58 hasil untuk "Hein Putter"
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Artikel Jurnal
Special Issue about Competing Risks and Multi-State Models
There is a clear growing interest, at least in the statistical literature, in competing risks and multi-state models. With the rising interest in competing risks and multi-state models a number of software packages have been developed for the analysis of such models. The present special issue of…
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Artikel Jurnal
A note on computing average state occupation times
Objective: This review discusses how biometricians would probably compute or estimate expected waiting times, if they had the data. Methods: Our framework is a time-inhomogeneous Markov multistate model, where all transition hazards are allowed to be time-varying. We assume that the cumulative…
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Artikel Jurnal
Software for multistate analysis
Background: The growing interest in pathways, the increased availability of life-history data,innovations in statistical and demographic techniques, and advances in softwaretechnology have stimulated the development of software packages for multistatemodeling of life histories. Objective: In the…
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Artikel Jurnal
frailtyEM: An R Package for Estimating Semiparametric Shared Frailty Models
When analyzing correlated time to event data, shared frailty (random effect) models are particularly attractive. However, the estimation of such models has proved challenging. In semiparametric models, this is further complicated by the presence of the nonparametric baseline hazard. Although recent…
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Artikel Jurnal Teks lengkap
A tutorial on frailty models
The hazard function plays a central role in survival analysis. In a homogeneous population, the distribution of the time to event, described by the hazard, is the same for each individual. Heterogeneity in the distributions can be accounted for by including covariates in a model for the hazard, for…
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Artikel Jurnal
mstate: An R Package for the Analysis of Competing Risks and Multi-State Models
Multi-state models are a very useful tool to answer a wide range of questions in survival analysis that cannot, or only in a more complicated way, be answered by classical models. They are suitable for both biomedical and other applications in which time-to-event variables are analyzed. However…
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Artikel Jurnal
Statistical models versus machine learning for competing risks: development and validation of prognostic models
Abstract Background In health research, several chronic diseases are susceptible to competing risks (CRs). Initially, statistical models (SM) were developed to estimate the cumulative incidence of an event in the presence of CRs. As recently there is a growing interest in applying machine learning…
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Artikel Jurnal
Graphical calibration curves and the integrated calibration index (ICI) for competing risk models
Abstract Background Assessing calibration—the agreement between estimated risk and observed proportions—is an important component of deriving and validating clinical prediction models. Methods for assessing the calibration of prognostic models for use with competing risk data have received little…
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Artikel Jurnal
Survival prediction models since liver transplantation - comparisons between Cox models and machine learning techniques
Abstract Background Predicting survival of recipients after liver transplantation is regarded as one of the most important challenges in contemporary medicine. Hence, improving on current prediction models is of great interest.Nowadays, there is a strong discussion in the medical field about…
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Artikel Jurnal
Clarifying the biological and statistical assumptions of cross-sectional biological age predictors: an elaborate illustration using synthetic and real data
Abstract Background There is divergence in the rate at which people age. The concept of biological age is postulated to capture this variability, and hence to better represent an individual’s true global physiological state than chronological age. Biological age predictors are often generated based…
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Artikel Jurnal
Modeling Long-Term Erythropoietic Recovery After Allogeneic Stem Cell Transplants in Pediatric Patients
Long term erythropoietic reconstitution after allogeneic hematopoietic stem cell transplantation (alloHSCT) has not been extensively studied. We aimed to describe erythropoietic reconstitution as an indicator of long-term graft function by modeling hemoglobin levels during the first 3 years post…
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Artikel Jurnal Teks lengkap
Prenatal Famine and Genetic Variation Are Independently and Additively Associated with DNA Methylation at Regulatory Loci within IGF2 / H19
Both the early environment and genetic variation may affect DNA methylation, which is one of the major molecular marks of the epigenome. The combined effect of these factors on a well-defined locus has not been studied to date. We evaluated the association of periconceptional exposure to the Dutch…
Juga tersedia di: DOAJ
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Artikel Jurnal
The prognostic value of the tumor-stroma ratio in squamous cell lung cancer, a cohort study
Objectives: The tumor-stroma ratio (TSR) is based on the relative amount of stroma in the primary tumor and has proven to be an independent prognostic factor in various solid tumors. The prognosis of patients and adjuvant treatment decision making in lung squamous cell carcinomas (SqCC) is based on…
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Artikel Jurnal
A new framework for disentangling different components of excess mortality applied to Dutch care home residents during Covid-19
Abstract Background Vulnerable subgroups of the population, such as care home residents, often face elevated mortality risks during crises like pandemics or wars. To correctly model and interpret the excess mortality of vulnerable groups during crises, a distinction must be made between the…
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Artikel Jurnal
Survival benefit from liver transplantation for patients with and without hepatocellular carcinoma
Background & Aims: In the USA, inequal liver transplantation (LT) access exists between patients with and without hepatocellular carcinoma (HCC). Survival benefit considers survival without and with LT and could equalise LT access. We calculated bias-corrected LT survival benefit for patients…
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Artikel Jurnal Teks lengkap
Combined Assessment of the Tumor–Stroma Ratio and Tumor Immune Cell Infiltrate for Immune Checkpoint Inhibitor Therapy Response Prediction in Colon Cancer
The best current biomarker strategies for predicting response to immune checkpoint inhibitor (ICI) therapy fail to account for interpatient variability in response rates. The histologic tumor–stroma ratio (TSR) quantifies intratumoral stromal content and was recently found to be predictive of…
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Artikel Jurnal
Evaluating discrimination of prediction models for recurrent clinical events
Abstract Background Prediction models for clinical conditions involving recurrent events require performance metrics tailored to repeated outcomes. Although we and others have developed methods to evaluate calibration and related aspects of performance, approaches for assessing discrimination…
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Artikel Jurnal
Development and validation of a dynamic survival prediction model for patients with acute-on-chronic liver failure
Background & Aims: Acute-on-chronic liver failure (ACLF) is usually associated with a precipitating event and results in the failure of other organ systems and high short-term mortality. Current prediction models fail to adequately estimate prognosis and need for liver transplantation (LT) in ACLF…
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Artikel Jurnal
A comparison of modeling approaches for static and dynamic prediction of central-line bloodstream infections using electronic health records (part 1): regression models
Abstract Background Hospitals register information in the electronic health records (EHRs) continuously until discharge or death. As such, there is no censoring for in-hospital outcomes. We aimed to compare different static and dynamic regression modeling approaches to predict central…