40 results for "Guobin Fu"
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Journal Article
PLK1 in cancer therapy: a comprehensive review of immunomodulatory mechanisms and therapeutic opportunities
PLK1 plays a crucial role in cell cycle regulation and cancer development, and its dysregulation has been implicated in the prognosis of a variety of malignancies. The potential of PLK1 inhibitors as cancer therapeutics has been extensively investigated. However, the underlying biology and…
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Clinical applications of radiomics in non-small cell lung cancer patients with immune checkpoint inhibitor-related pneumonitis
Immune checkpoint inhibitors (ICIs) modulate the body’s immune function to treat tumors but may also induce pneumonitis. Immune checkpoint inhibitor-related pneumonitis (ICIP) is a serious immune-related adverse event (irAE). Immunotherapy is currently approved as a first-line treatment for…
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Journal Article
Resilience, stress and sustainability of alluvial aquifers in the Murray-Darling Basin, Australia: Opportunities for groundwater management
Study region: Main alluvial aquifers of the Murray-Darling Basin (MDB), Australia Study focus: Around 75% of total metered groundwater use within Australia’s Murray-Darling Basin (MDB), arguably the nation’s most important food and fibre production region, is extracted from eight main alluvial…
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Understanding the Spatial Variability of the Relationship between InSAR-Derived Deformation and Groundwater Level Using Machine Learning
The interferometric synthetic aperture radar (InSAR) technique was used in this study to derive the temporal and spatial information of ground deformation and explore its temporal correlation with groundwater dynamics. The random forest (RF) machine learning method was used to model the spatial…
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Spatial and Temporal Variability of Terrestrial Water Storage and Their Relationship with Groundwater Level with GRACE, GLDAS and Observations: A Case Study of Murray–Darling Basin
Spatial and temporal patterns of terrestrial water storage (TWS), and their relationship with groundwater levels, were investigated with the Gravity Recovery and Climate Experiment (GRACE) satellite data, the Global Land Data Assimilation System (GLDAS) land surface model results, and climate…
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Journal Article
Explainable AI for Interpreting Spatiotemporal Groundwater Predictions
Abstract As machine learning models become more widely relied on for groundwater predictions, the ability to interpret and explain these predictions is increasingly important. Explainable AI (XAI) tools are addressing this challenge by enhancing model transparency. Importantly, XAI also offers an…
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Journal Article
A multi-variable calibration framework at the grid scale for integrating streamflow with evapotranspiration data to improve the simulation of distributed hydrological model
Study region: The Ganjiang River Basin, China Study focus: Parameter calibration is crucial for the accurate and reliable operation of hydrological models. Traditional methods face challenges in calibrating spatially heterogeneous parameters of distributed hydrological models, and existing…
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Long-Term Trends and Variability of Hydroclimate Variables and Their Linkages with Climate Indices in the Songhua River
The long-term trends and variability of hydroclimate variables are critical for water resource management, as well as adaptation to climate change. Three popular methods were used in this study to explore the trends and variability of hydroclimate variables during last 122 years in the Songhua…
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Journal Article
Opportunities and challenges of immune checkpoint inhibitors for extensive‐stage small‐cell lung cancer
Abstract Small‐cell lung cancer (SCLC) accounts for 15%–20% of primary lung cancers, and it is characterized by low differentiation, rapid proliferation, and early metastasis. At least two‐thirds of SCLC patients present with the extensive stage (ES) at the time of initial clinical diagnosis. Over…
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Can GCMs Simulate ENSO Cycles, Amplitudes, and Its Teleconnection Patterns with Global Precipitation?
The ability of a general circulation model (GCM) to capture the variability of El Niño–Southern Oscillation (ENSO) is not only a scientific issue of climate model performance, but also critical for climate change and variability impact studies. Here, we assess 48 CMIP5 GCMs for their skill in…
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Journal Article
Isotopic evidence for soil water sources and reciprocal movement in a semi-arid degraded wetland: Implications for wetland restoration
Understanding water dynamics is a prerequisite for the restoration of degraded ecosystems in arid and semiarid regions. In this study, we carried out δD and δ18O analyses of precipitation, unsaturated soil water, overland flow, surface runoff, and groundwater samples from a seasonally flooded…
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Journal Article
Frequency Security Constrained Optimal Operation of Low-Inertia Power Systems: Review and Prospects
With the rapid increase in penetration rate of power electronic interface resources, the level of power system inertia is significantly reduced, and the frequency dynamic characteristics of the power system dominated by the traditional synchronous machine undergoes a profound change. In this paper…
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Journal Article
Quantitative analysis of nonlinear climate change impact on drought based on the standardized precipitation and evapotranspiration index
Exploring the impact of climate change on drought under changing environmental conditions is crucial for agriculture, ecology, and human society. To evaluate the role of climate change on drought, this study selected the Songnen Plain (SNP) in Northeast China as a study area in which to quantify…
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Source–Load Coordinated Multi-Stage Low-Carbon Planning for Data Center Clusters Considering Construction Sequence
Planning data center clusters requires explicit consideration of construction sequencing and load growth over the planning horizon to avoid redundant early-stage capacity and premature investment while preventing capacity shortages and deterioration in power-supply reliability during later stages…
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Optimal Operation Strategy Considering Shared Hydrogen Energy Storage and Data Center Load Scheduling
Data centers are facing rapidly increasing electricity demand and carbon emissions, while the intermittency of renewable energy creates a significant temporal mismatch between renewable generation and data center load demand. To bridge this temporal mismatch, we propose a coordinated optimization…
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Journal Article
Attribution and spatial heterogeneity of groundwater level drivers: Gnangara region in Western Australia
Study Region: The Gnangara region in Western Australia, characterized by a Mediterranean climate with rainfall-dominated recharge, supplies approximately 60% of Perth’s drinking water.Study Focus: This study established spatiotemporal models between GLD and 87 climate and non-climate variables…
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An Integrated Framework for Wetland Degradation Risk Assessment
Wetland area and quality have continued to decline worldwide due to the combined impacts of global climate change and human activities, so there is a need for a scientific and standardized framework to assess wetland degradation risk and support conservation and restoration efforts. In this study…
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Effects of Temperature on Structural Properties of Hydrated Montmorillonite: Experimental Study and Molecular Dynamics Simulation
Montmorillonite (MMT) is highly sensitive to environmental changes and therefore plays a key role in the structural evolution of rocks and soils and even damage and disasters. The effects of important environmental factors (the temperature and water content) on MMT structural properties require…
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Temporal and Spatial Variations of Drought in China: Reconstructed from Historical Memorials Archives during 1689-1911
In China, Zou Zhe (Memorials to the Throne, or Palace Memorials), an official communication to the emperors of China by local officials, offers an opportunity to reconstruct the spatial-temporal distributions of droughts at a high-resolution. A 223-year, 1689–1911, time series of drought events was…
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Trend and change points of streamflow in the Yellow River and their attributions
The impacts of climate change and human activity, combined with streamflow reduction in the Yellow River Basin, have presented significant challenges to water resource management strategies. Here, the trends and change points of streamflow were determined for the period 1956–2017 via five…