis from carcinoma ex pleomorphic adenoma of the parotid gland
Carcinoma ex pleomorphic adenoma is a rare tumor arising from the salivary glands that spreads through direct extension, through the lymphatic vessels, and, rarely, hematogenously. When distant metastases have been found, they have been reported mainly in the lung. We present an unusual case of…
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Strategies for Delivery of siRNAs to Ovarian Cancer Cells
The unmet need for novel therapeutic options for ovarian cancer (OC) deserves further investigation. Among the different novel drugs, small interfering RNAs (siRNAs) are particularly attractive because of their specificity of action and efficacy, as documented in many experimental setups. However…
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Haploinsufficient phenotypes promote selection of PTEN and ARID1A-deficient clones in human colon
Abstract Cancer driver mutations are defined by their high prevalence in cancers and presumed rarity in normal tissues. However, recent studies show that positive selection in normal epithelia can increase the prevalence of some cancer drivers. To determine their true cancer-driving potential, it…
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Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness
Despite the advances in anticancer therapies, their effectiveness for many human tumors is still far from being optimal. Significant improvements in treatment efficacy can come from the enhancement of drug specificity. This goal may be achieved by combining the use of therapeutic molecules with…
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A predictive model of polymetastatic disease from a multicenter large retrospectIve database on colorectal lung metastases treated with stereotactic ablative radiotherapy: The RED LaIT-SABR study
Aim: Stereotactic ablative radiotherapy (SABR) showed increasing survival in oligometastatic patients. Few studies actually depicted oligometastatic disease (OMD) evolution and which patient will remain disease-free and which will rapidly develop a polymetastatic disease (PMD) after SABR…